Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft

Marukawa, Eriko; Oshina, Hidekazu; Iino, Gaichi; Morita, Keiichi; Omura, Ken

doi:10.1016/j.jcms.2010.04.017

Cited by 83 publications

(80 citation statements)

References 46 publications

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“…In contrast, PRP gel does not enhance the bone healing process in mandibular defects in rabbits (Kazakos et al, 2011). The results of human studies are also inconsistent (Marx et al, 1998;Wiltfang et al, 2003;Raghoebar et al, 2005, Marukawa et al, 2010. Dispute has been focused on therapeutic platelet level (Marx, 2004), intrinsic osteoinductive property (Schilephake, 2002), and mostly short-term effects, because of the quickly fading level of bioactive proteins (Schmitz and Hollinger, 2001;Marx, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study

Zhang¹,

Tangl²,

Huber³

et al. 2012

Journal of Cranio-Maxillofacial Surgery

177

172

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Section: Introductionmentioning

confidence: 99%

Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study

Zhang¹,

Tangl²,

Huber³

et al. 2012

Journal of Cranio-Maxillofacial Surgery

177

172

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“…In this study, we adapted the double spin technique and observed that the platelet count was increased about 3.5 folds and TGF-B1 was increased 2.4 folds. In a similar study, Marukawa et al [14] used the double spin technique for PRP preparation and noticed that the platelet count was increased about 3 times and the platelet released growth factors increased about 2 -3 times. Conversely, Pietrzak et al [15] suggested that a four to five fold increase in the baseline of platelet count is needed but they show no clear evidence that lower or higher concentration may decrease or increase the positive effect of PRP.…”

Section: Discussionmentioning

confidence: 98%

Clinical Safety and Efficacy of Platelet-Rich Plasma in Wound Healing

Ghoraba¹,

Mahmoud²,

Hammad³

et al. 2016

IJCM

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Background: Platelet-rich plasma has been extensively used in several clinical settings. However, there still a lack of conclusive evidence concerning the benefits of platelet-rich plasma in the field of wound healing. We aimed to evaluate the safety and the efficacy of autologous platelet-rich plasma in acute wound healing. Methods: This prospective study enrolled forty adult patients of both sexes and aged between 18 -50 years. All patients in need for split-thickness skin graft were included in our study. The donor sites were randomly divided into two equal halves: the platelet-rich plasma side, which was injected with recently activated platelet-rich plasma; and the control side, in which the conventional method of dressing was used. Measurement of the platelet count and transforming growth factor-B1 concentration in each platelet-rich plasma preparation and the whole blood was done for all patients. Clinical monitoring of the donor sites was done every 7 days for 3 weeks, regarding pain perception, epithelialization surface area and possible side effects of the platelet-rich plasma. Histopathological monitoring was done on the 7 th postoperative day. Results:The platelet count was increased about 3.5 folds and transforming growth factor-B1 was increased 2.4 folds in the platelet-rich plasma compared to the patients' blood. The platelet-rich plasma side had significantly lower pain scores at day 7 (4.8 ± 0.18 vs 5.9 ± 0.07) and day 14 (1.4 ± 0.11 vs 1.9 ± 0.09) postoperative (p = 0.002 and p = 0.004, respectively) and had significantly higher rate of epithelialization at day 7 (9.8 ± 0.35 cm 2 vs 7.5 ± 0.32 cm 2 ) and day 14 (38.4 ± 0.36 cm 2 vs 36.9 ± 0.42 cm 2 ) postoperative (p < 0.001 and p = 0.039, respectively), while at day 21 postoperative, there was no significant difference between both sides. There was no significant difference between both sides regarding the incidence of complications. The platelet-rich plasma side showed intact epithelium, differentiation of the cells in stratum spongiosum and stratum granulosum, neovascularization and earlier collagen deposition. Conclusion:The platelet-rich plasma is safe and effective adjuvant in the management of acute wounds. However, we recommend for larger clinical trials for standardized method for PRP preparation and better understanding of the efficacy of this blood product.

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“…10 Patients with cleft lip and palate require prolonged interdisciplinary approach and long-term follow-up to establish a final result. 7 In early stages of cleft palate repair, bone grafts are usually used in closing the bony defects. 6 In most of the cases, resorption of the graft occurs because of excessive tension in the mucoperiosteum and absence of physiologic stress by the erupting teeth 4 , which ultimately results in inadequate coverage or severe scarring of the palate; 1 But 78.5% of surgeons prefer to do Lefort 1 osteotomy with advancement in patients who had already undergone primary closure of unilateral cleft lip and palate with maxillary hypoplasia.…”

Section: Discussionmentioning

confidence: 99%

A Case of Cleft Hypoplastic Maxilla corrected by Single-stage Lefort 1 Osteotomy to improve Esthetics and Function

Christopher¹,

Gughan²,

Devadoss³

et al. 2015

Journal of Health Sciences &Amp; Research

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Among the congenital anomalies, cleft lip and palate take about 14% of the total population; among them, unilateral cleft lip and palate is predominant than bilateral. Cleft lip correction preceding the cleft palate is usually done within a gap of 3 years. Due to the wide median palatal cleft, a perfectly performed Langenbeck pushback closures can leave behind persistent oronasal fistulas during the healing process, due to which severe scarring of palatal mucosa takes place. Secondary alveolar grafting is a procedure performed irrespective of the age for persistent oronasal fistulas. Further closure of nasal and palatal fistula with intervening bone graft is always successful but can compromise the growth of maxilla resulting in hypoplasia. In one such case of a failed secondary alveolar grafting, a Lefort 1 advancement alone was done not only to improve the facial esthetics but also function. This paper discusses in detail the comprehensive surgical procedure performed.

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Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft

Cited by 83 publications

References 46 publications

Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study

Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study

Clinical Safety and Efficacy of Platelet-Rich Plasma in Wound Healing

A Case of Cleft Hypoplastic Maxilla corrected by Single-stage Lefort 1 Osteotomy to improve Esthetics and Function

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