Reduction of CD19 autoimmunity marker on B cells of paediatric SLE patients through repressing PU.1/TNF-α/BAFF axis pathway by miR-155

Wang

2019

ExRNA

Since the discovery of extracellular RNA (exRNA), it has been shown that exRNAs play a significant role as a transducer in intercellular communication and biomarkers in various diseases. Systemic lupus erythematosus (SLE) is a kind of autoimmune disease that has protean manifestations. The survival and long-term prognosis of patients with SLE has improved in these 5-10 years, while disease pathogenesis is still not clear. Many researchers found the changes in exRNA profile, and exRNAs are likely participating in the process of SLE. In this review, we summarize the current profile and function of exRNA in SLE. Circulating miRNAs, in particular, have been identified as biomarkers for SLE diagnosis. We also explore the function of lncRNA in SLE and the potential correlation with disease progression and activity. These studies show that exRNAs may take parts in the process of SLE and some of them can be used as diagnostic tool for SLE.

Section: Extracellular Rna and Slementioning

confidence: 73%

Extracellular RNA in systemic lupus erythematosus

Wang

2019

ExRNA

Journal of Advanced Research

“…All transfection experiments were executed in triplicates employing HiPerfect Transfection Reagent (Qiagen, Germany). All Experiments were repeated 3 times or more [14] , [28] , [30] , [31] .…”

Section: Methodsmentioning

confidence: 99%

“…Cells were analyzed on Accuri C6 or BD Canto II flok6w cytometers (BD bioscience, California, USA). Data analysis was done using FlowJo™ 10 (BD bioscience, California, USA) [31] .…”

Section: Methodsmentioning

confidence: 99%

Targeting hydrogen sulphide signaling in breast cancer

Youness

Gad

Sanber

et al. 2021

Journal of Immunology Research

“…Furthermore, epidemiological and clinical data demonstrate that unlike males, the females tend to develop severe disease [ 107 ]. This sex-differential susceptibility to SLE may be influenced by genes expressed on sex chromosomes and the level of sex hormones [ 108 – 110 ]. Several microRNAs have already been described to be affected by the estrogen levels [ 111 – 113 ].…”

Section: Microrna In Sle and Lnmentioning

confidence: 99%

“…Another study that investigated the potential of miR-155 in SLE showed that miR-155 suppresses autoimmunity through transcriptional repression of PU.1 and TNF- α , which in turn suppresses BAFF and CD19 protein expression. miR-155 decreased, therefore, the proportion of BAFF-expressing B cells and CD19 protein expression [ 110 ]. MicroRNA-155 expression was also significantly increased during the development of diffuse alveolar hemorrhage (DAH) which is rare but life-threatening complication of SLE.…”

Section: Microrna Regulating Innate Immune Responses Involved In Dmentioning

confidence: 99%

The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis

Honarpisheh

Köhler

Rauchhaupt

et al. 2018

Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), represent a family of RNA molecules that do not translate into protein. Nevertheless, they have the ability to regulate gene expression and play an essential role in immune cell differentiation and function. MicroRNAs were found to be differentially expressed in various tissues, and changes in their expression have been associated with several pathological processes. Yet, their roles in systemic lupus erythematosus (SLE) and lupus nephritis (LN) remain to be elucidated. Both SLE and LN are characterized by a complex dysfunction of the innate and adaptive immunity. Recently, significant findings have been made in understanding SLE through the use of genetic variant identification and expression pattern analysis and mouse models, as well as epigenetic analyses. Abnormalities in immune cell responses, cytokine and chemokine production, cell activation, and apoptosis have been linked to a unique expression pattern of a number of miRNAs that have been implicated in the immune pathogenesis of this autoimmune disease. The recent evidence that significantly increased the understanding of the pathogenesis of SLE drives a renewed interest in efficient therapy targets. This review aims at providing an overview of the current state of research on the expression and role of miRNAs in the immune pathogenesis of SLE and LN.