“…In myocardial ischemia and reperfusion injury, the Na + /H + exchanger has been shown to be involved in arrhythmia, stunning and necrosis in several models, using inhibitors of the Na + /H + exchanger such as ethylisopropyl-amiloride [1], HOE694 [3,6], HOE642 [2,5], EMD85131 [4], and SM-20550 [7,8,10]. Many studies have revealed the effectiveness of inhibitors of the Na + / H + exchanger in attenuating myocardial ischemia and reperfusion injury in rabbit, porcine and canine models with short reperfusion period; however, the present study is the first demonstration of the effect of as inhibitor of Na + /H + exchanger, SM-20550, on survival rate after a long-term reperfusion period in any species.…”