Reduction of ketones to corresponding alcohols with magnesium metal in absolute alcohols

Kim, Ji Young; Kim, Hak Do; Seo, Min; Kim, Hyoung Rae; No, Zaesung; Ha, Deok Chan; Lee, Ge Hyeong

doi:10.1016/j.tetlet.2005.10.140

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Ir (Kbr) CM1

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Cited by 10 publications

(1 citation statement)

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“…Transformation of 2a: (1R,2R)-2-Benzylcyclopentan-1-ol (3). 17 A hydrogenation tube was charged with a stirring bar, 2a (0.6 mmol, 104.5 mg) and Pd/C (10 mol %), followed by the addition of THF (5 mL) using a syringe. The hydrogenation tube was then put into an autoclave.…”

Section: Ir (Kbr) CMmentioning

confidence: 99%

RuPHOX-Ru-Catalyzed Selective Asymmetric Hydrogenation of Exocyclic α,β-Unsaturated Pentanones

Zhu

et al. 2019

Organometallics

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A RuPHOX-Ru catalyzed selective asymmetric hydrogenation of exocyclic α,β-unsaturated ketones has been developed, furnishing the corresponding chiral exocyclic allylic alcohols in high yields and with up to >99.5% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 10000 S/C) without any loss in reaction activity and enantioselectivity. The resulting hydrogenated products could be easily transformed to several biologically active compounds with high asymmetric performance. The asymmetric protocol provides an efficient methodology for the synthesis of chiral exocyclic allylic alcohols.

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Section: Ir (Kbr) CMmentioning

confidence: 99%