“…These systems use silicon photomultiplier-based detectors leading to an improved spatial and coincidence timing resolution and reduced image noise [ 180 , 181 , 182 , 183 , 184 , 185 ]. Possible clinical benefits include a reduction in administered activity or acquisition time [ 186 , 187 , 188 , 189 , 190 ] leading to increased patient comfort, particularly regarding pain-stricken or dyspneic patients [ 191 ] from which symptomatic patients with cardiotoxicity might also benefit. In addition, digital PET improves the detectability, especially of small structures and those with low tracer-uptake [ 182 , 192 , 193 , 194 ], which may facilitate the visualization of new biomarkers.…”