Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids

Lee, Sang; Kim, Sendia; Le, Hau D.; Meisel, Jonathan A.; Strijbosch, Robbert; Nosé, Vânia; Puder, Mark

doi:10.1016/j.jpedsurg.2008.05.030

Cited by 29 publications

(22 citation statements)

References 26 publications

(24 reference statements)

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“…In addition, EPA reduces levels of TNF-a and IL-6 in the hepatocytes 32 ,and DHA improves hepatic injuries induced by valproate through reforming of oxidative stresses and inflammation without having any effect on plasma level of valproate 33 .Moreover, it has been shown that addition of fish oil supplement to parental diet reforms the increased levels of hepatic enzymes resulted from hepatic mal-function related to parental nutrition 34 .Studies have shown that 10% fish oil and 1 g% artichoke leaf can restore hepatocellular carcinoma in rats 35 . Lee et al (2008) determined that Omega-3 fatty acid can repair hepatocellular damage caused by obstruction of the bile ducts 36 ; it was also shown that fish oil along with allopurinol And verapamil improve hepatic injuries resulting from ischemia by a significant reduction in oxidative stress and hepatic enzymes 37 .In a study by Mardones et al (2012), it was demonstrated that combination of thyroid hormone and fish oil protocol prevents liver damage resulted from tissue injury and ischemia 38 .Furthermore, Omega-3 fatty acid prevents acute liver defects and stimulates liver regeneration following 90% hepatectomy in rats 39 . Chiang et al (2009) showed that fish oil can stimulate anti cell proliferation effect of 1-alpha 25-dihydroxy vitamin D3 on hepatic cancer cells 40 ; EPA can also improve hepatic toxicity, oxidative stress and inflammation induced by valproate 41 .…”

Section: Resultsmentioning

confidence: 99%

Protective Effects of Fish Oil Omega-3 Supplement on Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats

Moghadamnia¹,

Mokhtari²,

Khatamsaz³

2016

Biosci., Biotech. Res. Asia

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Exposure to thioacetamide causes hepatotoxicity and hepatocellular carcinoma in human, while fish oil Omega-3 supplement has anti-inflammatory effects. In this study, the protective effect of Fish oil Omega-3 supplement against liver-related biochemical factors changes induced by thioacetamide in rat is investigated.42 male rats were divided into 6 groups of seven. The control group, The sham 1 group receiving 0.4ml/kg olive oil as the solvent of Fish oil Omega-3 supplement, the sham2 group inter peritonealy receiving a dose of 150 mg/kg thioacetamide at the end of the experiment, the experimental groups 1, 2 and 3 orally receiving a daily dose of 100, 200 and 300 mg/kg Fish oil Omega-3 supplements respectively for 3 month followed by an inter peritoneal dose of 150 mg/kg thioacetamide at the end of the experiment. The serum levels of GGT, LDH, albumin and total protein were measured. Following hematoxylin-eosin staining, liver tissue samples were pathologically studied.The mean level of Albumin showed a significant reduction in experimental groups 1, 2 and 3 receiving thioacetamide. Also, the mean concentration of GGT In the experimental groups 1 and 2 compared to the group receiving thioacetamide decreased significantly; whereas, the mean levels of LDH and total protein showed no significant changes in the experimental groups 1, 2, and 3 (pd"0.05). The results of this study indicate that Fish oil Omega-3 supplement has a protective effect on liver-related biochemical factors changes induced by thioacetamide in rat.

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Section: Resultsmentioning

confidence: 99%

Protective Effects of Fish Oil Omega-3 Supplement on Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats

Moghadamnia¹,

Mokhtari²,

Khatamsaz³

2016

Biosci., Biotech. Res. Asia

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“…Studies have shown that 10% fish oil and 1 g% artichoke leaf can restore hepatocellular carcinoma in rats [36]. Lee et al determined that omega-3 fatty acid can repair hepatocellular damage caused by obstruction of the bile ducts [37]; it was also shown that fish oil along with allopurinol and verapamil improve hepatic injuries resulting from ischemia by a significant reduction in oxidative stress and hepatic enzymes [38]. In a study by Mardones et al, it was demonstrated that combination of thyroid hormone and fish oil protocol prevents liver damage resulted from tissue injury and ischemia [39].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Omega Supplement on Induced Hepatic Mal-Function by Thioacetamide in Male Rats

Moghadamnia

Mokhtari

Khatamsaz

2017

Zahedan J Res Med Sci

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“…However, countless physiological and biochemical functions as well as its anatomic localization subject the organ in development of infectious and toxic degenerations [1,2] . liver may recover after acute degeneration, if not chronic inflammation and/or death may develop.…”

