Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration

Campieri, Claudio; Campieri, Massimo; Bertuzzi, Veronica; Swennen, Erwin; Matteuzzi, Diego; Stefoni, Sergio; Pirovano, F.; Centi, Carla; Ulisse, Salvatore; Famularo, Giuseppe; Simone, Claudio De

doi:10.1046/j.1523-1755.2001.0600031097.x

Cited by 212 publications

(169 citation statements)

References 25 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…It is interesting that their transcription occurred only when first adapted to subinhibitory concentrations of oxalate and then exposed to pH 5.5 (11). These requirements for gene transcrip- tion may explain the failure to detect previously the genes in Oxadrop strains (3). These specific and necessary conditions may also represent obstacles in the use of these bacteria as therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

“…Because the preparation has not yet been made commercially available, only two batches have been made. Although produced by the same manufacturer, the preparation that we used differed from that used in an earlier study in that the current product did not contain a strain of Lactobacillus plantarum, which had no significant ability to degrade oxalate (3). As further quality control, each batch is assayed and confirmed to be negative for contamination with other species such as enterococcal species, Listeria, coliforms, Escherichia coli, Salmonella species, and Staphylococcus aureus.…”

Section: Study Preparationmentioning

confidence: 99%

See 1 more Smart Citation

A Randomized, Controlled Trial of Lactic Acid Bacteria for Idiopathic Hyperoxaluria

Goldfarb

Modersitzki²,

Asplin³

2007

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background: Urinary oxalate excretion is an important contributor to calcium oxalate stone formation. Methods of reducing oxalate excretion are not wholly satisfactory, and no controlled trials using them have been performed to prevent stone recurrence. Some lactic acid bacteria can degrade oxalate in vitro. This study sought to reduce urinary oxalate excretion in calcium stone formers with idiopathic hyperoxaluria.Design, setting, participants, and measurements: A randomized, double-blind, placebo-controlled trial was performed of Oxadrop, a mix of four lactic acid bacterium species. This preparation previously reduced oxalate excretion in stone formers with idiopathic and enteric hyperoxaluria. Patients were selected from two stone prevention clinics. Twenty people with calcium stones and idiopathic hyperoxaluria (>40 mg/d) were enrolled and randomly assigned 1:1 in placebo and active preparation arms. Both groups took 3.6 g of granulate each day: Either placebo or the experimental preparation. Participants performed two consecutive 24-h urine collections at baseline, at 28 d of therapy, and at 56 d, after being off the preparation for 4 wk. Diet was replicated at each point.Results: There was no effect of the study preparation: Mean 24-h urinary oxalate excretion in placebo-treated patients was 73.9 mg at baseline and 72.7 mg after treatment, whereas the Oxadrop-treated patients had 59.1 mg at baseline and 55.4 mg after treatment. The preparation was well tolerated; three participants on active treatment experienced mild constipation.Conclusions: In this randomized, placebo-controlled trial, Oxadrop did not reduce urinary oxalate excretion in participants with idiopathic hyperoxaluria.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Study Preparationmentioning

confidence: 99%

A Randomized, Controlled Trial of Lactic Acid Bacteria for Idiopathic Hyperoxaluria

Goldfarb

Modersitzki²,

Asplin³

2007

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…The role of O. formigenes for scavenging dietary oxalate has been confirmed by studies of the urinary oxalate excretion in both rats fed oxalate and hyperoxaluric rats administered O. formigenes (45,46). Furthermore, Campieri et al (9) reported that variation of the intestinal microbiota composition, due to the oral administration of the probiotic bacteria Bifidobacterium and Lactobacillus, reduced the urinary oxalate excretion in patients with idiopathic calcium-oxalate urolithiasis and mild hyperoxaluria.…”

mentioning

confidence: 93%

Characterization and Heterologous Expression of the Oxalyl Coenzyme A Decarboxylase Gene from Bifidobacterium lactis

Federici

Vitali

Gotti

et al. 2004

Appl Environ Microbiol

View full text Add to dashboard Cite

“…First, because one patient developed AON within 8 weeks after stopping enzyme supplementation, whether insufficient enzyme therapy was a trigger of AON in the remaining patients is open to question. Second, the role of intestinal colonization by Oxalobacter formigenes (OF) in oxalate gut absorption has been emphasized (33). OF degrades intraluminal soluble oxalate and decreases the colonic oxalate absorption (34).…”

Section: Discussionmentioning

confidence: 99%

Oxalate Nephropathy Associated with Chronic Pancreatitis

Cartery¹,

Faguer²,

Karras³

et al. 2011

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

SummaryBackground and objectives Enteric overabsorption of oxalate may lead to hyperoxaluria and subsequent acute oxalate nephritis (AON). AON related to chronic pancreatitis is a rare and poorly described condition precluding early recognition and treatment.Design, setting, participants, & measurements We collected the clinical characteristics, treatment, and renal outcome of 12 patients with chronic pancreatitis-associated AON followed in four French renal units.Results Before AON, mild to moderate chronic kidney disease was present in all patients, diabetes mellitus in eight (insulin [n ϭ 6]; oral antidiabetic drugs [n ϭ 2]), and known chronic pancreatitis in only eight. At presentation, pancreas imaging showed gland atrophy/heterogeneity, Wirsung duct dilation, calcification, or pseudocyst. Renal findings consisted of rapidly progressive renal failure with tubulointerstitial profile. Acute modification of glomerular filtration preceded the AON (i.e., diarrhea and diuretics). Increase in urinary oxalate excretion was found in all tested patients and hypocalcemia in nine (Ͻ1.5 mmol/L in four patients). Renal biopsy showed diffuse crystal deposits, highly suggestive of oxalate crystals, with tubular necrosis and interstitial inflammatory cell infiltrates. Treatment consisted of pancreatic enzyme supplementation, oral calcium intake, and an oxalate-free diet in all patients and renal replacement therapy in five patients. After a median follow-up of 7 months, three of 12 patients reached end-stage renal disease.Conclusion AON is an under-recognized severe crystal-induced renal disease with features of tubulointerstitial nephritis that may occur in patients with a long history of chronic pancreatitis or reveal the pancreatic disease. Extrinsic triggering factors should be prevented.

show abstract

Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration

Cited by 212 publications

References 25 publications

A Randomized, Controlled Trial of Lactic Acid Bacteria for Idiopathic Hyperoxaluria

A Randomized, Controlled Trial of Lactic Acid Bacteria for Idiopathic Hyperoxaluria

Characterization and Heterologous Expression of the Oxalyl Coenzyme A Decarboxylase Gene from Bifidobacterium lactis

Oxalate Nephropathy Associated with Chronic Pancreatitis

Contact Info

Product

Resources

About