Reduction of hepatocellular carcinoma in childhood after introduction of selective vaccination against hepatitis B virus for infants born to HBV carrier mothers

Tajiri, Hitoshi; Tanaka, Hideo; Brooks, Stephen; Takano, Tomoko

doi:10.1007/s10552-010-9721-4

Cited by 35 publications

(13 citation statements)

References 14 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Infants born to infected mothers with hepatitis B were 3.5 times less likely to become infected with HBV (relative risk 0.28) using hepatitis B vaccine administered at birth [21]. The vaccine is also effective in reducing both the incidence and mortality of hepatocellular cancer [31,32].…”

Section: Discussionmentioning

confidence: 99%

Ante-natal screening of pregnant women for hepatitis B virus infection in Upper Egypt

Makhlouf¹,

Morsy²,

Othman³

et al. 2014

Egyptian Liver Journal

View full text Add to dashboard Cite

BackgroundVertical transmission of hepatitis B virus (HBV) is known to be the most common cause of perinatal infection. Purpose of the study The aim of the study was to demonstrate the prevalence and possible risk factors for HBV infection among pregnant women in upper Egypt and to target women for postpartum immunization. Patients and methods A total of 294 pregnant Egyptian women were consecutively recruited from outpatients' clinic of women healthcare center of Assiut University hospital. Clinical evaluation and questionnaire about risk factors for HBV transmission were performed. Blood samples were tested for hepatitis B surface antigen (HBsAg), antibody against hepatitis B surface (anti-HBs), and antibody against hepatitis B core (anti-HBc).Positive samples for HBsAg were tested for hepatitis B envelope antigen (HBeAg) and quantitative PCR for HBV. Newborns of HBsAg-positive mothers were tested for HBsAg immediately after labor and 9 months later. Passive-active immunization was given to newborns of HBsAg-positive mothers. ResultsThe prevalence of HBsAg among pregnant women was 4.8%. Target women for postpartum vaccination were 82.3% (those with negative anti-HBs). PCR for HBV was positive in 50% of HBsAg-positive pregnant women. None of the newborns of infected mothers were positive for HBsAg at birth and after 9 months. Previous blood transfusion, HBV infection in the family, and family history of liver disease were significant predictive factors for HBV infection in univariate analysis among Egyptian pregnant women. HBV infection in the family was the only independent predictor for HBV infection among pregnant women. ConclusionThere is an intermediate prevalence (4.8%) of HBV infection among upper Egyptian pregnant women. Family history of HBV infection is the only independent risk factor for HBV infection among pregnant women. Passive-active immunization to newborns of infected mothers resulted in 100% reduction of perinatal HBV infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Ante-natal screening of pregnant women for hepatitis B virus infection in Upper Egypt

Makhlouf¹,

Morsy²,

Othman³

et al. 2014

Egyptian Liver Journal

View full text Add to dashboard Cite

show abstract

“…Although selective vaccination of babies born from HBV‐infected mothers markedly decreased the incidence of HBV‐related HCC in childhood, as shown by our previous report, horizontal transmission of HBV also occurs in Japan . Universal HBV vaccination started in October 2016, but most children born before 2016 were not vaccinated with HBV vaccine.…”

Section: Discussionmentioning

confidence: 64%

Hepatitis B virus‐related hepatocellular carcinoma in young adults: Efficacy of nationwide selective vaccination

Yotsuyanagi

Takano

Tanaka

et al. 2020

Hepatology Research

Self Cite

View full text Add to dashboard Cite

Aim Hepatitis B vaccination in infancy was carried out in Japan only when the mother was persistently infected from 1986 to 2016. The aim of the present study was to elucidate the results of vaccination for the prevention of hepatocellular carcinoma in young adults. Methods We studied the number of patients who had liver cancer and died from 1976 to 2017 using a national database. Furthermore, we carried out a nationwide survey focusing on patients with hepatitis B virus‐related hepatocellular carcinoma who were diagnosed when aged <40 years from 2007 to 2016. Results The national database showed that the number of deaths of patients aged <40 years decreased from 337 in 1986 to 61 in 2016. Among the 122 patients with hepatocellular carcinoma (HCC) who were registered in the survey, just three patients were born after the start of the vaccination in 1986. Liver cirrhosis, defined by a high Fib‐4 index (≥3.25), was found in just 12.5% of the patients at the time of the survey. HCC was incidentally diagnosed in 85 of the 122 (69%) patients. More than 60% of the patients (54/88) were dead at the time of the study, which may be attributed to the delay in diagnosis. Conclusions Selective vaccination was effective for the prevention of hepatitis B virus‐related HCC. In contrast, many young adults who missed the chance of hepatitis B vaccination and HCC surveillance developed HCC and died. Hepatitis B virus screening in young adults and careful follow up of infected patients are important to prevent HCC development.

show abstract

“…La réponse anticorps étant conditionnée par la réponse T et la présentation des peptides antigé-niques par les molécules du complexe majeur d'histocompatibilité (CMH), des restrictions génétiques à la production d'anticorps anti-HBs, liées à certaines molécules du CMH de classe II, ont pu être mises en évidence [18]. D'autres facteurs comme le genre masculin, le surpoids, l'âge, les maladies chroniques, ou les pathologies affectant le système immunitaire, sont également impliqués dans la mauvaise réponse au vaccin telle que définie par un taux d'anticorps inférieur à 100 mUI/ml produit après un cycle complet de vaccination (2 ou 3 doses à un mois d'intervalle ont diminué de plus de 80 % chez l'enfant et le jeune adulte à Taïwan [13], au Japon [14], au Canada [15] et en Chine [16] à la suite des campagnes de vaccination massive. Malgré ces succès, la couverture vaccinale reste basse dans de nombreux pays d'Asie ou d'Afrique, principalement pour des raisons économiques.…”

Section: Le Vaccin Ses Cibles Et Son Impact Sur L'infection Et Les Munclassified

Vaccination contre l’hépatite B

Michel

2016

Med Sci (Paris)

View full text Add to dashboard Cite

Reduction of hepatocellular carcinoma in childhood after introduction of selective vaccination against hepatitis B virus for infants born to HBV carrier mothers

Abstract: The prevention program against maternal HBV infection of infants born to HBV carrier mothers may have decreased the occurrence of HBV-related HCC in childhood.

Cited by 35 publications

References 14 publications

Ante-natal screening of pregnant women for hepatitis B virus infection in Upper Egypt

Ante-natal screening of pregnant women for hepatitis B virus infection in Upper Egypt

Hepatitis B virus‐related hepatocellular carcinoma in young adults: Efficacy of nationwide selective vaccination

Vaccination contre l’hépatite B

Contact Info

Product

Resources

About