Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion

Rogers, William J.; Stanley, Alfred W.H.; Breinig, John B.; Prather, John W.; McDaniel, Huey G.; Moraski, Roger E.; Mantle, John A.; Russell, Richard O.; Rackley, Charles E.

doi:10.1016/s0002-8703(76)80043-9

Cited by 136 publications

(37 citation statements)

References 52 publications

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“…As therapy for patients with an AMI, GIK therapy is associated with the expected decrease in FFAs, decreased heart failure, and a suggestion of improved short-term survival (133)(134)(135)139,164). In follow-up of a first myocardial infarction (MI), individuals who received GIK therapy reported better stress tolerance, an elevated ischemic threshold, and improved myocardial perfusion by 99 m-Tctetrofosmin-gated single photon emission computed tomography (SPECT) compared with those receiving saline infusion (149).…”

Section: Is Insulin Per Se Therapeutic?mentioning

confidence: 99%

Management of Diabetes and Hyperglycemia in Hospitals

et al. 2004

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Section: Is Insulin Per Se Therapeutic?mentioning

confidence: 99%

Management of Diabetes and Hyperglycemia in Hospitals

et al. 2004

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“…139 The infusion of GIK was shown to reduce the frequency and duration of ventricular arrhythmias and to improve the survival of patients after myocardial infarction. 140,141 Similarly, beneficial effects on ejection fraction and survival were observed when GIK was administered in conjunction with a thrombolytic agent 142 or when GIK was given to patients with myocardial infarction and non-insulindependent diabetes mellitus. 143 Most recently, a meta-analysis of all placebo-controlled trials of GIK treatment in acute myocardial infarction has shown an overall mortality reduction of 28%.…”

Section: Glucose and Insulin As Substrates For Postischemic Heartmentioning

confidence: 98%

Glucose for the Heart

Depré¹,

Vanoverschelde²,

Taegtmeyer³

1999

Circulation

377

260

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“…In the 1960s SodiPallares further popularized this treatment initially for arrhythmias, and later for angina (18,19). Glucose-insulin-potassium infusions have been advocated for patients with acute myocardial infarctions by other investigators and have also been administered before cardiac surgery (20)(21)(22)(23)(24)(25)(26)(27). Animal studies have shown that glucose infusions increase ATP levels and glycogen stores, and reduce tissue necrosis during acute infarctions (28)(29)(30).…”

Section: Introductionmentioning

confidence: 99%

Effects of acute hyperglycemia on myocardial glycolytic activity in humans.

Wisneski¹,

Stanley²,

Neese³

et al. 1990

J. Clin. Invest.

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The effects of hyperglycemia on myocardial glucose metabolism were investigated in seven healthy male subjects (age 24±4 yr). I6-C4qGlucose and IU-'3Cilactate were infused as tracers. Circulating glucose was elevated to two hyperglycemic levels using a clamp technique for 1 h at each level. The mean arterial glucose concentration was 4.95±0.29 (control), 8.33±0.31 and 10.84±0.60 jumol/ml, respectively. Glucose extraction increased significantly from control (0.15±0.13 gsmol/ ml) during each level of the glucose clamp (0.28±0.12, P < 0.02, and 0.54±0.14 ;tmol/ml, P < 0.005, respectively). Myocardial production of '4CO2 showed that during control 9±10% of exogenous glucose was oxidized immediately upon extraction. Despite a significant increase in the amount of exogenous glucose oxidized with level II hyperglycemia, it represented only 32±10% of the glucose extracted.[I3C]Lactate analysis showed that the myocardium was releasing lactate; during control 40±30% of this lactate was derived from exogenous glucose and during hyperglycemia this value increased to 97±37% (P < 0.005). Thus, these data show that during short-term hyperglycemia, myocardial glucose extraction is enhanced. However, despite increases in exogenous glucose oxidation and the contribution of exogenous glucose to lactate release, the majority of the extracted glucose (i.e., 57%) is probably stored as glycogen. (J. Clin. Invest. 1990Invest. . 85:1648Invest. -1656.) myocardial metabolism * glucose oxidation * lactate release * glycogen * free fatty acids

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Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion

Cited by 136 publications

References 52 publications

Management of Diabetes and Hyperglycemia in Hospitals

Management of Diabetes and Hyperglycemia in Hospitals

Glucose for the Heart

Effects of acute hyperglycemia on myocardial glycolytic activity in humans.

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