Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patients

The significance of lipid peroxidation in cardiovascular disease

“…10,24]. In the present metabolic syndrome study, changes in nanoplaque formation were well correlated to changes in oxLDL/LDL ratio (r = 0.83; p < 0.0210).…”

“…In a number of investigations [1,[3][4][5][6][7][8][9][10], a good correlation has been observed between in vivo biomarkers and risk factors, on one hand, and lipoprotein risk factor deposition to HS-PG under accelerated in vitro conditions. While the latter could most realistically be performed with endothelial cells adhered to methylated silica surfaces for ellipsometry and microscopy, analogous results were found with simpler and more robust endothelial model surfaces, in which HS-PG was simply adsorbed to methylated silica surfaces [13].…”

“…Ellipsometry, photometric methods, commercial ELISAs and EIAs, all described previously, were applied [1,3,5,10,17]. In the ellipsometry measurements, the adsorbed amount was determined according to de Feijter using a refractive index increment of dn/dc = 0.16 cm 3 /g (Fig.…”

“…A c c e p t e d M a n u s c r i p t 9 distribution using t = r sqrt [(n -2)/(1 -r 2 )], where n is the number of data points and n -2 the degree of freedom. A correlation between two data sets is significant if the two-sided probability p < 0.05 [5,10,17].…”

“…Our clinical trials with statins [3,4], ginkgo [6,10], ω3-fatty acids [11] and blackcurrant extract [12] unravelled this network of biomarker interactions and demonstrated its usefulness for theranostics.…”