Reduction in High Rates of Antibiotic-Nonsusceptible Invasive Pneumococcal Disease in Tennessee after Introduction of the Pneumococcal Conjugate Vaccine

Talbot, Thomas R.; Poehling, Katherine A.; Hartert, Tina V.; Arbogast, Patrick G.; Halasa, Natasha; Mitchel, Ed; Schaffner, William; Craig, Allen S.; Edwards, Kathryn M.; Griffin, Marie R.

doi:10.1086/422653

Cited by 127 publications

(78 citation statements)

References 18 publications

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“…The annual incidence of invasive disease caused by S. pneumoniae has decreased signifi cantly in all age groups with the introduction of the 7-valent pneumococcal conjugate vaccine (PCV-7) in 2000 (33). Further, disease caused by resistant S. pneumoniae has also decreased signifi cantly with the introduction of the PCV-7 vaccine, which targeted the resistant serotypes (33,34). Thus, antimicrobial drug resistance to S. pneumoniae seems unlikely to be responsible for the increase in empyema deaths since the introduction of PCV-7.…”

Section: Discussionmentioning

confidence: 99%

Parapneumonic Empyema Deaths during Past Century, Utah

Bender¹,

Ampofo²,

Sheng³

et al. 2009

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

Parapneumonic Empyema Deaths during Past Century, Utah

Bender¹,

Ampofo²,

Sheng³

et al. 2009

Emerg. Infect. Dis.

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“…La vacuna heptavalente ha demostrado ser efectiva para reducir los niveles de resistencia a los antibióticos (50,53,54); un efecto similar se podría esperar en nuestro país debido a que los serotipos contenidos en la vacuna representan el 97,3% de los aislamientos con SDP. Sin embargo, como consecuencia de la vacunación se ha observado en los niños inmunizados una disminución en los serotipos vacunales con un incremento en la colonización por serotipos no contenidos en la vacuna, probablemente debido a un reemplazo de serotipos o al desenmascaramiento de poblaciones minoritarias de S. pneumoniae (50,54).…”

Section: Discussionunclassified

Streptococcus pneumoniae: evolución de los serotipos y los patrones de susceptibilidad antimicrobiana en aislamientos invasores en 11 años de vigilancia en colombia (1994 -2004).

Agudelo¹,

Moreno²,

Sanabria³

et al. 2006

biomedica

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Introducción. Streptococcus pneumoniae es una las principales causas de morbilidad y mortalidad en niños y adultos en el mundo. Objetivo. Realizar un análisis de los datos de la vigilancia por el laboratorio de los aislamientos invasores de S. pneumoniae recuperados entre 1994 y 2004. Materiales y métodos. Se empleó la información de los aislamientos invasores de S. pneumoniae recibidos en el Grupo de Microbiología del Instituto Nacional de Salud durante la vigilancia de meningitis bacteriana aguda e infección respiratoria aguda entre 1994 y 2004. Los aislamientos contaban con datos epidemiológicos, serotipo, patrones de susceptibilidad antimicrobiana y algunos con tipificación molecular. Resultados. Se analizaron los datos de 2.022 aislamientos procedentes de 120 hospitales de diferentes regiones del país, recuperados principalmente de hemocultivos (50,7%) y líquido cefalorraquídeo (42%). Los serotipos más importantes fueron el 14, 6B, 23F, 1, 5, 6A, 19F, 18C y 9V, los cuales corresponden al 83,6% en niños menores de 6 años, al 74,0% en el grupo de 6 a 14 años y al 61,4% en mayores de 14 años. El 29,8% de los aislamientos presentó susceptibilidad disminuida a la penicilina (SDP), 44,3% a trimetoprim-sulfametoxazol, 32,4% a tetraciclina, 8,2% a cloranfenicol, 3,8% a eritromicina; todos fueron sensibles a vancomicina y el 13% fue multirresistente. Se tipificaron 602 aislamientos con SDP, de los cuales 27 (4,5%) se relacionaron con el clon 1-España 23F , 38 (6,3%) con el clon 2-España 6B , 301 (50%) con el 3-España 9V y 75 (12,5%) con el clon 26-Colombia 23F , además, los 138 aislamientos con tipo capsular 5 se relacionaron con el clon 19-Colombia 5 . Conclusiones. Los resultados proporcionan información básica necesaria para el diseño e implementación de estrategias para la prevención de la enfermedad neumocócica en nuestro país.Palabras clave: Streptococcus pneumoniae, infecciones neumocócicas, meningitis, neumonía, resistencia a las drogas.

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“…For example, the introduction of the pneumococcal conjugate vaccines has led to the reduction in resistant Streptococcus pneumoniae not only in the vaccinated population but also in the population as a whole. 61,62 The development of rapid point-of-care diagnostic tools may be of use to reduce clinical uncertainty, to save unnecessary antibiotic treatments, and to select effective antibiotics where resistance has rendered first-line treatment ineffective. 63 The recent discovery of a new antibiotic called teixobactin, with excellent activity against Grampositive pathogens, including drug-resistant strains, represents a hope for the future and an example for new researches.…”

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confidence: 99%

Antimicrobial resistance: a global multifaceted phenomenon

Prestinaci

Pezzotti

Pantosti

2015

Pathogens and Global Health

2,062

1,370

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Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. The first World Health Organization (WHO) Global report on surveillance of AMR, published in April 2014, collected for the first time data from national and international surveillance networks, showing the extent of this phenomenon in many parts of the world and also the presence of large gaps in the existing surveillance. In this review, we focus on antibacterial resistance (ABR), which represents at the moment the major problem, both for the high rates of resistance observed in bacteria that cause common infections and for the complexity of the consequences of ABR. We describe the health and economic impact of ABR, the principal risk factors for its emergence and, in particular, we illustrate the highlights of four antibiotic-resistant pathogens of global concern -Staphylococcus aureus, Klebsiella pneumoniae, non-typhoidal Salmonella and Mycobacterium tuberculosis -for whom we report resistance data worldwide. Measures to control the emergence and the spread of ABR are presented.

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Reduction in High Rates of Antibiotic-Nonsusceptible Invasive Pneumococcal Disease in Tennessee after Introduction of the Pneumococcal Conjugate Vaccine

Abstract: In the 2 years since licensure, widespread PCV vaccination of children has resulted in dramatic declines in the proportion of antibiotic-nonsusceptible isolates in Tennessee. PCV vaccination of children also appears to be a highly effective method for reducing the burden of IPD in adults.

Cited by 127 publications

References 18 publications

Parapneumonic Empyema Deaths during Past Century, Utah

Parapneumonic Empyema Deaths during Past Century, Utah

Streptococcus pneumoniae: evolución de los serotipos y los patrones de susceptibilidad antimicrobiana en aislamientos invasores en 11 años de vigilancia en colombia (1994 -2004).

Antimicrobial resistance: a global multifaceted phenomenon

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