Section: Introductionmentioning

confidence: 99%

“…Free radicals are known to involve in degeneration of cellular molecules and hence play role in aging, cancer, arteriosclerosis, and cirrhosis. Omega-3 fatty acids were shown to partially protect against these conditions by inhibiting development of ischemia, inflammation and production of free radicals [2,[16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Salgı

Karaman¹,

Özen²,

Dağ³

et al. 2016

Kafkas Univ Vet Fak Derg

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Omega-3 is a polyunsaturated fatty acid known to have immunomodulatory functions. In the present study, ameliorative potential of omega-3 in experimental carbon tetrachloride (CCl4) toxicity was investigated. Total of 40 adult male Wistar albino rats were allocated into five groups and were subcutaneously given once every two days for 6 weeks the followings: Group 1 (Control): 0.5 ml/kg serum physiologic, Group 2 (Omega): 0.5 g/kg omega-3, Group 3 (Vehicle): 0.5 ml/kg pure olive oil, Group 4 (CCl4): 0.5 ml/kg CCl4, Group 5 (CCl4 + Omega): 0.5 ml/kg CCl4 plus 0.5 g/kg omega-3. At the end of the treatments, blood samples were collected and necropsy was performed for collection of liver tissues. Serum AST, AlT, GGT, TAC, TOC, triglyceride, and visfatin levels were detected. liver morphology and immunoreactivities against TGF-α, TGF-β, PPAR-α, and PPAR-γ were assessed. Serum AST, AlT, GGT, and TOC levels significantly increased while TAC level decreased in CCl4 given animals as compared to the control group. No significant changes were observed in triglyceride and visfatin levels. Immunohistochemical staining revealed increased TGF-α and TGF-β expressions and decreased PPAR-α and PPAR-γ expressions in liver of CCl4 given animals. Omega-3 supplementation has prominent effects in correcting the biochemical and immunohistochemical parameters studied as well as the tissue morphology. The results of the investigation indicated that omega-3 has ameliorative effects on the oxidative tissue degeneration and inflammatory processes induced by CCl4 treatment in rats. Keywords: CCl4, Omega-3, TGF-α, TGF-β, PPAR-α, PPAR-γ Karbon Tetraklorür Toksikasyonunda Omega-3'ün Koruyucu Etkisi ÖzetOmega-3 bağışıklığı düzenleyici fonksiyonları olduğu bilinen çoklu doymamış bir yağ asididir. Bu çalışmada, deneysel karbon tetraklorür (CCl4) toksikasyonunda omega-3'ün koruyucu potansiyel etkisi araştırılmıştır. Toplam 40 adet ergin erkek Wistar albino rat eşit beş gruba ayrıldı ve 6 hafta süresince her iki günde bir olmak üzere subkutan yolla deneklere tarif edilen uygulamalar yapıldı; Grup 1 (kontrol): 0.5 ml/kg serum fizyolojik, Grup 2 (Omega): 0.5 g/kg omega-3, Grup 3 (Taşıt): 0.5 ml/kg saf zeytin yağı, Grup 4 (CCl4): 0.5 ml/kg CCl4, Grup 5 (CCl4 + Omega): 0.5 ml/kg CCl4 artı 0.5 g/kg omega-3. Araştırma süresinin sonunda, kan örnekleri alınan deneklere karaciğer doku örneklerinin toplanması amacıyla nekropsi uygulandı. Serum AST, AlT, GGT, TAC, TOC, trigliserid ve visfatin seviyeleri belirlendi. Karaciğer morfolojisi incelendi ve TGF-α, TGF-β, PPAR-α ve PPAR-γ immunreaktiviteleri tespit edildi. Kontrol grubu ile karşılaştırıldığında CCl4 verilen hayvanlarda serum AST, AlT, GGT ve TOC seviyelerinin anlamlı derecede arttığı, TAC seviyesinin ise azaldığı gözlemlendi. Trigliserid ve visfatin seviyelerinde anlamlı bir değişikliğin olmadığı belirlendi. İmmunohistokimyasal boyamalarda CCl4 verilen hayvanlarda TGF-α ve TGF-β immunreaktiviteleri artarken PPAR-α ve PPAR-γ immunreaktivitelerinde azalma dikkati çekti. Omega-3 takviyesinin incel...

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Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids

Cited by 29 publications

References 26 publications

Protective Effects of Fish Oil Omega-3 Supplement on Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats

Protective Effects of Fish Oil Omega-3 Supplement on Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats

Protective Effects of Omega Supplement on Induced Hepatic Mal-Function by Thioacetamide in Male Rats

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