Reduction in protein absorption on ophthalmic lenses by PEGDA bulk modification of silicone acrylate-based formulation

Abstract

The absorption of protein and formation of biofilms on the surface of ophthalmic lenses is one of the factors that destroy their useful performance by causing severe visual impairment, inflammation, dryness and ultimate eye discomfort. Therefore, eye lenses need to be resilient to protein absorption, which is one of the opacity factors in minimizing protein absorption on the lenses. The purpose of this study was to investigate and reduce sediment biotransformation on the surface of the semi-hardened lens based on acrylate by bulk-free radical polymerization method. In this respect, the effect of poly(ethylene glycol) diacrylate (PEGDA) with two different molecular weights of 200 and 600 g/mol on the surface roughness, protein absorption, and hydrophilicity of the lenses were studied. The surface hardness of the lenses, on shore D scale, was measured using a durometer hardness test. The presence of higher molecular weight of PEGDA hydrophilic polymeric monomers reduced the hardness of the lenses. The effect of introducing PEGDA, with two molecular weights, into lens fabrication formulations was studied with respect to their water content parameters and hydrophilicity. The presence of a crosslinker such as poly(ethylene glycol) diacrylates, at two different molecular weights, increased the water content and hydrophilicity of the produced lenses. Surface roughness is associated with the formation of bio-film and accumulation of microorganisms on the surface. Due to the roughness of the lens surface developed in this research, the lenses containing PEGDA 600 exhibited less roughness compared to that of PEGDA 200, which could also affect the absorption of protein. Therefore, according to the results of protein absorption test, the PEGDA 600 lenses showed lower protein absorption, which could be due to their high degree of water absorption and hydrophilicity.

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

“…The PEGDA spectrum includes the bands at 2889, 1721, and 1623 cm −1 , which refer to the asymmetric stretch vibration of CH 2 , symmetrical stretching vibrations in acrylates of C=O, and the vibration of the aliphatic double bond C=C, respectively. The bands located at 1110, 960, and 843 cm −1 are related to C–O stretch vibration, out-of-plane vibration of the symmetrical stretching of CH 2 =CH, and symmetric stretch vibration of CH 2 =CH [ 36 , 37 , 38 , 39 ]. The Laponite spectrum has bands at 3436, 1635, 1002, and 656 cm −1 , which are related to intramolecular stretch vibrations of OH from adsorbed H 2 O, OH bending vibrations, Si–O stretch vibrations, and Mg–OH–Mg bending vibration, respectively [ 36 ].…”

“…The bands located at 1110, 960, and 843 cm −1 are related to C–O stretch vibration, out-of-plane vibration of the symmetrical stretching of CH 2 =CH, and symmetric stretch vibration of CH 2 =CH [ 36 , 37 , 38 , 39 ]. The Laponite spectrum has bands at 3436, 1635, 1002, and 656 cm −1 , which are related to intramolecular stretch vibrations of OH from adsorbed H 2 O, OH bending vibrations, Si–O stretch vibrations, and Mg–OH–Mg bending vibration, respectively [ 36 ]. The spectra of the nanocomposite hydrogel (PEGDA + Lap and PEGDA + Lap + IG) show the characteristic bands of PEGDA; however, the clay bands appear reduced and masked by the polymer absorption bands.…”

Fabrication of SiO2/PEGDA Inverse Opal Photonic Crystal with Fluorescence Enhancement Effects

“…The vibrations of –OH groups are found at 1634 cm −1 and 3423 cm −1 [ 27 , 28 ]. The FT-IR spectrum of PEGDA (curve (b)) shows a typical peak of the carbonyl group (C=O) at the wavelength of 1724 cm −1 , whereas the peak at the wavelength of 2921 cm −1 is attributed to the CH 2 group of PEGDA [ 29 ]. The spectrum of PEGDA/SiO 2 (curve (c)) shows all dominant peaks corresponding to both PEGDA and SiO 2.…”

Bio-Inspired Polymer Thin Films with Non-Close-Packed Nanopillars for Enhanced Bactericidal and Antireflective Properties

“…We developed a bio-inspired nanostructure on polymer thin films to achieve dual functionalities for antibacterial and antireflective displays. In the present study, we selected poly­(ethylene glycol) diacrylate (PEGDA) as a model biofriendly antifouling polymer with good flexibility. , Moreover, PEGDA or PEGDA-based co-polymers have been developed as a soft optical waveguide with tailored nanostructures for guiding therapeutic lights under skin or in-tissue monitoring devices. − PEGDA can also be formulated with other acrylate-based polymers to prevent protein fouling for the application of ophthalmic lenses, which may potentially prove beneficial for these applications. We created the NCP-5 structure on PEGDA thin films, named pNCP-5, by the soft mold pattern transfer method (Figure ).…”