Reduction in Stroke With Gemfibrozil in Men With Coronary Heart Disease and Low HDL Cholesterol

Rubins, Hanna Bloomfield; Davenport, John; Babikian, Viken L.; Brass, Lawrence M.; Collins, Dorothea; Wexler, Laura; Wagner, Stephen; Papademetriou, Vasilios; Rutan, Gale H.; Robins, Sander J.

doi:10.1161/01.cir.103.23.2828

Cited by 235 publications

(101 citation statements)

References 39 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It occurs naturally in a trans-or cis-isoform [7][8][9] . Resveratrol has been reported to have several biologic effects such as a potent antioxidative effect via prevention of lipid peroxidation [10,11] , anti-platelet activity [12] , an estrogenic activity [13] , and anti-inflammatory activity attributed to cyclooxgenase inhibition [6,14] . Previously, it was suggested that resveratrol stimulated nitric oxide production in endothelial cells, has a vasodilatory effect on blood vessels [15] , and improves the energy metabolism system after spinal cord trauma [16] .…”

Section: Introductionmentioning

confidence: 99%

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Gedik¹,

Gırgın²,

Öztürk³

et al. 2008

WJG

View full text Add to dashboard Cite

AIM:To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreated with resveratrol (10 µmol/L, iv). Liver tissues were obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratroltreated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusionrelated liver injury.

show abstract

Section: Introductionmentioning

confidence: 99%

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Gedik¹,

Gırgın²,

Öztürk³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…Large-scale clinical studies in patients with high triglyceride (TG), low HDL-C and normal LDL-C levels have not shown as much positive evidence as that for LDL-C-lowering therapy [8][9][10][11][12] . However, the subanalysis of the ACCORD Lipid Trial 13) revealed that combination therapy with fibrates and statins is effective in patients with high TG and low HDL-C levels; thus, further investigation is warranted.…”

Section: ) Tg-lowering Drugs and Hdl-c-increasing Drugsmentioning

confidence: 99%

Treatment B) Drug Therapy

Teramoto

Sasaki

Ishibashi

et al. 2013

JAT

View full text Add to dashboard Cite

“…These drugs reduce both LDL cholesterol and triglycerides and raise HDL slightly. Gemfibrozil reduced myocardial infarction and stroke among men with coronary artery disease with low HDL and LDL in the Veterans Affairs HDL Intervention Trial (VA-HIT), but recent meta-analysis of fibrates suggested that it has effects on coronary events, but no effect on stroke [56,57].…”

Section: Dyslipidemiamentioning

confidence: 99%

Treatment of Risk Factors to Prevent Stroke

Aoki

Uchino

2011

Neurotherapeutics

View full text Add to dashboard Cite

Much of the decline in stroke incidence and mortality for the past several decades in Western countries has been attributed to better treatment of risk factors. Many epidemiological studies and clinical trials confirmed the importance of managing hypertension. Comparative trials of anti-hypertensive drugs or drug classes have not yielded clear results, but blood pressure variability may play an important role beyond the absolute value of blood pressure. Diabetes therapy remains a conundrum. Although diabetes is clearly a risk factor for ischemic stroke, treatment trials targeting different glycemic goals have not indicated that glucose lowering results in stroke prevention. Trials focused on insulin resistance are ongoing and they may be able to help establish the management of diabetes/impaired glucose tolerance. Evidence for treatment of dyslipidemia has contrasted science to diabetes mellitus. Dyslipidemia has not been strongly or consistently linked to ischemic stroke but the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial showed the impact of statin treatment in stroke prevention. The results of clinical trials investigating dabigatran and rivaroxaban clearly indicate alternative strategies to vitamin K antagonists in stroke prevention for persons with atrial fibrillation. Evidence for stroke prevention by life style modification, treating metabolic syndrome, sleep disordered breathing, lipoprotein (a), hyperhomocysteinemia, and coagulation disorders are also discussed.

show abstract

Reduction in Stroke With Gemfibrozil in Men With Coronary Heart Disease and Low HDL Cholesterol

Abstract: In men with coronary heart disease, low HDL cholesterol, and low LDL cholesterol, gemfibrozil reduces stroke incidence.

Cited by 235 publications

References 39 publications

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Treatment B) Drug Therapy

Treatment of Risk Factors to Prevent Stroke

Contact Info

Product

Resources

About