The catalytic asymmetric
synthesis of α,α-difluoromethylated tertiary alcohols
is described, using an asymmetric dihydroxylation reaction. This protocol
using either the AD-mix-α or AD-mix-β allowed an easy
access to these valuable fluorinated chiral building blocks, which
have been obtained with excellent yields and er. In addition, the
reaction was extended to the α-fluoromethylated analogues.