Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia

Özgürdal, Seza; Gudlowski, Yehonala; Witthaus, Henning; Kawohl, Wolfram; Uhl, Idun; Hauser, Marta; Gorynia, Inge; Gallinat, Jürgen; Heinze, Martin; Heinz, Andreas; Juckel, Georg

doi:10.1016/j.schres.2008.05.017

Cited by 87 publications

(52 citation statements)

References 22 publications

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“…20,53 The ARMS group also showed a reduced P300 amplitude compared with controls, in line with our previous results in a larger sample 14 and with other studies in patients at risk for psychosis. 15,54 Functionally, the P300 reflects the summation of multiple, simultaneously occurring cognitive and brain processes that are linked to attentional resource allocation and memory-updating operations in the brain. 6 Consequently, the observed P300 abnormalities in the ARMS group are consistent with data from behavioural studies indicating impaired performance on tasks that engage attention and executive processes.…”

Section: Discussionmentioning

confidence: 99%

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Fusar‐Poli

Crossley

Woolley

et al. 2011

jpn

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Section: Discussionmentioning

confidence: 99%

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Fusar‐Poli

Crossley

Woolley

et al. 2011

jpn

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“…In both experimental sessions, the NSV was the standard stimulus and the SGV was the deviant in one of the blocks, whereas in the other block the reverse was observed. The standard and deviant voices were binaurally presented in a pseudorandom order, with the restriction that at least two standard stimuli lay between two deviant sounds, in line with previous studies (e.g., Özgürdal et al, 2008;Schirmer & Escoffier, 2010;Schirmer et al, 2007;Shtyrov & Pulvermüller, 2002). The Presentation software (Neurobehavioral Systems, Albany, CA, USA) was used to control stimulus timing and presentation.…”

Section: Methodsmentioning

confidence: 99%

The effects of stimulus complexity on the preattentive processing of self-generated and nonself voices: An ERP study

Conde

Gonçalves

Pinheiro

2015

Cogn Affect Behav Neurosci

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The ability to differentiate one's own voice from the voice of somebody else plays a critical role in successful verbal self-monitoring processes and in communication. However, most of the existing studies have only focused on the sensory correlates of self-generated voice processing, whereas the effects of attentional demands and stimulus complexity on self-generated voice processing remain largely unknown. In this study, we investigated the effects of stimulus complexity on the preattentive processing of self and nonself voice stimuli. Event-related potentials (ERPs) were recorded from 17 healthy males who watched a silent movie while ignoring prerecorded self-generated (SGV) and nonself (NSV) voice stimuli, consisting of a vocalization (vocalization category condition: VCC) or of a disyllabic word (word category condition: WCC). All voice stimuli were presented as standard and deviant events in four distinct oddball sequences. The mismatch negativity (MMN) ERP component peaked earlier for NSV than for SGV stimuli. Moreover, when compared with SGV stimuli, the P3a amplitude was increased for NSV stimuli in the VCC only, whereas in the WCC no significant differences were found between the two voice types. These findings suggest differences in the time course of automatic detection of a change in voice identity. In addition, they suggest that stimulus complexity modulates the magnitude of the orienting response to SGV and NSV stimuli, extending previous findings on self-voice processing.

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“…The P300 event-related potential (ERP), typically elicited with an auditory oddball paradigm, is impaired in patients with schizophrenia (McCarley et al, 1993;Mathalon et al, 2000) and also in first-episode patients (de Wilde et al, 2008), prodromal individuals (Bramon et al, 2008;Ozgurdal et al, 2008) and in those at-risk for psychosis (Frangou et al, 1997;Winterer et al, 2003;Frommann et al, 2008;van Tricht et al, 2010). Although the P300 component is usually thought to reflect memory updating and the allocation of attentional resources, this component can also offer insight into language processing Jeon and Polich, 2003).…”

Section: Introductionmentioning

confidence: 99%

Language processing abnormalities in adolescents with psychotic-like experiences: An event related potential study

Murphy

Blanchard

Rawdon

et al. 2012

Schizophrenia Research

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Language impairments are a well established finding in patients with schizophrenia and in individuals at-risk for psychosis. A growing body of research has revealed shared risk factors between individuals with psychotic-like experiences (PLEs) from the general population and patients with schizophrenia. In particular, adolescents with PLEs have been shown to be at an increased risk for later psychosis. However, to date there has been little information published on electrophysiological correlates of language comprehension in this at-risk group. A 64 channel EEG recorded electrical activity while 37 (16 At-Risk; 21 Controls) participants completed the British Picture Vocabulary Scale (BPVS-II) receptive vocabulary task. The P300 component was examined as a function of language comprehension. The at-risk group were impaired behaviourally on receptive language and were characterised by a reduction in P300 amplitude relative to the control group. The results of this study reveal electrophysiological evidence for receptive language deficits in adolescents with PLEs, suggesting that the earliest neurobiological changes underlying psychosis may be apparent in the adolescent period.

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Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia

Cited by 87 publications

References 22 publications

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

The effects of stimulus complexity on the preattentive processing of self-generated and nonself voices: An ERP study

Language processing abnormalities in adolescents with psychotic-like experiences: An event related potential study

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