Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations

Malatyńska, Ewa; Pinhasov, Albert; Crooke, Jeffrey J.; Smith‐Swintosky, Virginia L.; Brenneman, Douglas E.

doi:10.1016/j.jneumeth.2007.05.035

Cited by 40 publications

(42 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When treated with antidepressant medications such as imipramine, desipramine and fluoxetine, submissive rats become more assertive, resulting in a significantly greater access to the food after 2 to 4 weeks of treatment. Conversely, dominant rats injected with lithium, carbamazepine or valproate become less aggressive and lose their dominant status (Malatynska and Knapp, 2005, Malatynska et al, 2007). In addition, the mood stabilizers exert an effect over a time course that is similar to that observed in bipolar patients in that lithium and carbamazepine treatment reduced rodent dominance only after 2–3 weeks of treatment.…”

Section: Environmental Models Of Maniamentioning

confidence: 99%

Animal models of bipolar mania: The past, present and future

2016

View full text Add to dashboard Cite

Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the World Health Organization and affects nearly 6 million (~2.5% of the population) adults in the United State alone each year. BD is primarily characterized by mood cycling of depressive (e.g., helplessness, reduced energy and activity, and anhedonia) and manic (e.g., increased energy and hyperactivity, reduced need for sleep, impulsivity, reduced anxiety and depression), episodes. The following review describes several animal models of bipolar mania with a focus on more recent findings using genetically modified mice, including several with the potential of investigating the mechanisms underlying ‘mood’ cycling (or behavioral switching in rodents). We discuss whether each of these models satisfy criteria of validity (i.e., face, predictive, and construct), while highlighting their strengths and limitations. Animal models are helping to address critical questions related to pathophysiology of bipolar mania, in an effort to more clearly define necessary targets of first-line medications, lithium and valproic acid, and to discover novel mechanisms with the hope of developing more effective therapeutics. Future studies will leverage new technologies and strategies for integrating animal and human data to reveal important insights into the etiology, pathophysiology, and treatment of BD.

show abstract

Section: Environmental Models Of Maniamentioning

confidence: 99%

Animal models of bipolar mania: The past, present and future

2016

View full text Add to dashboard Cite

show abstract

“…These animals were developed based on dominantsubmissive relationship model used for psychotropic drug screening [31][32][33][34]. Our recent studies demonstrated that these animals differentially react to acute diazepam administration: while submissive animals showed obvious anxiolytic and sedative response to diazepam administration dominant mice demonstrated paradoxical response that was manifested in anxiogenic and hyperactive behavior [30].…”

Section: Introductionmentioning

confidence: 99%

Exploring diazepam’s effect on hemodynamic responses of mouse brain tissue by optical spectroscopic imaging

Abookasis

Shochat

Nesher

et al. 2014

Biomed. Opt. Express

Self Cite

View full text Add to dashboard Cite

Abstract:In this study, a simple duel-optical spectroscopic imaging apparatus capable of simultaneously determining relative changes in brain oxy-and deoxy-hemoglobin concentrations was used following administration of the anxiolytic compound diazepam in mice with strong dominant (Dom) and submissive (Sub) behavioral traits. Three month old mice (n = 30) were anesthetized and after 10 min of baseline imaging, diazepam (1.5 mg/kg) was administered and measurements were taken for 80 min. The mouse head was illuminated by white light based LED's and diffused reflected light passing through different channels, consisting of a bandpass filter and a CCD camera, respectively, was collected and analyzed to measure the hemodynamic response. This work's major findings are threefold: first, Dom and Sub animals showed statistically significant differences in hemodynamic response to diazepam administration. Secondly, diazepam was found to more strongly affect the Sub group. Thirdly, different time-series profiles were observed post-injection, which can serve as a possible marker for the groups' differentiation. To the best of our knowledge, this is the first report on the effects of an anxiolytic drug on brain hemodynamic responses in mice using diffused light optical imaging. References and links1. R. C. Kessler, P. Berglund, O. Demler, R. Jin, K. R. Merikangas, and E. E. Walters, "Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication," Arch. Gen. Psychiatry 62(6), 593-602 (2005 894-902 (2008). 4. M. T. Berlim, M. P. Fleck, and G. Turecki, "Current trends in the assessment and somatic treatment of resistant/refractory major depression: an overview," Ann. Med. 40(2), 149-159 (2008). 5. C. J. Harmer, G. M. Goodwin, and P. J. Cowen, "Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action," Br. Ntziachristos, and B. Chance, "Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument," Phys. Med. Biol. 46(1), 41-62 (2001).

show abstract

“…A constatação desta similaridade é uma importante evidência da adequação da hipótese do envolvimento do MnR na neurobiologia dos transtornos de humor, uma vez que comportamentos de dominância e submissão em roedores são considerados válidos modelos de mania e depressão (Malatynska & Knapp, 2005;Malatynska et al, 2007).…”

Section: Discussionunclassified

“…O primeiro baseia-se na manifestação natural de comportamentos de dominância e submissão em roedores para identificação de similaridades sintomatológicas e valor preditivo em relação aos transtornos maníaco e depressivo (Malatynska & Knapp, 2005;Malatynska, Pinhasov, Crooke, Smith-Swintosky, & Brenneman, 2007). Em geral, dois animais co-específicos são submetidos a condições de competição (ex.…”

Section: Modelos Animais Do Transtorno Bipolar -Episódio Maníacounclassified

“…Em geral, dois animais co-específicos são submetidos a condições de competição (ex. alimento) onde se definem relações de dominância e submissão -relações estas sensíveis ao tratamento com drogas anti-maníacas (que reduzem comportamentos de dominância) e antidepressivas (que reduzem comportamentos de submissão) (Malatynska & Knapp, 2005;Malatynska et al, 2007). O segundo modelo baseia-se na administração intracerebroventricular de oubaína (derivado esteroide com propriedade de inibir a ATPase sódio-potássio).…”

Section: Modelos Animais Do Transtorno Bipolar -Episódio Maníacounclassified

See 1 more Smart Citation

Efeitos comportamentais da lesão eletrolítica da região do núcleo mediano da rafe como modelo experimental de mania no rato e no camundongo

Pezzato¹

View full text Add to dashboard Cite

Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: Technical considerations

Cited by 40 publications

References 26 publications

Animal models of bipolar mania: The past, present and future

Animal models of bipolar mania: The past, present and future

Exploring diazepam’s effect on hemodynamic responses of mouse brain tissue by optical spectroscopic imaging

Efeitos comportamentais da lesão eletrolítica da região do núcleo mediano da rafe como modelo experimental de mania no rato e no camundongo

Contact Info

Product

Resources

About