Reduction of environmental pollutants for prevention of cardiovascular disease: it’s time to act

Münzel, Thomas; Miller, Mark R.; Sørensen, Mette; Lelieveld, Jos; Daiber, Andreas; Rajagopalan, Sanjay

doi:10.1093/eurheartj/ehaa745

Cited by 53 publications

(35 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…catecholamines), which will be causing adverse changes in blood pressure, blood lipids and blood glucose. 2 As discussed earlier, a novel pathway via adverse changes in systemic inflammation or vascular inflammation only came to light recently 38 , 39 (Graphical Abstract). A study recently reported that the amygdala may be involved in processing the stress response via heightened arterial inflammation.…”

Section: Discussionmentioning

confidence: 98%

Road traffic noise and cardiovascular disease risk factors in UK Biobank

Kupcikova

Fecht

Ramakrishnan

et al. 2021

European Heart Journal

View full text Add to dashboard Cite

Aims The aim of this study was to investigate the cross-sectional associations of modelled residential road traffic noise with cardiovascular disease risk factors [systolic (SBP) and diastolic blood pressure (DBP), C-reactive protein, triglycerides, glycated haemoglobin, and self-reported hypertension] in UK Biobank. Methods and results The UK Biobank recruited 502 651 individuals aged 40–69 years across the UK during 2006–10. Road traffic noise (Lden and Lnight) exposure for 2009 was estimated at baseline address using a simplified version of the Common Noise Assessment Methods model. We used multivariable linear and logistic regression models, adjusting for age, sex, body mass index (BMI), smoking, alcohol intake, area- and individual-level deprivation, season of blood draw, length of time at residence, and nitrogen dioxide (main model), in an analytical sample size of over 370 000 participants. Exposure to road-traffic Lden >65 dB[A], as compared to ≤55 dB[A], was associated with 0.77% [95% confidence interval (CI) 0.60%, 0.95%], 0.49% (95% CI 0.32%, 0.65%), 0.79% (95% CI 0.11%, 1.47%), and 0.12% (95% CI −0.04%, 0.28%) higher SBP, DBP, triglycerides, and glycated haemoglobin, respectively. Removing BMI from the main model yielded significant positive associations with all five markers with elevated percent changes. The associations with SBP or DBP did not appear to be impacted by hypertension medication while a positive association with prevalent self-reported hypertension was seen in the non-medicated group who exposed to a Lden level of 60–65 dB[A] (odds ratio 1.07, 95% CI 1.00, 1.15). Conclusion Exposure to road traffic noise >65 dB[A], independent of nitrogen dioxide, was associated with small but adverse changes in blood pressure and cardiovascular biochemistry.

show abstract

Section: Discussionmentioning

confidence: 98%

Road traffic noise and cardiovascular disease risk factors in UK Biobank

Kupcikova

Fecht

Ramakrishnan

et al. 2021

European Heart Journal

View full text Add to dashboard Cite

show abstract

“…In the setting of traffic noise, a variety of mitigation strategies are proposed, such as developing and using low-noise tires, quiet engines, and breaks, applying quiet surfaces, installing noise barriers in densely populated areas, introducing adequate speed limits (in particular during sleeping hours), minimizing the overlap of traffic routes and housing zones, introducing night bans, installing sound-reducing windows, and placing sleeping rooms towards the quiet side of the house. Current approaches to mitigate air pollution exposure are mainly focused on personal actions like using air filtration or face masks, avoiding exposure by changing travel routes, staying indoors/closing windows, modification of outdoor activities, and keeping distance from areas where higher concentrations of air pollutants are expected, such as major roadways [ 180 ]. In any case, large-scale macro interventions in the long run, on a political and societal level that question the way we work and live are clearly needed to achieve sustainable success.…”

