Reduction of Intensive Care Unit Length of Stay

Hunter, Alex; Johnson, Lindsay; Coustasse, Alberto

doi:10.1097/hcm.0000000000000006

Cited by 89 publications

(46 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mechanical ventilation is one of the most common interventions implemented in intensive care units (ICU) or critical care units. The length of stay in ICU varies between 24 hr to 132 days (Arabi, Venkatesh, Haddad, Al Shimemeri, & Al Malik, ), with an average length of stay of about 3.3 days (Hunter, Johnson, & Coustasse, ). The average daily cost of stay in ICU represents one third of total health care cost, and is steadily increasing (Shorr, ).…”

Section: Discussionmentioning

confidence: 99%

Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes

Vysotskaya

Chidipi²,

Rodgers

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

Supplementation of 100% oxygen is a very common intervention in intensive care units (ICU) and critical care centers for patients with dysfunctional lung and lung disorders. Although there is advantage in delivering sufficient levels of oxygen, hyperoxia is reported to be directly associated with increasing in-hospital deaths. Our previous studies reported ventricular and electrical remodeling in hyperoxia treated mouse hearts, and in this article, for the first time, we are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting. Our data showed that induction of hyperoxia for 3 days in mice showed larger outward potassium currents with shorter action potential durations (APD). This increase in current densities is due to significant increase in ultrarapid delayed rectifier outward K currents (I ) and rapidly activating, rapidly inactivating transient outward K+ current (I ) densities. We also observed a significant increase in both transcripts and protein levels of Kv1.5 and KChIP2 in hyperoxia treated atrial cardiomyocytes, whereas no significant change was observed in Kv4.2 transcripts or protein. The data presented here further support our previous findings that hyperoxia induces not only ventricular remodeling, but also atrial electrical remodeling.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes

Vysotskaya

Chidipi²,

Rodgers

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Due to the disabilities of patients, the most important issue for ICH patients is care after the disease has been stabilized. Research has shown that early mobilization will decrease the LOS in ICU [49]. Proactive palliative care consultations for high-risk patients, for example, ICH patients, will significantly decrease the LOS in ICU [50].…”

Section: Discussionmentioning

confidence: 99%

The Definition of a Prolonged Intensive Care Unit Stay for Spontaneous Intracerebral Hemorrhage Patients: An Application with National Health Insurance Research Database

Chan

Ting

Huang

2014

BioMed Research International

View full text Add to dashboard Cite

Introduction. Length of stay (LOS) in the intensive care unit (ICU) of spontaneous intracerebral hemorrhage (sICH) patients is one of the most important issues. The disease severity, psychosocial factors, and institutional factors will influence the length of ICU stay. This study is used in the Taiwan National Health Insurance Research Database (NHIRD) to define the threshold of a prolonged ICU stay in sICH patients. Methods. This research collected the demographic data of sICH patients in the NHIRD from 2005 to 2009. The threshold of prolonged ICU stay was calculated using change point analysis. Results. There were 1599 sICH patients included. A prolonged ICU stay was defined as being equal to or longer than 10 days. There were 436 prolonged ICU stay cases and 1163 nonprolonged cases. Conclusion. This study showed that the threshold of a prolonged ICU stay is a good indicator of hospital utilization in ICH patients. Different hospitals have their own different care strategies that can be identified with a prolonged ICU stay. This indicator can be improved using quality control methods such as complications prevention and efficiency of ICU bed management. Patients' stay in ICUs and in hospitals will be shorter if integrated care systems are established.

show abstract

“…Our study suggests that the implementation of an intensive PT program may not be indicated for all critically ill patients who require mechanical ventilation for at least 4 days. Much of the rationale for providing intensive PT has been based on shortening ICU and hospital lengths of stay, and therefore on reducing hospital costs (53). Though PT is a relatively safe intervention, it is labor intensive (54).…”

Section: Discussionmentioning

confidence: 99%

A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure

Moss

Nordon‐Craft

Malone

et al. 2016

Am J Respir Crit Care Med

276

212

View full text Add to dashboard Cite

Rationale: Early physical therapy (PT) interventions may benefit patients with acute respiratory failure by preventing or attenuating neuromuscular weakness. However, the optimal dosage of these interventions is currently unknown.Objectives: To determine whether an intensive PT program significantly improves long-term physical functional performance compared with a standard-of-care PT program.Methods: Patients who required mechanical ventilation for at least 4 days were eligible. Enrolled patients were randomized to receive PT for up to 4 weeks delivered in an intensive or standard-of-care manner. Physical functional performance was assessed at 1, 3, and 6 months in survivors who were not currently in an acute or long-term care facility. The primary outcome was the Continuous Scale Physical Functional Performance Test short form (CS-PFP-10) score at 1 month. Measurements and Main Results:A total of 120 patients were enrolled from five hospitals. Patients in the intensive PT group received 12.4 6 6.5 sessions for a total of 408 6 261 minutes compared with only 6.1 6 3.8 sessions for 86 6 63 minutes in the standard-of-care group (P , 0.001 for both analyses). Physical function assessments were available for 86% of patients at 1 month, for 76% at 3 months, and for 60% at 6 months. In both groups, physical function was reduced yet significantly improved over time between 1, 3, and 6 months. When we compared the two interventions, we found no differences in the total CS-PFP-10 scores at all three time points (P = 0.73, 0.29, and 0.43, respectively) or in the total CS-PFP-10 score trajectory (P = 0.71).Conclusions: An intensive PT program did not improve long-term physical functional performance compared with a standard-of-care program.Clinical trial registered with www.clinicaltrials.gov (NCT01058421).

show abstract

Reduction of Intensive Care Unit Length of Stay

Cited by 89 publications

References 26 publications

Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes

Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes

The Definition of a Prolonged Intensive Care Unit Stay for Spontaneous Intracerebral Hemorrhage Patients: An Application with National Health Insurance Research Database

A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure

Contact Info

Product

Resources

About