Reduction by Paroxetine of Suicidal Behavior in Patients With Repeated Suicide Attempts But Not Major Depression

Verkes, Robbert J.; Mast, Rose C. van der; Hengeveld, Michiel W.; Tuyl, Jolien P.; Zwinderman, Aeilko H.; Kempen, G.M.J. Van

doi:10.1176/ajp.155.4.543

Cited by 159 publications

(73 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, Verkes et al found a significant decrease in suicide attempts in patients without major depression who were treated with paroxetine. 41 These findings, along with our results, suggest that screening and subsequently treating targeted males for depressive symptoms may decrease their aggressive behavior.…”

Section: Discussionsupporting

confidence: 71%

The Relationship among Depressive and Alcoholic Symptoms and Aggressive Behavior in Adult Male Emergency Department Patients

Bacaner

Kinney

Biros

et al. 2002

Academic Emergency Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 71%

The Relationship among Depressive and Alcoholic Symptoms and Aggressive Behavior in Adult Male Emergency Department Patients

Bacaner

Kinney

Biros

et al. 2002

Academic Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…On the one hand, psychosocial interventions that are successful in treating depression and hopelessness among suicidal individuals have shown minimal efficacy in reducing rates of attempted suicide (Lerner and Clum, 1990;Rotheram-Borus et al, 1996). On the other hand, interventions that reduce the frequency and severity of attempted suicide in adult samples generally are not effective in ameliorating depressive affect (Linehan et al, 1991;Verkes et al, 1998). Together, these findings suggest that the change mechanisms required for the reduction of suicidal behavior might differ from those of treating depression, and that one cannot assume that suicidal risk decreases in tandem with depressive affect.…”

Section: Discussionmentioning

confidence: 97%

Multisystemic Therapy Effects on Attempted Suicide by Youths Presenting Psychiatric Emergencies

Huey

Henggeler

Rowland

et al. 2004

Journal of the American Academy of Child & Adolescent Psych

276

187

View full text Add to dashboard Cite

Objective: To evaluate the efficacy of multisystemic therapy (MST) in reducing attempted suicide among predominantly African American youths referred for emergency psychiatric hospitalization. Method: Youths presenting psychiatric emergencies were randomly assigned to MST or hospitalization. Indices of attempted suicide, suicidal ideation, depressive affect, and parental control were assessed before treatment, at 4 months after recruitment, and at the 1-year posttreatment follow-up. Results: Based on youth report, MST was significantly more effective than emergency hospitalization at decreasing rates of attempted suicide at 1-year follow-up; also, the rate of symptom reduction over time was greater for youths receiving MST. Also, treatment differences in patterns of change in attempted suicide (caregiver report) varied as a function of ethnicity, gender, and age. Moreover, treatment effects were found for caregiver-rated parental control but not for youth depressive affect, hopelessness, or suicidal ideation. Conclusions: Results generally support MST's effectiveness at reducing attempted suicide in psychiatrically disturbed youngsters, whereas the effects of hospitalization varied based on informant and youth demographic characteristics.

show abstract

“…Several recent controlled trials have reported that specific serotonin reuptake inhibitors (SSRI) are effective at reducing the recurrence of suicide attempts and decreasing impulsive aggression traits in subjects with and without personality disorders. 12,13 These main effects were independent of an antidepressant effect.…”

mentioning

confidence: 82%

Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene

et al. 2001

View full text Add to dashboard Cite

There is compelling evidence that serotonin system dysfunction is associated with certain behavioral disorders, such as suicidal behavior and impulsive aggression. A functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was recently identified and the presence of the short allele found to be associated with a lower level of expression of the gene, lower levels of 5-HT uptake, suicidal behavior and anxiety-related traits. We genotyped 51 West European Caucasians who had made violent suicide attempts and 139 controls of the same ethnic origin, with no history of suicidal behavior. The frequencies of the S allele and the SS genotype were significantly higher in the violent suicide attempters than in the controls. The odds ratio for the SS genotype vs the LL genotype was 3.63 (95% CI (1.27-10.40)). This suggests that a change in expression of the gene encoding the 5-HT transporter may be involved in violent suicidal behavior. Molecular Psychiatry (2001) 6, 338-341. Since the seminal studies by Asberg and collaborators in the mid 1970s, 1 most studies have shown that impulsive aggression and suicidal behavior are correlated with low levels of 5-HT transmission.2 This association is stronger for more severe phenotypes: lethal and/or violent suicidal behavior and violent aggressive behavior.3-5 The magnitude and duration of serotonergic activity is believed to be regulated mainly by the human serotonin transporter (5-HTT), which controls the uptake of serotonin from the synaptic junction.6,7 The human 5-HTT is in a presynaptic location and Lesch et al 7 have demonstrated that it is identical in platelets and in the brain. Conflicting results have been obtained in studies of the platelet 5-HT transporter in individuals with suicidal behavior. Some studies have shown a decrease in the number of 5-HT transporter recognition sites in such individuals, as shown by the radiolabeled ligand-binding technique, and in the amount of 5-HT transporter protein, as shown by 5-HT uptake measurements. 8,9 Despite differences in the results obtained, probably due to differences in the ligands used, studies of radioligand binding in the brainstem of individuals who have committed suicide and in platelets have provided evidence that there is a negative association between serotonin dysfunction and impulsive aggression and violent or suicidal behavior. [8][9][10][11] Coccaro et al 11 studied patients with personality disorders and found a negative correlation between aggression and tritiated paroxetine binding to platelet serotonin transporter sites. Roy 9 recently reported that the affinity of the serotonin uptake protein for serotonin is lower in depressed patients displaying suicidal behavior than in depressed patients who have never attempted suicide and in controls. This lower affinity for serotonin was also found to have predictive value for subsequent suicide attempts and suicides during a 5-year follow-up period.Pharmacological studies have also provided evidence that the serotonin transport...

show abstract

Reduction by Paroxetine of Suicidal Behavior in Patients With Repeated Suicide Attempts But Not Major Depression

Abstract: This study indicates that enhancing serotonergic function with an SSRI may reduce suicidal behavior in a subgroup of patients who have attempted suicide more than once but who do not suffer from major depression.

Cited by 159 publications

References 24 publications

The Relationship among Depressive and Alcoholic Symptoms and Aggressive Behavior in Adult Male Emergency Department Patients

The Relationship among Depressive and Alcoholic Symptoms and Aggressive Behavior in Adult Male Emergency Department Patients

Multisystemic Therapy Effects on Attempted Suicide by Youths Presenting Psychiatric Emergencies

Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene

Contact Info

Product

Resources

About