Reduction of Pain Thresholds in Fibromyalgia after Very Low-Intensity Magnetic Stimulation: A Double-Blinded, Randomized Placebo-Controlled Clinical Trial

Maestú, Ceferino; Blanco, Manuel de Gracia; Nevado, Ángel; Romero, J. Merino; Rodríguez-Rubio, Patricia; J, Galindo; Lorite, Juan Bautista; Morenas, Francisco de las; Fernández-Argüelles, Pedro

doi:10.1155/2013/270183

Cited by 37 publications

(30 citation statements)

References 33 publications

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“…Future studies should compare our ELF-MF protocol (which had benefits without any side effects) with other more intensive programs, for example, daily treatment or doubling the number of sessions in a single day. Existing TMS protocols for the treatment of pain in FM differ in frequency (nearly always pulsed), intensity, duration, and setting [28][29][30][31]; no standardized protocol for ELF-MF treatment in FM has been developed, and there are no studies in this area with respect to total body stimulation with the magnetic mattress. Consistent with similar studies, our results demonstrate an analgesic and antinociceptive effect, similar to the opioid analgesic effect in PEMFexposed patients [39][40].…”

Section: Discussionmentioning

confidence: 99%

“…No study has examined the efficacy of ELF-MFs in FM, excluding reports on transcranial pulsed MFs [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, Maestú and colleagues studied the effect of very low-intensity pulsed transcranial magnetic stimulation (TMS) on FM (once per week, 8 sessions, 20 min duration, 43 nT for each coil, 8 Hz) and noted that it had analgesic and antinociceptive effects, similar to the opioid analgesic effects in PEMFexposed patients [29]. Nevertheless, there is no definitive treatment modality that is effective in FM patients, and the results are often mixed.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

et al. 2016

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Abstract-The purpose of this pilot study was to determine the efficacy of an extremely low-frequency magnetic field (ELF-MF) in decreasing chronic pain in fibromyalgia (FM) patients. Thirty-seven females were recruited and randomized into two groups: one group was first exposed to systemic ELF-MF therapy (100 microtesla, 1 to 80 Hz) and then to sham therapy, and the other group received the opposite sequence of intervention. Pain, FM-related symptoms, and the ability to perform daily tasks were measured using the Visual Analog Scale, Fibromyalgia Impact Questionnaire (FIQ), Fibromyalgia Assessment Scale (FAS), and Health Assessment Questionnaire (HAQ) at baseline, end of first treatment cycle, beginning of second treatment cycle (after 1 mo washout), end of second treatment cycle, and end of 1 mo follow-up. ELF-MF treatment significantly reduced pain, which increased on cessation of therapy but remained significantly lower than baseline levels. Short-term benefits were also observed in FIQ, FAS, and HAQ scores, with less significant effects seen in the medium term. ELF-MF therapy can be recommended as part of a multimodal approach for mitigating pain in FM subjects and improving the efficacy of drug therapy or physiotherapy.Clinical Trial Registration: ClinicalTrials.gov; "Very low frequency magnetic fields in the treatment of fibromyalgia": NCT02231541;https://clinicaltrials.gov/ct2/show/ NCT02231541?term=NCT02231541&rank=1

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Section: Discussionmentioning

confidence: 99%

“…No study has examined the efficacy of ELF-MFs in FM, excluding reports on transcranial pulsed MFs [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

et al. 2016

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“…Improvements in pain intensity were paralleled to improvements in secondary outcomes. Very low-intensity magnetic stimulation may represent a safe and effective treatment for chronic pain and other symptoms associated with conditions without structural damages but with dysfunctional disorders like fibromyalgia 25,26 . ELF-PEMF can also influence modification of pain in polyneuropathy which is common in the ESRD patients on dialysis 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Effects of extremely low frequency pulsed electromagnetic field added to kinesitherapy procedure on quality of life in patients with end stage renal disease on dialysis

et al. 2018

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Background/Aim. Extremely Low Frequency Pulsed Electromagnetic Magnetic Field (ELF-PEMF) has a wide range of therapeutic applications which were expanding during the last decades. ELF-PEMF, as non-invasive, longterm safe method of physical therapy can influence a variety of aspects in chronic diseases including quality of life. Patients with chronic kidney disease (CKD), especially with end stage renal disease (ESRD), treated by dialysis, have lower health-related quality of life and changed normal way of living because of ESRD-related comorbid illnesses, associated conditions and complex dialysis procedures. The objective of this study was to assess the effectiveness of longterm ELF-PEMF in concordance with exercising on quality of life in ESRD patients on dialysis. Methods. A total of 124 patients (59 men and 65 women) with ESRD on dialysis program were divided into study group and control group. Patients included in the study group (n = 54) agreed to receive treatment with ELF-PEMF (18 Hz, 2 mT, applied during 40 minutes after ten consecutive dialysis procedures, four times through one year, 120 treatments in total) together with kinesitherapy over three years. The patients in the control group (n = 70) were subjected only to kinesitherapy as a physical therapy procedure. Quality of life was assessed through the Short Form Health Survey, version 2 (SF36v2) and the Functional Assessment of Chronic Illness Therapy, version 4 (FACIT Fatigue v4) questionnaires. Results. In the study group, treatment with ELF-PEMF significantly improved FACIT Fatigue v4 scale score as well as physical health, physical functioning, bodily pain and energy/fatigue domains of SF=36v2 scale. There were no effects on mental health domain, limitations due to physical health problems, limitations due to personal or emotional problems, emotional well-being, social functioning, and general health perceptions. In the control group, no beneficial effects on FACIT Fatigue v4 scale and SF36v2 scale item were noticed. Conclusion. ELF-PEMF could be a additional and safe strategy for improving quality of life in patients with ESRD on dialysis.

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“…Low-intensity rTMS may also be an effective treatment option for patients with FMS for improving the pain threshold [6].…”

Section: Discussionmentioning

confidence: 99%

Implantable drug delivery systems with morphine in fibromyalgia -A case report-

Shin

Choi

et al. 2017

Anesth Pain Med

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.The fibromyalgia syndrome (FMS) could be approached by various treatments modalities including education, aerobic exercise, cognitive behavioral therapy, tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors, pregabalin, and so on. If other treatments fail, opioids including morphine should be considered. In this case report, we describe the case of a 44-year-old woman who was diagnosed with FMS three years ago, and suffered from severe intractable pain, side effects from other drugs, and opioid tolerance. Administration of morphine via an implantable drug delivery system resulted in significant improvement in the patient's pain intensity, fibromyalgia impact questionnaire score, and sleep disturbance. Our case demonstrates that an implantable drug delivery system with morphine can be a potential treatment option for refractory fibromyalgia patients.

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Reduction of Pain Thresholds in Fibromyalgia after Very Low-Intensity Magnetic Stimulation: A Double-Blinded, Randomized Placebo-Controlled Clinical Trial

Abstract: Very low-intensity magnetic stimulation may represent a safe and effective treatment for chronic pain and other symptoms associated with fibromyalgia.

Cited by 37 publications

References 33 publications

Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

Efficacy of extremely low-frequency magnetic field in fibromyalgia pain: A pilot study

Effects of extremely low frequency pulsed electromagnetic field added to kinesitherapy procedure on quality of life in patients with end stage renal disease on dialysis

Implantable drug delivery systems with morphine in fibromyalgia -A case report-

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