Reduction of casein-induced hypercholesterolaemia and atherosclerosis in rabbits and rats by dietary glycine, arginine and alanine

Katan, Martijn B.; Vroomen, L.H.M.; Hermus, R.J.J.

doi:10.1016/0021-9150(82)90037-5

Cited by 77 publications

(25 citation statements)

References 16 publications

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“…Sci Vitaminol mixture diets that sulfur-containing amino acids and probably glycine in the diet can influence the plasma cholesterol level. These effects of specific amino acids are not, however, unexpected since it has been reported that the plasma cholesterol level was increased by the dietary addition of methionine (1,8,9) and was decreased by the addition of cystine (8,9,25,26), glycine (9,27) or methionine plus glycine (9) in rats fed a cholesterol-containing diet.…”

Section: Discussionmentioning

confidence: 81%

Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.

Sugiyama

Ohkawa

Muramatsu

1986

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Discussionmentioning

confidence: 81%

Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.

Sugiyama

Ohkawa

Muramatsu

1986

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Katan et al (19) observed that addition of Gly to casein exhibited an extreme hypocholesterolemic effect in rabbits. The Gly content in casein is one-half that in soybean protein.…”

Section: Discussionmentioning

confidence: 99%

Effects of addition of sulfur-containing amino acids and glycine to soybean protein and casein on serum cholesterol levels of rats.

Tanaka

Sugano

1989

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of the supplementation of methionine (Met) , cystine (Cys), and glycine (Gly) to soybean protein or casein on serum and liver lipid levels were studied in rats. Rats were fed cholesterol-free diets containing 25% soybean protein or casein supplemented with 0.75% Met, 2.5% Gly, or a combination of these two for 4 weeks. The addition of Met to soybean protein caused a significant increase in serum cholesterol and this was slightly ameliorated when Gly was given simultaneously. In rats fed casein diets, serum cholesterol tended to decrease when Gly, or Met and Gly were added. A simultaneous supplementation of Met and Gly to casein resulted in a reduction of hepatic cholesterol. Cystine added at the 0.6% level did not cause demonstrable changes in lipid concentrations except for a drop in serum triglyceride of the casein group . When 2.0 Gly was added to cholesterol-enriched diets containing 20% protein , serum cholesterol decreased significantly only when the protein source was casein and the level attained was comparable to that observed in rats fed soybean protein. Liver cholesterol was also markedly decreased by the addition of Gly to casein. The results suggest a possible role of Gly in the regulation of serum cholesterol levels by dietary protein. Key Words soybean protein, casein, methionine, cystine, glycine , lysine, arginine, serum cholesterol Dietary protein is one of the factors influencing serum cholesterol levels (1-4). The factors responsible for the hypocholesterolemic effect of dietary protein remain unclear. Kritchevsky (5, 6) suggested that the arginine/lysine (Arg/Lys) ratio of dietary protein is an important factor in the regulation of cholesterol metabolism, although several data conflicting with the importance of this ratio are available

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“…The experimental conditions, however, were variable and no generally accepted explanation has yet been given for this effect. Certain authors have suggested that it was due to the lysine/arginine ratio (Kritchevsky et al, 1982), or the presence of other amino acids (Katan et al, 1982), while others have proposed that the fiber (Sharma, 1987) or saponin (Oakenfull et al, 1984) contents, the presence of lecithin (Jenkins et al, 1983), the polyunsaturated/ mono-unsaturated fatty acid ratio (Dunn and Liebman, 1986), or the level of phytosterols (Pollak and Kritchevsky, 1981) or trace elements (Samman and Roberts, 1984) were involved.…”

Section: Introductionmentioning

confidence: 99%

Effect of germinated and heated soybean meals on plasma cholesterol and triglycerides in rats

Chandrasiri

Bau²,

Villaume³

et al. 1990

Reprod. Nutr. Dévelop.

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Reduction of casein-induced hypercholesterolaemia and atherosclerosis in rabbits and rats by dietary glycine, arginine and alanine

Cited by 77 publications

References 16 publications

Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.

Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.

Effects of addition of sulfur-containing amino acids and glycine to soybean protein and casein on serum cholesterol levels of rats.

Effect of germinated and heated soybean meals on plasma cholesterol and triglycerides in rats

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