Reduction of Allergic Skin Responses and Serum Allergen-Specific IgE and IgE-Inducing Cytokines by Drinking Deep-Sea Water in Patients with Allergic Rhinitis

Kimata, Hajime; Tai, Hideyuki; Nakajima, Hiroshi

doi:10.1159/000068306

Cited by 14 publications

(14 citation statements)

References 5 publications

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“…DSW also has been reported to contain high levels of minerals, such as magnesium (Mg), calcium (Ca), and potassium (K) compared with surface and middle-sea water (Katsuda et al, 2008;Toyota & Nakashima, 1998). The biological functions of DSW have been investigated for various uses, including attenuating hyperlipidaemia, as well as atherosclerosis, dermatitis syndrome and allergic skin responses (Hataguchi, Tai, Nakajima, & Kimata, 2005;Kimata, Tai, & Nakajima, 2001;Miyamura et al, 2004;Ueshima, Fukao, Okada, & Matsuo, 2003;Yoshioka et al, 2003). Nagai et al (2006) indicated that intake of Mg from DSW delays cataract development in the shumiya cataract rat.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters

et al. 2011

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“…They found no significant differences in those values between the desalted DSW and purified water groups. However, Kimata et al (2002) found that natural DSW drinking can be used to reduce skin allergy in humans. In addition, Weetman et al (1983) reported that iodine could increase IgG synthesis in human lymphocytes in vitro.…”

Section: The Relative Weight Of the Lymphoid Organs And Serum Immunogmentioning

confidence: 99%

“…Tai et al (2000) also reported that drinking DSW in healthy volunteers showed significant decrease in both whole blood flow time and blood pressure. Kimata et al (2002) suggested that DSW intake decreases serum total and allergen-specific Ig E levels by reducing Ig E-inducing cytokines production. Although there was no statistical difference, the current result proposed there could be RO-DSW induced immune stimulator.…”

Section: The Relative Weight Of the Lymphoid Organs And Serum Immunogmentioning

confidence: 99%

“…However, there are only limited numbers of scientific literatures available that had evaluated DSW with experimental animals. Although some studies have examined the characteristics of natural DSW (Suzuki, 2000;Kimata et al, 2002;Ueshima et al, 2003), the efficacy of DSW has not clearly been elucidated yet. Suzuki (2000) found that deep sea water had an effect of decreasing serum total carbohydrate levels in mice.…”

Section: Introductionmentioning

confidence: 99%

“…Suzuki (2000) found that deep sea water had an effect of decreasing serum total carbohydrate levels in mice. Kimata et al (2002) reported that drinking of treated deep sea water was effective to reduce skin allergy. But it is also reported that the desalted DSW can be evaluated just safe as the ordinary purified water for drinking (Tsuchiya et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Drinking Reverse-osmosis Treated Deep Sea Water on Growth Performance and Immune Response in Broiler Chickens

Keohavong¹,

Lee²,

Lee³

et al. 2010

Journal of Animal Science and Technology

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This study was executed to investigate the effects of drinking deep sea water treated by reverse osmosis process (RO-DSW) on growth performance, nutrient utilizability, relative weight of lymphoid organs and the concentration of serum immunoglobulin G (IgG) in broiler chickens. A total of 200 one day old broiler chickens (Ross 308) were equally and randomly distributed into 10 ground floor pens (20 chicks per pen, 5 pens per treatment) bedded with rice-husks. The broilers were offered either fresh tap water (Control) or RO-DSW for 28 days (from d 6 to d 33) as the drinking water. The same basal phase 1 diet for first 2 weeks and phase 2 diet for last 2 weeks were offered ad libitum to the birds. The RO-DSW was prepared by diluting 1:20 ratio with deionized water before offering to chickens. The diet for control birds was supplemented with 0.21 % of food-grade salt to satisfy salt need of the birds. Broiler feeding study resulted that there were no differences in amount of water consumption, mortality and FCR between RO-DSW and control chickens. However, feed intake and body weight gain were increased (p<0.05) by RO-DSW drinking. There was no (p>0.05) difference in nutrients utilizability between RO-DSW and fresh water drinking. There were no (p>0.05) differences in the immune response between the control and treatment group. The serum IgG levels were 3.01 vs 2.87 mg/ml and the relative weights of spleen, thymus and bursa of Fabricius were 0.23, 0.18 and 0.20 vs. 0.20, 0.17 and 0.14 for RO-DSW vs. control birds, respectively. The immune responses were tended to be improved by RO-DSW drinking. This study showed an improvement in weight gain and feed intake that could be induced by RO-DSW drinking, although it is difficult to explain the reasons of the improvement at this moment. This study implied that RO-DSW could be successfully used as drinking water to broiler chickens.

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Drinking deep-sea water restores mineral imbalance in atopic eczema/dermatitis syndrome

Hataguchi¹,

Tai²,

Nakajima³

et al. 2005

Eur J Clin Nutr

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Objective: The effect of drinking deep-sea water on hair minerals was studied in patients with atopic eczema/dermatitis syndrome (AEDS). Study of hair minerals revealed an imbalance of essential minerals and an increase in toxic minerals in AEDS patients. Design: After drinking deep-sea water (Amami no Mizu) for 6 months in AEDS patients, hair minerals (essential minerals and toxic minerals), clinical evaluation of the skin symptoms were compared before drinking with after drinking. Subjects: After obtaining informed consent, 33 patients (mean age 26 y, range 1-50 y, 13 male and 20 female subjects) with mild to moderate AEDS were enrolled. Results: After drinking deep-sea water, the levels of the essential mineral, potassium (K), were significantly decreased, while the levels of selenium (Se) increased. On the other hand, drinking deep-sea water significantly decreased the levels of the toxic minerals, mercury and lead. Moreover, after drinking deep-sea water, the skin symptoms were improved in 27 out of 33 patients. Conclusion: These results indicate that the mineral abnormalities/imbalance may be involved in the pathogenesis of AEDS, and that drinking deep-sea water may be useful in the treatment of AEDS.

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Reduction of Allergic Skin Responses and Serum Allergen-Specific IgE and IgE-Inducing Cytokines by Drinking Deep-Sea Water in Patients with Allergic Rhinitis

Abstract: Deep-sea water intake reduces allergic skin responses and serum levels of total IgE, Japanese cedar pollen-specific IgE, interleukin (IL)-4, IL-6, IL-13, and IL-18 in patients with allergic rhinitis, while distilled water intake fails to do so.

Cited by 14 publications

References 5 publications

Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters

Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters

Effects of Drinking Reverse-osmosis Treated Deep Sea Water on Growth Performance and Immune Response in Broiler Chickens

Drinking deep-sea water restores mineral imbalance in atopic eczema/dermatitis syndrome

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