Reduction of bacterial load by predonation sampling

Chassaigne, M; Vassort-Bruneau, C.; Allouch, P.; Audurier, A; Boulard, G.; Grosdhomme, F.; Noël, Laure Hélène; Gulian, C.; Janus, G.; Perez, Paul

doi:10.1016/s1473-0502(01)00066-0

Cited by 12 publications

(6 citation statements)

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“…1). At donation, blood was made to flow initially into pouch P1, which represented a diversion pouch [9]. Pouch P1 was closed using a plastic clip, causing blood to flow into pouch P2, providing a representative sample from the collection bag post-diversion.…”

Section: Methodsmentioning

confidence: 99%

ORIGINAL PAPER. Relative values of the interventions of diversion and improved donor‐arm disinfection to reduce the bacterial risk from blood transfusion

McDonald¹,

Roy²,

Mahajan³

et al. 2004

Vox Sanguinis

101

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Section: Methodsmentioning

confidence: 99%

ORIGINAL PAPER. Relative values of the interventions of diversion and improved donor‐arm disinfection to reduce the bacterial risk from blood transfusion

McDonald¹,

Roy²,

Mahajan³

et al. 2004

Vox Sanguinis

101

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“…Removal of the initial whole blood collection (diversion): It has been shown that removal of the first 30-40 ml of whole blood from the collection bag might reduce the contamination risk from skin bacteria. In fact, improved donor arm disinfection in association with blood diversion has been reported to reduce the risk of bacterial contamination by up to 77% [19][20][21].…”

Section: ) Optimal Product Processing Handling and Storagementioning

confidence: 99%

Transfusion-transmitted infections

et al. 2007

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Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human pathogens. Only continuous improvement and implementation of donor selection, sensitive screening tests and effective inactivation procedures can ensure the elimination, or at least reduction, of the risk of acquiring transfusion transmitted infections. In addition, ongoing education and up-to-date information regarding infectious agents that are potentially transmitted via blood components is necessary to promote the reporting of adverse events, an important component of transfusion transmitted disease surveillance. Thus, the collaboration of all parties involved in transfusion medicine, including national haemovigilance systems, is crucial for protecting a secure blood product supply from known and emerging blood-borne pathogens.

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“…Coring of skin or the flushing of organisms from skin flaps into the primary blood container during phlebotomy has long been recognized as a source of contamination [30,31]. Several studies have investigated the potential for diversion of the first 10–40 ml of whole blood to prevent skin plugs or flushing of organisms from skin flaps from entering the primary collection container [32–34]. The diverted whole blood can be used for viral testing and may allow collection of units that would otherwise be destroyed because of the inability to collect blood in tubes from a small percentage of donors after blood collection.…”

Section: Sources Of Contaminationmentioning

confidence: 99%

Transfusion‐transmitted bacterial infection: risks, sources and interventions

Wagner

2004

Vox Sanguinis

127

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Records of the transmission of bacterial infections by transfusion date back to the beginning of organized blood banking. Despite tremendous strides in preventing viral infection through careful donor screening and viral testing, there has been little improvement in reducing the risk of bacterial sepsis since the introduction of closed collection systems. Based on the French Haemovigilance study, the British Serious Hazards of Transmission (SHOT) study and fatality reports to the United States Food and Drug Administration, the risk of clinically apparent sepsis exceeds the risk of HIV, HBV, and HCV transmission. Sources of contamination include the skin, blood, disposables, and the environment. Potential interventions to reduce transfusion-associated bacterial sepsis include improvements to donor arm preparation, diversion of the first aliquot of whole blood, introduction of bacterial testing and/or implementation of pathogen reduction methods.

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Reduction of bacterial load by predonation sampling

Cited by 12 publications

References 0 publications

ORIGINAL PAPER. Relative values of the interventions of diversion and improved donor‐arm disinfection to reduce the bacterial risk from blood transfusion

ORIGINAL PAPER. Relative values of the interventions of diversion and improved donor‐arm disinfection to reduce the bacterial risk from blood transfusion

Transfusion-transmitted infections

Transfusion‐transmitted bacterial infection: risks, sources and interventions

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