Section: Discussionmentioning

confidence: 99%

Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure

Hahad

Frenis

Kuntic

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

The World Health Organization estimates that only approximately 25% of diversity in longevity is explained by genetic factors, while the other 75% is largely determined by interactions with the physical and social environments. Indeed, aging is a multifactorial process that is influenced by a range of environmental, sociodemographic, and biopsychosocial factors, all of which might act in concert to determine the process of aging. The global average life expectancy increased fundamentally over the past century, toward an aging population, correlating with the development and onset of age-related diseases, mainly from cardiovascular and neurological nature. Therefore, the identification of determinants of healthy and unhealthy aging is a major goal to lower the burden and socioeconomic costs of age-related diseases. The role of environmental factors (such as air pollution and noise exposure) as crucial determinants of the aging process are being increasingly recognized. Here, we critically review recent findings concerning the pathomechanisms underlying the aging process and their correlates in cardiovascular and neurological disease, centered on oxidative stress and inflammation, as well as the influence of prominent environmental pollutants, namely air pollution and traffic noise exposure, which is suggested to accelerate the aging process. Insight into these types of relationships and appropriate preventive strategies are urgently needed to promote healthy aging.

show abstract

“…The central government in China, like many other developing countries, has adopted a green environment-friendly policy to help sustaining economic transition and modernization [42]. However, in the coming 1-2 decades, PM2.5 air pollution could still exceed the safe level of <20µg/m 3 advocated by WHO, and accordingly would pose an important environmental problem compared with many countries in the western world [43]. While traditional risk factors should be dealt with and optimally addressed, our present study proposes, in addition, emphasis on both air pollution and metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Independent Effects of Metabolic Syndrome and Air Pollution (PM2.5) on Atherosclerosis in Modernizing China

KS¹,

KCY²,

Chook³

et al. 2021

austinjpublichealthepidemiol

View full text Add to dashboard Cite

Background: Air Pollution (AP) and metabolic syndrome (MS) are important global health hazards of the 21st century, in mainland China in particular, and AP has been associated with increased prevalence of cardiovascular diseases, and stroke. Methods: To evaluate the impact of metabolic syndrome on AP-related atherogenesis, 1557 Han Chinese adults (mean age 47.2±11.8 years, male 47%) in Hong Kong, Macau, Pun Yu, Yu County (Shanxi coalmine) and 3-Gorges (Yangtze River) were studied. Cardiovascular risk profiles and metabolic syndrome (IDF criteria) were evaluated. PM2.5 (satellite sensor modeling), and atherosclerotic surrogates, brachial reactivity (FMD) and carotid Intima-media thickness (IMT) (ultrasound), were measured. Results: The yearly PM2.5 concentration ranged from 34.0μg/m³ in Hong Kong to 93.8μg/m³ in 3-Gorges Territories. MS was diagnosed in 340 subjects (21.8%). Smoking status, gender and PM2.5 were similar in the MS cohort versus those without MS. Blood pressures (SBP and DBP), waist circumference, triglycerides and glucose were higher, but high-density lipidcholesterol was lower in the MS cohort, compared to the other subjects. Brachial FMD was significantly lower and carotid IMT significantly higher (0.70±0.13 mm, 95% CI 0.68-0.71 mm vs. 0.63mm±0.14mm, 95% CI 0.62-0.64 mm) in the MS cohort than those without (P<0.0001). On multivariate regression, PM2.5 was not related to MS development, but was significantly related to carotid IMT in both no MS (beta=0.234, P<0.0001) and MS cohorts (beta=0.245, p<0.0001), independent of age, SBP, and waist circumference. There was no direct interaction between PM2.5 and MS. Conclusions: Both AP and MS have independent impacts on atherogenic processes in China, with significant implications for atherosclerosis prevention.

show abstract

Reduction of environmental pollutants for prevention of cardiovascular disease: it’s time to act

Abstract: Abstract

Cited by 53 publications

References 42 publications

Road traffic noise and cardiovascular disease risk factors in UK Biobank

Road traffic noise and cardiovascular disease risk factors in UK Biobank

Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure

Independent Effects of Metabolic Syndrome and Air Pollution (PM2.5) on Atherosclerosis in Modernizing China

Contact Info

Product

Resources

About