Reduction in post-prandial hyperglycemic excursion through α-glucosidase inhibition by β-acetamido carbonyl compounds

New antihyperglycemic, α-glucosidase inhibitory, and cytotoxic derivatives of benzimidazoles

“…The study of antihyperglycemic activity was done according to a method reported earlier 21 . Male Wistar rats weighing between 195 and 215 g were obtained from the National Institute of Nutrition (CPCSEA Reg.…”

Melamine Trisulfonic Acid as a Highly Efficient and Reusable Catalyst for the Synthesis of β‐Acetamido Ketones

“…β-Acetamido ketones are useful building blocks for a number of biologically and pharmaceutically valuable compounds [1][2][3][4][5][6][7] . For example, they are precursors of molecules such as 1,3-amino alcohols [1][2][3] and γ-lactams 4 , as well as biologically attractive compounds such as nikkomycins or neopolyoxins 5,6 .…”

“…For example, they are precursors of molecules such as 1,3-amino alcohols [1][2][3] and γ-lactams 4 , as well as biologically attractive compounds such as nikkomycins or neopolyoxins 5,6 . Moreover, it is reported that β-acetamido ketones can act as aglucosidase inhibitors 7 . The one-pot multi-component condensation of acetophenones with aromatic aldehydes, acetonitrile and acetyl chloride has been used as a most common synthetic route towards β-acetamido ketones.…”

Silica Supported Tungstosilicic Acid as an Efficient and Reusable Catalyst for the One-Pot Synthesis of β-Acetamido Ketones via a Four-Component Condensation Reaction

“…19,20 The β-acetamido carbonyl compounds, in that their skeletons exist in a number of valuable biologically or pharmacologically active compounds, 21,22 has gained considerable attention in organic synthesis, owing to their importance as versatile intermediates for preparation of β-amino acids, 23 or 1,3-amino alcohols 24 as well as for the synthesis of various antibiotics such as nikkomycins or neopolyoxines 25 and potent molecules in α-glucosidase inhibitory activity. 26 β-Acetamido ketones were usually prepared through Michael addition to α,β-unsaturated ketones, 27 acylation of β-aminoketones, 28 or photoisomerisation of phthalimides.…”