Reduction of dorsolateral prefrontal cortex gray matter in late-life depression

Chang, Cheng-Chen; Yu, Shun-Chieh; McQuoid, Douglas R.; Messer, Denise F.; Taylor, Warren D.; Singh, Kulpreet; Boyd, Brian D.; Krishnan, K. Ranga; MacFall, James R.; Steffens, David C.; Payne, Martha E.

doi:10.1016/j.pscychresns.2011.01.003

Cited by 97 publications

(82 citation statements)

References 38 publications

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“…Since the withdrawal task mainly involves a planning process, these associations can be explained by the observed depression consequences to the frontal lobe functioning [46][47][48] . Specifically, studies have demonstrated that damage to the inferior parietal lobe, frontal lobes, or basal ganglia hamper the performance of tasks that require more of a planning process 32,49 .…”

Section: Discussionmentioning

confidence: 99%

Motor control assessment of community-dwelling older adults with depressive symptoms

Bicalho

Albuquerque

Paula

et al. 2017

Motriz: rev. educ. fis.

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-Aims:The purpose of this study was to investigate how depressive symptoms mediate different motor control requirements in elderlies and to assess the concurring effects fomented by the interaction between aging and depressive symptoms, providing indirect measures of brain functionality. Methods: Sixty-eight elderlies were paired in terms of age and gender and were equally distributed into depressed and nondepressed groups, according to their score on the Beck Depression Questionnaire. The participants performed the Grooved Pegboard Test placing and withdrawing pegs while execution time and error rate were measured. Results: This investigation revealed that depressive symptoms exert a broad effect upon motor control, although that the symptom intensity, as well as the interaction between aging and depression intensity, were exclusively correlated with withdrawal task, suggesting that there is a greater effect upon motor acts with higher frontal lobe requirements. Conclusion: The discrimination of motor control aspects provides a valuable contribution for the understanding of the underlying neurophysiology of the interaction between aging and depression as it represents an indirect measure of cerebral dysfunction. Further, these findings may still have clinical implications, as they can promote more rational approaches to the elaboration of preventive measures that help maintain the functional capability of depressed elderlies.

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Section: Discussionmentioning

confidence: 99%

Motor control assessment of community-dwelling older adults with depressive symptoms

Bicalho

Albuquerque

Paula

et al. 2017

Motriz: rev. educ. fis.

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“…As previously reported (Chang et al, 2011), this process uses a probability atlas to guide an iterative analysis to identify different tissue types by differences in intensity across the four acquisitions. WMLs are detected as “outliers” to the normal tissue distributions.…”

Section: Methodsmentioning

confidence: 99%

Cingulum bundle white matter lesions influence antidepressant response in late-life depression: A pilot study

Taylor

Kudra

Zhao

et al. 2014

Journal of Affective Disorders

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Background Late-life depression is associated with white matter hyperintense lesions (WMLs) occurring in specific fiber tracts. In this study, we sought to determine if greater WML severity in the cingulum bundle or uncinate fasciculus was associated with poor short-term antidepressant response. Methods Eleven depressed elders completed a baseline cranial 3T MRI and received antidepressant treatment following a medication algorithm. MRIs were analyzed to measure the fraction of each fiber tract’s volume occupied by WMLs. Statistical analyses examined the effect of dichotomized fiber tract WML severity on three- and six-month depression severity after controlling for age and baseline depression severity. Results Greater WML severity in the left hemispheric cingulum bundle adjacent to the hippocampus was associated with greater post-treatment depression severity at three- (F1,7=6.42, p=0.0390) and six-month assessments (F1,5=9.62, p=0.0268). Other fiber tract WML measures were not significantly associated with outcomes. Limitations The study had a small sample size and analyses were limited to only a priori fiber tracts. Conclusions This pilot study supports the hypothesis that focal damage to the cingulum bundle may contribute to poor short-term antidepressant response. These findings warrant further investigation with a larger, more definitive study.

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“…However, given the differences observed between healthy controls and sufferers of depression, replication of results obtained in depression studies cannot necessarily be anticipated. Numerous studies highlight changes in functional connectivity and grey and white matter density, of cortical and subcortical structures (Amico et al 2011;Chang et al 2011;Davis 2004;Lacerda et al 2004;Martinot et al 2011;Taylor et al 2004), which would influence current density and flow through prefrontal structures (Shahid et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

et al. 2017

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second-daily (n = 21). In a second experiment, we separately investigated the influence of reversed polarity upon these same measures, in response to acute stimulation (n = 23) and repeated stimulation (n = 11). We observed a systematic elevation of mood in both active conditions following single and repeated tDCS, the latter of which displayed a progressive elevation of mood from baseline. No mood change was noted in response to either single or repeated stimulation in the sham condition. Frontocerebellar tDCS stimulation advantageously influences mood in healthy participants, with an accumulative and potentiated effect following successive stimulations. The possibility that frontocerebellar stimulation may provide a novel therapeutic adjunctive or pre-emptive intervention in stress-related disorders and mood-related psychopathologies should be considered.

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Reduction of dorsolateral prefrontal cortex gray matter in late-life depression

Cited by 97 publications

References 38 publications

Motor control assessment of community-dwelling older adults with depressive symptoms

Motor control assessment of community-dwelling older adults with depressive symptoms

Cingulum bundle white matter lesions influence antidepressant response in late-life depression: A pilot study

Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

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