Reduction of C. jejuni may require complex approach

Ushanov, Leonid

doi:10.1016/j.aasci.2018.07.001

Cited by 2 publications

(3 citation statements)

References 31 publications

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“…Several therapeutic and preventive strategies have been developed against C. jejuni colonization in poultry ( 159 , 160 , 162 – 164 ). In a study, biodegradable and biocompatible poly (lactide-co-glycolide) (PLGA) compound was used to prepare nanoparticle and then the synthesized nanoparticles were wrapped with outer membrane proteins of C. jejuni .…”

Section: Methicillin-resistant Staphylococcus Aureus ...mentioning

confidence: 99%

Cell membrane-coated nanoparticles: An emerging antibacterial platform for pathogens of food animals

Altaf

Alkheraije

2023

Front. Vet. Sci.

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Bacterial pathogens of animals impact food production and human health globally. Food animals act as the major host reservoirs for pathogenic bacteria and thus are highly prone to suffer from several endemic infections such as pneumonia, sepsis, mastitis, and diarrhea, imposing a major health and economical loss. Moreover, the consumption of food products of infected animals is the main route by which human beings are exposed to zoonotic bacteria. Thus, there is excessive and undue administration of antibiotics to fight these virulent causative agents of food-borne illness, leading to emergence of resistant strains. Thus, highprevalence antibiotic-resistant resistant food-borne bacterial infections motivated the researchers to discover new alternative therapeutic strategies to eradicate resistant bacterial strains. One of the successful therapeutic approach for the treatment of animal infections, is the application of cell membrane-coated nanoparticles. Cell membranes of several different types of cells including platelets, red blood cells, neutrophils, cancer cells, and bacteria are being wrapped over the nanoparticles to prepare biocompatible nanoformulations. This diversity of cell membrane selection and together with the possibility of combining with an extensive range of nanoparticles, has opened a new opportunistic window for the development of more potentially effective, safe, and immune evading nanoformulations, as compared to conventionally used bare nanoparticle. This article will elaborately discuss the discovery and development of novel bioinspired cell membrane-coated nanoformulations against several pathogenic bacteria of food animals such as Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Salmonella enteritidis, Campylobacter jejuni, Helicobacter pylori, and Group A Streptococcus and Group B Streptococcus.

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Section: Methicillin-resistant Staphylococcus Aureus ...mentioning

confidence: 99%

Cell membrane-coated nanoparticles: An emerging antibacterial platform for pathogens of food animals

Altaf

Alkheraije

2023

Front. Vet. Sci.

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“…Campylobacter jejuni is a causative agent of bacterial enteritis in humans with serious consequences for children, the elderly and the immunocompromised [1][2][3]. One of the rare sequelae associated with C. jejuni is Guillain-Barré syndrome (GBS), manifested as demyelination of the peripheral nerves due to autoimmune reaction and paralysis [4,5].…”

Section: Significance Of Campylobacter Jejuni As a Pathogenmentioning

confidence: 99%

“…Thus, bacteriophage application is manifold and covers different stages of primary (live animals) and secondary (harvested meats) production in animal farm settings. Having no associated toxicity, phage treatments can be complexed with other methods, such as probiotic supplements, aimed at reduction of C. jejuni [1,4,45].…”

Section: Phage Applications Targeting Food-borne Pathogensmentioning

confidence: 99%

Application of Campylobacter jejuni Phages: Challenges and Perspectives

Ushanov

Lasareishvili

Janashia

et al. 2020

Animals

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Bacteriophages (phages) are the most abundant and diverse biological entities in the biosphere. Due to the rise of multi-drug resistant bacterial strains during the past decade, phages are currently experiencing a renewed interest. Bacteriophages and their derivatives are being actively researched for their potential in the medical and biotechnology fields. Phage applications targeting pathogenic food-borne bacteria are currently being utilized for decontamination and therapy of live farm animals and as a biocontrol measure at the post-harvest level. For this indication, the United States Food and Drug Administration (FDA) has approved several phage products targeting Listeria sp., Salmonella sp. and Escherichia coli. Phage-based applications against Campylobacter jejuni could potentially be used in ways similar to those against Salmonella sp. and Listeria sp.; however, only very few Campylobacter phage products have been approved anywhere to date. The research on Campylobacter phages conducted thus far indicates that highly diverse subpopulations of C. jejuni as well as phage isolation and enrichment procedures influence the specificity and efficacy of Campylobacter phages. This review paper emphasizes conclusions from previous findings instrumental in facilitating isolation of Campylobacter phages and improving specificity and efficacy of the isolates.

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Reduction of C. jejuni may require complex approach

Cited by 2 publications

References 31 publications

Cell membrane-coated nanoparticles: An emerging antibacterial platform for pathogens of food animals

Cell membrane-coated nanoparticles: An emerging antibacterial platform for pathogens of food animals

Application of Campylobacter jejuni Phages: Challenges and Perspectives

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