Reduction of Broad-Spectrum Antimicrobial Use in a Tertiary Children’s Hospital Post Antimicrobial Stewardship Program Guideline Implementation*

Lee, Kelley R.; Bagga, Bindiya; Arnold, Sandra R.

doi:10.1097/pcc.0000000000000615

Cited by 63 publications

(88 citation statements)

References 6 publications

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“…In human medicine, antimicrobial use guidelines have been developed and implemented as one of the strategic goals to optimize antimicrobial use (Goldmann et al, 1996), and they have shown to have a positive effect on the antimicrobial prescribing behavior (Smith et al, 2012;Lee et al, 2016). In veterinary medicine, only in a limited number of studies, the impact of antimicrobial guidelines has been investigated.…”

Section: Introductionmentioning

confidence: 99%

De impact van advies omtrent het gebruik van antimicrobiële middelen op het voorschrijfgedrag in veertien Vlaamse praktijken voor kleine huisdieren

Sarrazin¹,

Vandael²,

Cleven³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

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A prospective study was performed to explore the prescription habits in fourteen first-line, small animal practices during first consultations of cats and dogs. Consultations one month prior to the implementation of antimicrobial use guidelines and at least 20 days thereafter were examined. Differences in the proportion of consultations during which antimicrobials were prescribed, were assessed. Additionally, changes in the choice of active substance were critically evaluated against the introduced antimicrobial use guidelines. The proportion of consultations where antimicrobials were prescribed decreased in cats and dogs (both –12%) after the introduction of the antimicrobial use guidelines. There was an increase of consultations of cats (+13%) and dogs (+10%) where veterinarians handled according to those guidelines. However, an increase in the prescription of third-choice antimicrobials and highest priority critically important antimicrobials was noticed both in cats (+8% and +12%, respectively) and dogs (both +5%). This unexpected increase invites to create extra awareness amongst prescribers.

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Section: Introductionmentioning

confidence: 99%

De impact van advies omtrent het gebruik van antimicrobiële middelen op het voorschrijfgedrag in veertien Vlaamse praktijken voor kleine huisdieren

Sarrazin¹,

Vandael²,

Cleven³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

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show abstract

“…Findings of other similar studies in Singapore, Iran and US in hospitalized children and women showed that the proper prescription of carbapenems using the ASP was increased significantly, also proved that the ASP protocol can be successfully applied to promote quality of care of hospitalized patients (22,25,26).…”

Section: Discussionmentioning

confidence: 66%

Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridium difficile infection and amount of antimicrobial consumed in cancer patients

Mardani

Abolghasemi

Shabani

2019

Preprint

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Objective: The objective of this study was to determine the impact of a hospital antimicrobial stewardship on antimicrobial resistant, clostridium difficile rates and amount of antimicrobial consumed in cancer patients. The intervention effects of ASP plans in 2017-2018 and 2018-2019 were respectively evaluated among hematology/oncology and bone morrow transplant patients in Ayatollah Taleghani University Hospital, Tehran, Iran. In this interventional quasi-experimental study, the ASP repository was utilized to capture four survey questions encompassed in these immunocompromised patients: amount of antibiotics (MPM and VMN) consumption gr-year, number of positive clostridium difficile infection and multidrug resistant positive cases in blood cultures.Results: The number of MDR cases in the time periods of 2017-2018 and 2018-2019 were 145 and 75, respectively (p = 0.011). A significant reduction in positive blood cultures from 2017-2018 to 2018-2019 was found (p = 0.001).The amount of MPM prescriptions in 2018-2019 was significantly decreased from 22464 to 17262 g (p = 0.043). The significant reduction in antibiotic consumption, MDR organisms and CDI can highly promote patients' health and decreasing medical costs and longterm defects for patients. Finally, future stewardship studies should made efforts for joining clinical and epidemiological studies.

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“…Other similar studies in Singapore, Iran, and the US in hospitalized children and women showed that the proper prescription of carbapenems using the ASP was increased significantly, also proved that the ASP protocol can be successfully applied to promote quality of care of hospitalized patients (22,25,26).…”

Section: Discussionmentioning

confidence: 67%

Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridioides difficile infection and amount of antimicrobial consumed in cancer patients

Mardani

Abolghasemi

shabani³

2020

Preprint

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Objective: The The impact of a hospital antimicrobial stewardship was determined on antimicrobial-resistant, Clostridioides difficile rates and the amount of antimicrobial consumed in cancer patients.The intervention effects of antimicrobial stewardship (ASP) plans in 2017–2018 and 2018–2019 were respectively evaluated among hematology/oncology and bone marrow transplant patients in Ayatollah Taleghani University Hospital, Tehran, Iran. In this interventional quasi-experimental study, the ASP repository was utilized to capture four survey questions encompassed in these immunocompromised patients: amount of antibiotics (meropenem and vancomycin) consumption gr-year, the number of positive Clostridioides difficile infection and multidrug-resistant positive cases in blood cultures. Results: The number of MDR cases in the periods of 2017–2018 and 2018–2019 were 145 and 75, respectively (p = 0.011). A significant reduction in all positive blood cultures from 2017–2018 to 2018–2019 was found (p = 0.001). 574 patients admitted to our hospital in these periods of 2017- 2018 and 2018- 2019were assessed for MPM and VMN use. The amounts of MPM prescriptions in 2018–2019 was significantly decreased from 22464 to 17262 g (p = 0.043). The significant reduction in antibiotic consumption, MDR organisms, and CDI can highly promote patients’ health and decreasing medical costs and long-term defects for patients.

show abstract

Reduction of Broad-Spectrum Antimicrobial Use in a Tertiary Children’s Hospital Post Antimicrobial Stewardship Program Guideline Implementation*

Cited by 63 publications

References 6 publications

De impact van advies omtrent het gebruik van antimicrobiële middelen op het voorschrijfgedrag in veertien Vlaamse praktijken voor kleine huisdieren

De impact van advies omtrent het gebruik van antimicrobiële middelen op het voorschrijfgedrag in veertien Vlaamse praktijken voor kleine huisdieren

Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridium difficile infection and amount of antimicrobial consumed in cancer patients

Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridioides difficile infection and amount of antimicrobial consumed in cancer patients

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