Reduction by Δ⁹‐ tetrahydrocannabinol in the blood pressure of hypertensive rats bearing regenerated adrenal glands

Role of lipids and lipid signaling in the development of cannabinoid tolerance

“…Tolerance development has been documented in numerous animal species, including pigeons, rodents, dogs, monkeys and rabbits (McMillan et al, 1971;Kaymakcalan, 1973;Wikler, 1976;Compton et al, 1990) and to behavioral effects that include antinociception (Martin, 1985), anticonvulsant activity (Colasanti et al, 1982), catalepsy (Pertwee, 1974), depression of locomotor activity (Karler et al, 1984), hypothermia (Thompson et al, 1974), hypotension (Birmingham, 1973), corticosteroid release (Miczek and Dihit, 1980), ataxia in dogs (Martin et al, 1976) and schedule-controlled behavior (McMillan et al, 1970). The fact that tolerance develops to multiple behavioral effects raises the question as to whether a single mechanism accounts for all tolerance (Fan et al, 1994).…”

Blood pressure regulation by endocannabinoids and their receptors

“…The intriguing possibility of using cannabinoid ligands as antihypertensive agents was first considered more than 30 years ago (Archer, 1974;Adams et al, 1977;Birmingham, 1973;Crawford and Merritt, 1979;Varma and Goldbaum, 1975;Zaugg and Kyncl, 1983). However, initial enthusiasm was tempered by the inability to separate the neurobehavioral and cardiovascular effects of cannabinergic ligands and also by a report of the development of rapid tolerance to the hypotensive and bradycardic effects of THC (Adams et al, 1976).…”

TOLERANCE TO THE CARDIOVASCULAR EFFECTS OF Δ9‐TETRAHYDROCANNABINOL IN THE RAT

“…Also, Nahas, Schwartz, Adamec & Manger (1973) presented evidence for the rapid development of tolerance to the hypotensive effects of A9-THC in spontaneously hypertensive rats. However, studies by Birmingham (1973), Williams, Ng, Lamprecht, Roth & Kopin (1973) and Lewis, Brown & Forney (1974), failed to demonstrate tolerance to the hypotensive actions of A9-THC in either hypertensive (spontaneous or adrenal-regeneration) or normotensive animals following pretreatment periods ranging from 7-14 days.…”