Reduction in olfactory ability in agingMitfmutant mice without neurodegeneration
Fatich Mechmet,
Eiríkur Steingrímsson,
Pétur Henry Petersen
Abstract:Age-related decline occurs in most brain structures and sensory systems. An illustrative case is olfaction, where the olfactory bulb (OB) undergoes deterioration with age, resulting in reduced olfactory ability. Decline in olfaction is also associated with early symptoms of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD). However, the underlying reasons are unclear. The microphthalmia-associated transcription factor (MITF) is expressed in the projection neurons (PNs) … Show more
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