Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Harach, Taoufiq; Marungruang, Nittaya; Duthilleul, N.; Cheatham, V.; Coy, K. D. Mc; Frisoni, Giovanni B.; Neher, Jonas J.; Fåk, Frida; Jucker, Mathias; Lasser, Theo; Bolmont, Tristan

doi:10.1038/srep41802

Cited by 613 publications

(601 citation statements)

References 47 publications

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“…A small number of studies to date have demonstrated different gut microbial populations in both human and animal models of neurodegenerative disease. Preliminary observations in the APP/PS1 mouse model of Alzheimer’s disease (AD) indicate that these animals harbor decreased Allobaculum and Akkermansia , with an increase in Rikenellaceae compared to wild-type controls (Harach et al, 2015). Concurrently, individuals afflicted with Parkinson’s disease (PD) display significantly different fecal and mucosal microbial populations (Hasegawa et al, 2015; Keshavarzian et al, 2015; Scheperjans et al, 2015).…”

Section: Neurodegeneration and The Microbiome In Old Agementioning

confidence: 99%

The Central Nervous System and the Gut Microbiome

Sharon

Sampson

Geschwind

et al. 2016

Cell

1,035

765

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Summary Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals. While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data suggests communication between the gut and the brain in anxiety, depression, cognition and autism spectrum disorder (ASD). The development of a healthy, functional brain depends on key pre- and post-natal events that integrate environmental cues, such as molecular signals from the gut. These cues largely originate from the microbiome, the consortium of symbiotic bacteria that reside within all animals. Research over the past few years reveals that the gut microbiome plays a role in basic neurogenerative processes such as the formation of the blood-brain-barrier, myelination, neurogenesis, and microglia maturation, and also modulates many aspects of animal behavior. Herein, we discuss the biological intersection of neurodevelopment and the microbiome, and explore the hypothesis that gut bacteria are integral contributors to development and function of the nervous system, and the balance between mental health and disease.

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Section: Neurodegeneration and The Microbiome In Old Agementioning

confidence: 99%

The Central Nervous System and the Gut Microbiome

Sharon

Sampson

Geschwind

et al. 2016

Cell

1,035

765

View full text Add to dashboard Cite

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“…In a mouse model of AD, antibiotic treatment decreases Aβ plaque deposition (Minter et al, 2016) and germ‐free APP transgenic mice have a drastic reduction in cerebral Aβ amyloid pathology (Harach et al, 2017). Poor dental status has been linked to AD or early signs of AD (Gatz et al, 2006).…”

Section: Systems Level Events In Aging and Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.

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“…The microbiome may play a role in the formation of beta-amyloid plaques in the mouse brain during AD development. 336 Germ-free AD transgenic mice have significantly lower levels of beta-amyloid in their brains than conventionally raised transgenic mice. Moreover, AD transgenic mice have a significantly different microbiome than that of wild-type mice and, at the phylum level, Firmicutes and Bacteroidetes levels were significantly altered, whereas at the genus level, Allobaculum and Akkermansia levels were lowered, while unclassified Rikenellaceae and S24-7 genera levels increased.…”

Section: Neurodegenerationmentioning

confidence: 99%

“…Furthermore, fecal transplants from transgenic mice were found to induce significant upregulation of beta-amyloid production in the brains of the germ-free AD transgenic mice. 336 Ischemic stroke. In three separate mouse models of microbiota disruption, the microbiome was shown to impact the outcome of ischemic stroke.…”

Section: Neurodegenerationmentioning

confidence: 99%

Exploring the microbiome in health and disease

Scotti

Boué

Sasso

et al. 2017

Toxicology Research and Application

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The analysis of human microbiome is an exciting and rapidly expanding field of research. In the past decade, the biological relevance of the microbiome for human health has become evident. Microbiome comprises a complex collection of microorganisms, with their genes and metabolites, colonizing different body niches. It is now well known that the microbiome interacts with its host, assisting in the bioconversion of nutrients and detoxification, supporting immunity, protecting against pathogenic microbes, and maintaining health. Remarkable new findings showed that our microbiome not only primarily affects the health and function of the gastrointestinal tract but also has a strong influence on general body health through its close interaction with the nervous system and the lung. Therefore, a perfect and sensitive balanced interaction of microbes with the host is required for a healthy body. In fact, growing evidence suggests that the dynamics and function of the indigenous microbiota can be influenced by many factors, including genetics, diet, age, and toxicological agents like cigarette smoke, environmental contaminants, and drugs. The disruption of this balance, that is called dysbiosis, is associated with a plethora of diseases, including metabolic diseases, inflammatory bowel disease, chronic obstructive pulmonary disease, periodontitis, skin diseases, and neurological disorders. The importance of the host microbiome for the human health has also led to the emergence of novel therapeutic approaches focused on the intentional manipulation of the microbiota, either by restoring missing functions or eliminating harmful roles. In the present review, we outline recent studies devoted to elucidate not only the role of microbiome in health conditions and the possible link with various types of diseases but also the influence of various toxicological factors on the microbial composition and function.

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Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Cited by 613 publications

References 47 publications

The Central Nervous System and the Gut Microbiome

The Central Nervous System and the Gut Microbiome

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Exploring the microbiome in health and disease

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