Reduction of aggressive behaviour following hypothalamic deep brain stimulation: Involvement of 5-HT1A and testosterone

Gouveia, Flavia Venetucci; Diwan, Mustansir; Martinez, Raquel Chacon Ruiz; Giacobbe, Peter; Lipsman, Nir; Hamani, Clement

doi:10.1016/j.nbd.2023.106179

Cited by 5 publications

(1 citation statement)

References 91 publications

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“…The correct selection and location of DBS targets is the key to successful operation. 9 At present, the commonly used targets for DBS are the STN, GPi and VIM. Among them, STN and Gpi mainly improve the clinical symptoms (resting tremor, myotonia and bradykinesia) of PD patients.…”

Section: Discussionmentioning

confidence: 99%

Vim-PSA Double-Target DBS for the Treatment of Holmes Tremor Secondary to Brainstem Hemorrhage: A Case Report

Chong,

Yang,

Peng

et al. 2024

IMCRJ

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We report the case of a 53-year-old man who was diagnosed with Holmes tremor and underwent deep brain stimulation of the ventro-intermediate thalamic nucleus and posterior subthalamic area. We assessed the patients’ tremor with the Fahn-Tolosa-Marin Tremor Rating Scale at 1, 3, 6, 12 and 24 months after deep brain stimulation. Deep brain stimulation relieved the patient’s tremor during the 24-month follow-up period.

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Section: Discussionmentioning

confidence: 99%

Vim-PSA Double-Target DBS for the Treatment of Holmes Tremor Secondary to Brainstem Hemorrhage: A Case Report

Chong,

Yang,

Peng

et al. 2024

IMCRJ

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Immunomodulatory and endocrine effects of deep brain stimulation and spinal cord stimulation – A systematic review

Puk,

Jabłońska,

Sokal

2023

Biomedicine & Pharmacotherapy

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Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders

Zhang,

Matin,

Gorodetsky

et al. 2024

Transl Psychiatry

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Deep brain stimulation (DBS) modulates local and widespread connectivity in dysfunctional networks. Positive results are observed in several patient populations; however, the precise mechanisms underlying treatment remain unknown. Translational DBS studies aim to answer these questions and provide knowledge for advancing the field. Here, we systematically review the literature on DBS studies involving models of neurological, developmental and neuropsychiatric disorders to provide a synthesis of the current scientific landscape surrounding this topic. A systematic analysis of the literature was performed following PRISMA guidelines. 407 original articles were included. Data extraction focused on study characteristics, including stimulation protocol, behavioural outcomes, and mechanisms of action. The number of articles published increased over the years, including 16 rat models and 13 mouse models of transgenic or healthy animals exposed to external factors to induce symptoms. Most studies targeted telencephalic structures with varying stimulation settings. Positive behavioural outcomes were reported in 85.8% of the included studies. In models of psychiatric and neurodevelopmental disorders, DBS-induced effects were associated with changes in monoamines and neuronal activity along the mesocorticolimbic circuit. For movement disorders, DBS improves symptoms via modulation of the striatal dopaminergic system. In dementia and epilepsy models, changes to cellular and molecular aspects of the hippocampus were shown to underlie symptom improvement. Despite limitations in translating findings from preclinical to clinical settings, rodent studies have contributed substantially to our current knowledge of the pathophysiology of disease and DBS mechanisms. Direct inhibition/excitation of neural activity, whereby DBS modulates pathological oscillatory activity within brain networks, is among the major theories of its mechanism. However, there remain fundamental questions on mechanisms, optimal targets and parameters that need to be better understood to improve this therapy and provide more individualized treatment according to the patient’s predominant symptoms.

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Reduction of aggressive behaviour following hypothalamic deep brain stimulation: Involvement of 5-HT1A and testosterone

Cited by 5 publications

References 91 publications

Vim-PSA Double-Target DBS for the Treatment of Holmes Tremor Secondary to Brainstem Hemorrhage: A Case Report

Vim-PSA Double-Target DBS for the Treatment of Holmes Tremor Secondary to Brainstem Hemorrhage: A Case Report

Immunomodulatory and endocrine effects of deep brain stimulation and spinal cord stimulation – A systematic review

Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders

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