Reduction in Muscle Fiber Force Production, Disruption of Muscle Cell Architecture and Accumulation of Fatty Macrophages in Patients with Chronic Rotator Cuff Tears
Abstract:Objectives:A common pathophysiological change that occurs in torn rotator cuff muscles is atrophy of muscle fibers and an accumulation of intramuscular fat, collectively referred to as "fatty degeneration." For many patients with chronic rotator cuff tears that undergo surgical repair, fatty degeneration is not resolved. The etiology of fatty degeneration has not been characterized in humans, and gaining greater insight into the mechanisms that lead to the development of atrophy and fat accumulation will likel… Show more
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