Reduction in population exposure to PM 2.5 and cancer risk due to PM 2.5 -bound PAHs exposure in Beijing, China during the APEC meeting

Xie, Yangyang; Zhao, Bin; Zhao, Yiyang; Luo, Qinzi; Wang, Yafei; Bai, Shunhua

doi:10.1016/j.envpol.2017.02.059

Cited by 36 publications

(15 citation statements)

References 36 publications

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“…ILCR model was used to quantitatively assess the potential cancer risk of the exposure to PM 2.5 -bound PAHs by inhalation pathway in the following three age groups: children (1-11), teenagers (12)(13)(14)(15)(16)(17), and adults ). The ILCR model for human inhalation is expressed as follows [29]:…”

Section: Health Risk Assessmentmentioning

confidence: 99%

PM2.5-Bound Polycyclic Aromatic Hydrocarbons: Sources and Health Risk during Non-Heating and Heating Periods (Tangshan, China)

Fang

Zhang

Hao

et al. 2020

IJERPH

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Exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to adverse health risks. To understand the potential sources and carcinogenic risks of PAHs in Tangshan, 40 PM2.5 samples were collected for analysis of eighteen PM2.5-bound PAHs during non-heating period and heating period. The results display a significant variation. The median concentration of ∑18PAHs during the heating period (282 ng/m3) was higher than during the non-heating period (185 ng/m3). Especially, the median concentration of Benzopyrene (BaP) during the heating period (61.6 ng/m3) was 16.9-fold that during the non-heating period (3.64 ng/m3). It exceeded BaP annual average limit of China (1 ng/m3). Diagnostic ratios (DRs) and principal component analysis (PCA) both indicated that vehicle emissions and coal and biomass combustion were the dominant contributors of PAHs pollution in Tangshan. The incremental lifetime cancer risk (ILCR) of three age groups (children, teenagers, and adults) ranged from 2.56 × 10−6 to 5.26 × 10−5 during the entire sampling periods. The 95% risk values of adults exceeded 10−4 during the heating periods, indicating a potential health risk from PAHs.

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Section: Health Risk Assessmentmentioning

confidence: 99%

PM2.5-Bound Polycyclic Aromatic Hydrocarbons: Sources and Health Risk during Non-Heating and Heating Periods (Tangshan, China)

Fang

Zhang

Hao

et al. 2020

IJERPH

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“…Reduced cancer risks were also found for the periods with mega-events, such as the APEC meeting (Xie et al, 2017). It should be noted that uncertainties are inherent in cancer risk assessment, as a lack of knowledge about the factors affecting exposure or toxicity assessment (Hong et al, 2016).…”

Section: Reduced Health Risks Of Pahs and Source Allocationmentioning

confidence: 92%

Substantial reductions in ambient PAHs pollution and lives saved as a co-benefit of effective long-term PM2.5 pollution controls

Kong

Yan

Zheng

et al. 2018

Environment International

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Under great efforts in fighting against serious haze problem of China since 2013, decreasing of air pollutants especially for fine particles (PM) has been revealed for several key regions. This study tried to answer whether the reduction of PM-bound polycyclic aromatic hydrocarbons (PAHs) was coincident with PM because of long-term pollution control measures (PCM), and to assess source-oriented health risks associated with inhalation exposure to PAHs. Field measurements were carried out before and after the publishing of local air pollution protection plan for Nanjing, a mega-city in east China. Results indicated that the air quality was substantially improving, with a significant reduction in annual average PM by 34%, and moreover, PM-bound PAHs significantly reduced by 63% (p < 0.001). The remarkable reduction was mainly attributable to the change of emission sources, compared to the influence of atmospheric circulation patterns, surface meteorological conditions, and atmospheric chemical reaction. Four PAHs sources including coal combustion (CC), petroleum and oil burning (PO), wood burning (WB) and vehicle emission (VE) were identified. On an annual basis, contributions to ambient PM-PAHs from WB, PO, CC and VE sources in the period before the action of control measures were 2.26, 2.20, 1.96 and 5.62 ng m, respectively. They reduced to 1.09, 0.37, 1.31 and 1.77 ng m for the four source types, with the reduction percentages as 51, 83, 33 and 68%, respectively. The estimated reduction in lifetime lung cancer risk was around 61%. The study that firstly assessed the health effects of PAHs reduction as a co-benefit raised by air PCM sustained for a long period is believed to be applicable and referential for other mega-cities around the world for assessing the benefits of PCM.

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“…Previous epidemiological studies have indicated that ambient PM2.5 is carcinogenic (30), and may increase the morbidity and mortality rates associated with lung cancer (31,32), and PM2.5 has been suggested to decrease the survival time of patients with lung cancer (33). A short-term decrease in PM2.5 exposure has been demonstrated to decrease the population risk of lung cancer (34).…”

Section: Pm25-induced Pathogenesis Varies In Lung Cancermentioning

confidence: 99%

Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases (Review)

2018

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Previous research has identified that air pollution is associated with various respiratory diseases, but few studies have investigated the function served by particulate matter 2.5 (PM2.5) in these diseases. PM2.5 is known to cause epigenetic and microenvironmental alterations in lung cancer, including tumor-associated signaling pathway activation mediated by microRNA dysregulation, DNA methylation, and increased levels of cytokines and inflammatory cells. Autophagy and apoptosis of tumor cells may also be detected in lung cancer associated with PM2.5 exposure. A number of mechanisms are involved in triggering and aggravating asthma and COPD, including PM2.5-induced cytokine release and oxidative stress. The present review is an overview of the underlying molecular mechanisms of PM2.5-induced pathogenesis in lung cancer and chronic airway inflammatory diseases.

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Reduction in population exposure to PM 2.5 and cancer risk due to PM 2.5 -bound PAHs exposure in Beijing, China during the APEC meeting

Cited by 36 publications

References 36 publications

PM2.5-Bound Polycyclic Aromatic Hydrocarbons: Sources and Health Risk during Non-Heating and Heating Periods (Tangshan, China)

PM2.5-Bound Polycyclic Aromatic Hydrocarbons: Sources and Health Risk during Non-Heating and Heating Periods (Tangshan, China)

Substantial reductions in ambient PAHs pollution and lives saved as a co-benefit of effective long-term PM2.5 pollution controls

Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases (Review)

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