Reduction in orofacial clefts following folic acid fortification of the U.S. grain supply

Yazdy, Mahsa M.; Honein, Margaret A.; Xing, Jian

doi:10.1002/bdra.20319

Cited by 78 publications

(71 citation statements)

References 54 publications

(59 reference statements)

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“…The follow--up observations also indicate that folate supplementation reduces the occurrence of heart defects, urinary tract defects, limb defects, cleft lip and palate and preeclampsia [3,4,[13][14][15].…”

Section: Folate Supplementationmentioning

confidence: 82%

Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines

Bomba‐Opoń¹,

Hirnle²,

Kalinka³

et al. 2017

Ginekol Pol

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Section: Folate Supplementationmentioning

confidence: 82%

Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines

Bomba‐Opoń¹,

Hirnle²,

Kalinka³

et al. 2017

Ginekol Pol

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“…35,36 In addition, a recent review of US birth certificates also showed a decrease in the prevalence rates for orofacial clefts after folic acid fortification. 37 Prevention programs have been developed to reduce the recurrence of neural tube defects by targeting families with an affected child. 38,39 Collection of family history reports among these families provides an opportunity to target additional relatives who might benefit from directed interventions to reduce the occurrence of these defects.…”

Section: Effective Interventions For Preventionmentioning

confidence: 99%

Utility of Family History Reports of Major Birth Defects as a Public Health Strategy

Romitti

2007

Pediatrics

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A major birth defect is an abnormality that can affect the structure or function of an organ. In the United States, major birth defects are the leading cause of infant mortality and contribute substantially to childhood disability and morbidity. Globally, these conditions lead to the death of millions of infants and children annually. Patients with 1 or more affected family members may be at increased risk for having a child with a major birth defect; thus, accurate knowledge of these conditions among family members of their patients gives the clinician the ability to provide improved risk assessment and reproductive planning. Such knowledge can also serve as motivation for patients to adhere to healthy behaviors such as folic acid use or smoking cessation. To evaluate the utility of collecting family history reports of major birth defects as a public health strategy, 6 key criteria were examined by reviewing the relevant published literature. Overall, the review showed that major birth defects satisfied several of the criteria. Additional research is needed, however, regarding the awareness of parent reports of the occurrence of these conditions among relatives and how knowledge of birth defect diagnoses and related risk factors are transmitted among relatives. Such research needs to encompass not only immediate family members but also other first-degree and second-degree relatives. In summary, routine collection of family history reports of birth defects in pediatric practice holds promise as a public health strategy to reduce the burden of morbidity, mortality, and disability associated with major birth defects. 2 To date, gene discovery using such information has accounted for a small proportion of the total burden of a particular disease (eg, BRCA1 mutations for breast cancer prevention). 3 Less well understood is the contribution of a positive family history as a predictor of common chronic diseases that encompass both genetic and partial genetic origins (ie, multifactorial conditions). 4 For the pediatric patient, birth defects exemplify such multifactorial conditions. Birth defects can be grouped into 2 broad categories: major and minor defects. A major defect is an abnormality of an organ structure or function that results in physical disability, mental disability, or death, 5 whereas a minor defect does not produce significant health consequences. 6 Both major and minor defects can occur as isolated entities, affecting 1 organ system, or as multiple defects, affecting 1 or several organ systems. Alone, minor defects are not considered to have significant health consequences, although their presentation with 1 or more major defects can provide clues to an underlying genetic or teratogenic etiology. Conservatively, estimates suggest that a causal gene or teratogen accounts for Ͻ30% of defects that occur. For the remainder, the most likely explanation is a confluence of genetic and teratogenic exposures and, to a lesser degree, factors such as intrauterine constraint and amniotic bands that can l...

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“…Reduction of orofacial clefts risk following mandatory fortification of food was observed by several studies. This inverse association was statistically significant in some of these researches [12,13,14] and insignificant in others [15,16,17].…”

Section: Int J Adv Res 5(3) 2265-2274mentioning

confidence: 87%

Maternal Intake of Folic Acid Supplementation and Non- syndromic Orofacial Clefts Risk: Systematic Review and Meta Analysis.

Almalki¹,

Alsubhi²,

Alkhoraisy³

et al. 2017

IJAR

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Reduction in orofacial clefts following folic acid fortification of the U.S. grain supply

Cited by 78 publications

References 54 publications

Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines

Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines

Utility of Family History Reports of Major Birth Defects as a Public Health Strategy

Maternal Intake of Folic Acid Supplementation and Non- syndromic Orofacial Clefts Risk: Systematic Review and Meta Analysis.

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