Reduction of hospitalizations with diarrhea among children aged 0–5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine

Ahmed, Mohamed-Lemine Cheikh-brahim; Heukelbach, Jörg; Weddih, Abdellahi; Filali-Maltouf, Abdelkarim; Sidatt, Mariem; Makhalla, Khattry; Dahdi, Sid'Ahmed; Ahmed, Aly Cheybany Cheikh; El-Mami, Mohamed Val; Tate, Jacqueline E.; Parashar, Umesh D.; Benhafid, Mohammed

doi:10.1016/j.vaccine.2019.01.078

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…The proportion of childhood hospitalizations with diarrhea in Nouakchott city (in Mauritania) declined by nearly 25%, largely due to the increased availability of vaccines. These reductions occurred in children in the 3 months to 5 years age group, with the largest reduction occurring in 2-5-year-olds (Ahmed et al 2019). These findings support a significant role of rotavirus vaccination in the reductions in childhood diarrhea hospitalizations, which also provides an indirect benefit to older age groups by less viral exposure to their younger (vaccinated) contacts.…”

Section: The Benefits Of Rotavirus Vaccinationsupporting

confidence: 53%

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Ahmed¹,

El-Vally²

2020

Handbook of Healthcare in the Arab World

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Diarrhea is a leading cause of morbidity and mortality among children under 5 in developing countries. Two rotavirus vaccines have been licensed in more than 100 countries around the world since 2006. In the Arab Maghreb countries, rotavirus vaccines were initially introduced in Morocco in 2010 and then in Libya and Mauritania in 2013 and 2014, respectively. This chapter describes the burden of childhood diarrhea diseases and the health benefits of rotavirus vaccination in the Arab Maghreb countries, with a view to restricting the evolution of the disease and to identify features differentiating its epidemiology. Information provided in this chapter were extracted from the World Health Organization's weekly reports and information issued by the ministries of health in these countries as well as from published papers. The data shows a high rate of

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Section: The Benefits Of Rotavirus Vaccinationsupporting

confidence: 53%

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Ahmed¹,

El-Vally²

2020

Handbook of Healthcare in the Arab World

View full text Add to dashboard Cite

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Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Ahmed¹,

El-Vally²

2021

Handbook of Healthcare in the Arab World

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Oral Immunization against ETEC with Recombinant Protein-Loaded Chitosan Nano-Structure and its Immunogenicity in Comparison with Subcutaneous Vaccine

Hosseini

Amani

Hosseini

et al. 2023

CNANO

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Background: Enterotoxigenic E.coli (ETEC), can be considered as the main cause of traveler’s diarrhea which is effecting children in developing countries. The bacterium has several virulence factors, including colonization factors (CFs), heat-labile (LT) and heat-stable (ST) toxins. World Health Organization has made this one of its priorities to produce a vaccine against ETEC due to its increased antibiotic resistance and growing limitations of access to clean drinking water sources. Objective: The objective of this study is to investigate oral immunogenicity of chitosan nanoparticles (CNPs) encapsulated CCL protein containing CfaB along with STa toxoid, CfaE and LtB. Methods: The E.coli BL21DE3 harboring pET-28a-ccl vector was used for protein expression. After purification and confirmation, the protein was encapsulated in CNPs and the particle size was measured. Immunogenicity was assessed by evaluating antibody titers after BALB/c mice vaccination. Finally, neutralization efficiency of immunized mice sera was evaluated by rabbit ileal loop test. Results: The purified protein (~57kDa) was confirmed by Western blotting and the size of CCL-CNPs was measured with average of 112.0nm with 98.8% of encapsulation efficiency. CCL-CNPs are able to stimulate immune system by providing suitable titers of antibody. The fluid accumulation in the rabbit’s intestine was significantly reduced. Conclusion: the CCL-CNPs can be considered as a candidate for producing oral nanovaccine.

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Reduction of hospitalizations with diarrhea among children aged 0–5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine

Cited by 5 publications

References 12 publications

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Oral Immunization against ETEC with Recombinant Protein-Loaded Chitosan Nano-Structure and its Immunogenicity in Comparison with Subcutaneous Vaccine

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Reduction of hospitalizations with diarrhea among children aged 0–5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine

Cited by 5 publications

References 12 publications

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Childhood Diarrhea in the Maghreb Arabic Union and Health Benefits of Rotavirus Vaccination

Oral Immunization against ETEC with Recombinant Protein-Loaded Chitosan Nano-Structure and its Immunogenicity in Comparison with Subcutaneous Vaccine

Contact Info

Product

Resources

About

Reduction of hospitalizations with diarrhea among children aged 0–5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine