Reduction Effect of Royal Jelly and Rape Honey Alone and in Combination Against Methicillin-Resistant Staphylococcus aureus (MRSA) Strains

Dinkov, Dinko; Stratev, Deyan; Balkanska, Ralitsa; Sergelidis, Daniel; Vashin, I.

doi:10.4167/jbv.2016.46.1.36

Cited by 4 publications

(5 citation statements)

References 27 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All analysed samples of RJ inhibited the growth of the clinical strain of E. coli better than they inhibited the reference strain. Studies established that RJ possesses antibacterial activity against strains of gram-positive bacteria [9]. Various studies developed the knowledge that the antibacterial activity of RJ depends on biologically active compounds in the composition, such as 10-HDA.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Reports suggest that RJ is a suitable candidate for modelling pharmaceutical products that exhibit antibacterial effects [7]. The antibiotic resistance of bacteria is a critical problem globally.…”

Section: Introductionmentioning

confidence: 99%

“…Royalisin is effective against gram-positive bacteria but not against gram-negative bacteria [8]. The antibacterial properties of RJ are associated with fatty acid 10-HDA [9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lithuanian Royal jelly: quality assessment, biological activity and quantitative determination of trans-10-hydroxy-2-decenoic acid in various solvents

Perminaitė¹,

Marksa²,

Ivanauskas³

et al. 2020

chemija

View full text Add to dashboard Cite

Royal jelly is a bee product with a high commercial interest due to its exceptional biological properties and unique composition. In this study, we evaluated the quality of Lithuanian Royal jelly, including the water content, antioxidant activity, amount of polyphenolic compounds and pH. The results indicated that Lithuanian Royal jelly had the values of pH, water content as well as polyphenols that were comparable to the data already published. In the study, we also evaluated the impact of various solvents on the amount of 10-hydroxy-2-decenoic acid (10-HDA), the main fatty acid, naturally occurring only in Royal jelly and which is the quality marker, in solutions obtaining the amount using the HPLC method. According to solubility tests performed, 10-HDA from Royal jelly is best soluble in ethanol of various concentrations, yet in order to be used for exceptional Royal jelly antibacterial and many other biological properties it was important to increase the solubility in aqueous solutions. Addition of β-cyclodextrin has increased the amount of 10-HDA in solution up to the level of ethanol solutions. The antioxidant and antibacterial tests have demonstrated that Lithuanian Royal jelly exhibits positive effects against free radicals, as well as mostly occurring bacterial strains, such as Esherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus aureus. As the conclusion of this study, we can assume that the quality assessment methods chosen for this study, are significant for standardizing the procedures for further studies.

show abstract

Section: Antibacterial Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lithuanian Royal jelly: quality assessment, biological activity and quantitative determination of trans-10-hydroxy-2-decenoic acid in various solvents

Perminaitė¹,

Marksa²,

Ivanauskas³

et al. 2020

chemija

View full text Add to dashboard Cite

show abstract

“…Initially, each bacterium was grown in NA for 18 h at 37°C. Next, an inoculum was prepared by adjusting the concentration to 0.5 MacFarland units in sterile saline (∼1 × 10 8 CFU/mL) ( Sharafati-Chaleshtori et al, 2010 ; Dinkov et al, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Nanoemulsion and nanoencapsulation of a hydroethanolic extract of Nettle (Urtica dioica) and Wormwood (Artemisia absinthium): comparison of antibacterial and anticancer activity

Rahmani,

Karimi,

Saffari

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

Introduction: Nanoemulsion and nanoencapsulation are attractive novel methods that can be used for incorporating active plant extracts in food preparations and pharmaceutical formulations. In the current study, we aimed to investigate the anticancer and antibacterial effects of hydroethanolic extracts of Nettle (NE), Wormwood (WE), and the combination of the two plants (CNWE), as well as their nanoemulsion forms (NN, NW, CNNW) and nanoencapsulation forms (CN, CW, and CCNW).Methods: The morphology and structure of the nanoemulsion and nanoencapsulation preparations were assessed utilizing dynamic light scattering (DLS) along with transmission electron microscopy (TEM). The antibacterial activity of the prepared formulations were assessed by determining minimum inhibitory concentration (MIC), zone of inhibition diameter, minimum bactericidal concentration (MBC), along with biofilm growth inhibition against Salmonaella typhimurium and Klebsiella. pneumoniae. The anticancer activity was evaluated via a MTT assay in the colon cancer cell line (HCT116).Results: The nanoemulsion and nanoencapsulation particle size varied between 10 and 50 nm and 60 and 110 nm, respectively. The MIC values were between 11.25 and 95 µg/mL along with MBC values between 11.25 and 190 µg/mL. The highest inhibition of biofilm formation was observed with CCNW against K. pneumoniae (∼78.5%) and S. typhimurium (∼73%). In descending order, the inhibition of biofilm formation was CCNW > CW > CN > CNNW > NN > NW > CNWE > NE > WE against the tested bacteria. The IC50 values for NE, WE, CNWE, NN, NW, CNNW, CN, CW, and CCNW were determined as 250, 170, 560, 380, 312, 370, 250, 420, and 700 µg/mL, respectively. Exposure to a high concentration of NW resulted in a significantly lower HCT116 viability compared to other groups. Taken together, CNNW, and CCNW showed the highest antibacterial and anticancer activitiy.Discussion: Nanoemulsion and nanoencapsulation were effective ways to increase the antibacterial and anticancer activity of the extracts and could be used in the food and pharmaceutical industries.

show abstract

“…In an interesting study comparing RJ and 2% chlorhexidine solution, RJ was reported to have serious potential for dental procedures as a disinfectant [70]. Dinkov et al [71] stated significant inhibitory activity against methicillin-resistant Staphylocuccus aureus, which is a problem for hospitalacquired infections. Similar results were found against Aeromonas hydrophila [72].…”

Section: Antimicrobial Effectsmentioning

confidence: 99%

Royal jelly: a natural therapeutic?

2019

View full text Add to dashboard Cite

Royal jelly is a secretion of honeybees that is actually for feeding of bee larvae. It contains many bioactive substances such as jelleins, royalisin, major royal jelly proteins and 10-hydroxy-2-decenoic acid. Recently, many studies were published investigating activities of royal jelly. In overall, royal jelly found to have antioxidant, neurotrophic, antidiabetic, hypocholesterolemic, regulatory on blood pressure, antimicrobial, immunomodulatory, anti-tumor and tissue-protective effects. These activities are strongly related to each other and cannot be evaluated separately. Researchers claim that royal jelly can be an excellent therapeutic agent (or an additional agent), especially in treatments of cancer and metabolic syndrome. However, there are huge gaps due to limited number of in vivo studies and there are standardization issues both for usage and investigations. Furthermore, wide variability of contents in royal jelly due to geographic locations, climate, etc also causes a problem in choice of exact royal jelly. Currently it seems to be safe and effective nutritious agent for healthy people, but it is hard to gain an overall perspective in usage as a therapeutic, since there is a necessity of wider studies with more different types of royal jelly. Sığ et al. / Royal jelly 334 ORTADOGU TIP DERG 2019; 11(3): 333-341 ÖZ Arı sütü aslen arı larvalarının beslenmesi için bal arıları tarafından üretilen bir sekresyondur. Jelleinler, royalizin, ana arı sütü proteinleri ve 10-hidroksi-2-desenoik asit gibi çok sayıda biyoaktif madde içermektedir. Son yıllarda arı sütü konusunda çok sayıda makale yayımlanmıştır. Genel olarak, arı sütü, antioksidan, nörotropik, antidiyabetik, hipokolesterolemik, kan basıncı düzenleyici, antimikrobiyal, immünomodülatör, anti-tümör ve doku koruyucu etkileri göstermektedir. Bu etkiler aslen bir bütündür ve mekanizmaları ayrı ayrı değerlendirmek mümkün değildir. Araştırmacılar, özellikle kanser ve metabolik sendrom tedavisinde iyi bir tedavi ajanı (veya tedaviye ek bir ajan) olabileceğini iddia etmektedir. Öte yandan, in vivo çalışmaların sayısı son derece sınırlıdır ve hem araştırma hem kullanım alanlarında standardizasyon sorunu vardır. Ayrıca, coğrafi konum, iklim gibi koşullara bağlı olarak arı sütü içeriğinin ciddi farklılıklar göstermesi, arı sütünün seçiminde sorunlar yaratmaktadır. Şu an için, sağlıklı insanlarda güvenli ve etkin bir besleyici gıda olarak gözükmekte, fakat terapötik kullanımı konusunda genel bir görüş elde etmek mümkün gözükmemektedir. Farklı türlerde arı sütleri üzerinde daha geniş çaplı araştırmalar yapılmalıdır.Anahtar kelimeler: arı sütü, apiterapi, arı ürünleri, biyofarmasötik ajanlar, geleneksel ve tamamlayıcı tıp

show abstract

Reduction Effect of Royal Jelly and Rape Honey Alone and in Combination Against Methicillin-Resistant Staphylococcus aureus (MRSA) Strains

Cited by 4 publications

References 27 publications

Lithuanian Royal jelly: quality assessment, biological activity and quantitative determination of trans-10-hydroxy-2-decenoic acid in various solvents

Lithuanian Royal jelly: quality assessment, biological activity and quantitative determination of trans-10-hydroxy-2-decenoic acid in various solvents

Nanoemulsion and nanoencapsulation of a hydroethanolic extract of Nettle (Urtica dioica) and Wormwood (Artemisia absinthium): comparison of antibacterial and anticancer activity

Royal jelly: a natural therapeutic?

Contact Info

Product

Resources

About