Reduction in delta activity predicted improved negative affect in Major Depressive Disorder

Cheng, Philip; Goldschmied, Jennifer; Casement, Melynda D.; Kim, Hyang Sook; Armitage, Roseanne; Deldin, Patricia J.

doi:10.1016/j.psychres.2015.05.037

Cited by 19 publications

(16 citation statements)

References 16 publications

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“…It is also important to recognize that merely increasing SWS may not be beneficial for treating depression. On the contrary, some preliminary studies have found that the reduction of SWS is associated with modest improvements in depressed mood (Landsness et al, 2011) or negative affect (Cheng et al, 2015). From the perspective of ENCORE-D, the dysfunctional renormalization of synaptic strength (i.e., reduced downscaling in depressogenic or facilitated downscaling in nondepressogenic areas) may constitute one characteristic that maintains depressive information processing.…”

Section: Discussion Of Encoding Consolidation and Renormalizatiomentioning

confidence: 99%

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Rantamäki

Kohtala

2020

Pharmacol Rev

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Brain and Mind Doctoral Program (S.K.), the Orion Research Foundation (S.K.), and the Emil Aaltonen foundation (S.K.). T.R. and S.K. are listed as coinventors on a patent application, wherein new tools enabling the development of rapid-acting antidepressants and the efficacy monitors thereof are disclosed based on the basic principles of ENCORE-D. T.R. and S.K. have assigned their patent rights to the University of Helsinki but will share a percentage of any royalties that may be received by the University of Helsinki.

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Section: Discussion Of Encoding Consolidation and Renormalizatiomentioning

confidence: 99%

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Rantamäki

Kohtala

2020

Pharmacol Rev

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“…These results suggest that memory processing during sleep can influence emotional well-being. Disruption of SWS has been shown to improve depressive symptoms, with a reduction in slow wave activity correlated with improvement in negative affect (Cheng et al, 2015; Landsness et al, 2011). As depressed individuals show an exaggerated negativity bias (Gotlib and Joorman, 2010), interruption of negative memory processing may contribute to the beneficial effects of SWS restriction in this population.…”

Section: Discussionmentioning

confidence: 99%

Emotional bias of sleep-dependent processing shifts from negative to positive with aging

Jones

Schultz

Adams

et al. 2016

Neurobiology of Aging

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Age-related memory decline has been proposed to result partially from impairments in memory consolidation over sleep. However, such decline may reflect a shift toward selective processing of positive information with age rather than impaired sleep-related mechanisms. In the current study, young and older adults viewed negative and neutral pictures or positive and neutral pictures and underwent a recognition test after sleep or wake. Subjective emotional reactivity and affect were also measured. Compared to waking, sleep preserved valence ratings and memory for positive but not negative pictures in older adults and negative but not positive pictures in young adults. In older adults, memory for positive pictures was associated with slow wave sleep. Furthermore, slow wave sleep predicted positive affect in older adults but was inversely related to positive affect in young adults. These relationships were strongest for older adults with high memory for positive pictures and young adults with high memory for negative pictures. Collectively, these results indicate preserved but selective sleep-dependent memory processing with healthy aging that may be biased to enhance emotional well-being.

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“…Past reports suggested that patients with CKD tend to have more prominent delta wave activities with worsening renal function due to uremic encephalopathy [ 34 ], resulting in the observed increase in delta power among those with mild frailty in the current study. Finally, depression or anxiety reportedly influences delta power in affected patients [ 35 , 36 ]. Given the increased prevalence of depression or anxiety in patients with ESRD and frequent co-existence of frailty with these disorders [ 37 , 38 ], it is possible that the observed EEG patterns can be attributed to the discrepancy in the prevalence of these disorders between patients with different frail severity.…”

Section: Discussionmentioning

confidence: 99%

Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

et al. 2017

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BackgroundFrailty is prevalent among patients with end-stage renal disease (ESRD) and is associated with an increased risk of cognitive impairment. However, apart from its influence on cognition, it is currently unknown whether frailty affects subtler cerebral function in patients with ESRD.MethodsPatients with ESRD were prospectively enrolled, with clinical features and laboratory data recorded. The severity of frailty among these patients with ESRD was ascertained using the previously validated simple FRAIL scale, and was categorized as none-to-mild and moderate-to-severe frailty. All participants underwent quantitative electroencephalography (EEG), with band powers documented following the generation of the delta to alpha ratio (DAR) and delta/theta to alpha/beta ratio (DTABR). EEG results were then compared between groups of different levels of frailty.ResultsIn this cohort, (mean age: 68.9 ± 10.4 years, 37% male, 3.4 ± 3 years of dialysis), 20, 60, 40, 17, and 6% patients exhibited positivity in the fatigue, resistance, ambulation, illness, and loss-of-body-weight domains, respectively, with 45.7% being none to mildly frail and 54.3% being moderately to severely frail. Those with mild frailty had a significantly higher delta power compared to those with more severe frailty, involving all topographic sites. Patients with ESRD and severe frailty had significantly lower global, left frontal, left temporo-occipital, and right temporo-occipital DAR and DTABR, except in the right frontal area, and tended to have central accentuation of alpha, beta, and theta power, and more homogeneous DTABR and DAR distribution compared to the findings in those with mild frailty.ConclusionsFrailty in patients with ESRD can have subtler neurophysiological influences, presenting as altered EEG findings, which warrant our attention.

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Reduction in delta activity predicted improved negative affect in Major Depressive Disorder

Cited by 19 publications

References 16 publications

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Emotional bias of sleep-dependent processing shifts from negative to positive with aging

Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

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