Reduction of 5α-Cholestan-3-one with Water as a Hydrogen Donor in the Presence of Precipitated Metals

Abstract

Reduction of 5a-cholestan-3-one with various precipitated metals using water as a hydrogen donor was investigated. Precipitated cobalt in I-BuOH and nickel in dioxane afforded 5a-cholestan-3a-ol favorably. Some multi-component precipitated metals were found to show high activity.On a examine la reduction de la 5a-cholestanone-3 par divers mttaux pricipites et utilisant de I'eau comme donneur d'hydrogene. Du cobalt prtcipite dans le f-BuOH et du nickel dans la dioxanne menent favorablement au 5a-cholestanol-3a. On a trouvk que quelques metaux pricipites contenant plusieurs composants possedent une grande activite.[Traduit par le journal]Can. J. Chem., 51,3923 (1973)

Investigation on the Favorable Formation of 5α-Cholestan-3α-ol and 5-Cholesten-3α-ol by Catalytic Hydrogenation

“…Preparation of Precipitated Nickel (1,29) A warmed aqueous solution of nickel chloride (4.04 g of NiCI2.6H2O in 10 ml of water) (ca. 80 "C) was added to hot zinc dust mud (10 g of zinc powder and 3 ml of water) at once with vigorous shaking.…”

“…Previously we reported a study on the stereochemistry of the reduction of 5a-cholestan-3-one with water as a hydrogen donor in the presence of precipitated metals (1).…”