Reduction- and thermo-sensitive star polypeptide micelles and hydrogels for on-demand drug delivery

Liu, Donglin; Xiao, Changyan; Dong, Chang‐Ming

doi:10.1039/c2cc38343h

Cited by 78 publications

(61 citation statements)

References 38 publications

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“…Hydrogels as drug delivery scaffolds and tissue engineering tools have traditionally been constructed with hydrophilic polymers of high molecular weight, cross-linked through either covalent bonds or physically associating groups. 1–10 One example of these materials is synthetic polypeptides prepared by N-carboxy anhydride (NCA) polymerization, 11 yielding low dispersity, high molecular weight polypeptides, 12 which has led to hierarchical self-assembled nanoscale structures with tunable properties 13 and a wide range of biological applications. 14,15 …”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive and Mechanical Properties of Poly(l-proline) Gels

2016

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Gelation of the left helical N-substituted homopolypeptide poly(l-proline) (PLP) in water was explored, employing rheological and small-angle scattering studies at different temperatures and concentrations in order to investigate the network structure and its mechanical properties. Stiff gels were obtained at 10 wt % or higher at 5 °C, the first time gelation has been observed for homopolypeptides. The secondary structure and helical rigidity of PLP has large structural similarities to gelatin but as gels the two materials show contrasting trends with temperature. With increasing temperature in D2O, the network stiffens, with broad scattering features of similar correlation length for all concentrations and molar masses of PLP. A thermoresponsive transition was also achieved between 5 and 35 °C, with moduli at 35 °C higher than gelatin at 5 °C. The brittle gels could tolerate strains of 1% before yielding with a frequency-independent modulus over the observed range, similar to natural proline-rich proteins, suggesting the potential for thermoresponsive or biomaterial-based applications.

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive and Mechanical Properties of Poly(l-proline) Gels

2016

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“…Diethylene glycol-L-glutamate was used for preparation of star polypeptides as well [46]. Tetra(amine) compound with a disulfide bond was used as initiator core.…”

Section: Polypeptide-based Hybrid Materials With Various Molecular Armentioning

confidence: 99%

Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures

Pahovnik

Hadjichristidis

2015

Anionic Polymerization

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Different synthetic approaches utilizing ring-opening polymerization of N-carboxyanhydrides for preparation of polypeptide and polypeptide-based hybrid materials with various molecular architectures are described. An overview of polymerization mechanisms using conventional (various amines) as well as some recently developed initiators (hexamethyldisilazane, N-heterocyclic persistent carbenes, etc.) is presented, and their benefits and drawbacks for preparation of polypeptides with well-defined chain lengths and chain-end functionality are discussed. Recent examples from literature are used to illustrate different possibilities for synthesis of pure polypeptide materials with different molecular architectures bearing various functional groups, which are introduced either by modification of amino acids, before they are transformed into corresponding Ncarboxyanhydrides, or by post-polymerization modifications using protective groups and/or orthogonal functional groups. Different approaches for preparation of polypeptide-based hybrid materials are discussed as well using examples from recent literature. Syntheses of simple block copolymers or copolymers with more complex molecular architectures (graft and star copolymers) as well as modifications of nanoparticles and other surfaces with polypeptides are described.

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“…The size of reduction-sensitive micelles based on disulfide-cored octaarmed SS-8s-PCL-b-PEG copolymer was reduced into half, and the DOX release rate was markedly increased upon the addition of 10 mM DTT (63). In a previous study, reduction and thermo dual-sensitive polypeptide micelles prepared from disulfide-cored tetra-armed polypeptide SS-4s-poly (diethylene glycol-l-glutamate) were reduced into half-sized micelles in response to 10 mM DTT (41). Reduction and pH dual-sensitive micelles were obtained from PEG-bpolyurethane-b-PEG triblock copolymer containing multiple disulfide bonds and tertiary amine groups in the polyurethane (PU) block (91).…”

Section: Reduction-sensitive Disassemblable Micelles With a Reductivementioning

confidence: 99%

Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release

Sun

Meng

Cheng

et al. 2014

Antioxidants & Redox Signaling

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Significance: The therapeutic effects of current micellar and vesicular drug formulations are restricted by slow and inefficient drug release at the pathological site. The development of smart polymeric nanocarriers that release drugs upon arriving at the target site has received a tremendous amount of attention for cancer therapy. Recent Advances: Taking advantage of a high reducing potential in the tumor tissues and in particular inside the tumor cells, various reduction-sensitive polymeric micelles and vesicles have been designed and explored for triggered anticancer drug release. These reduction-responsive nanosystems have demonstrated several unique features, such as good stability under physiological conditions, fast response to intracellular reducing environment, triggering drug release right in the cytosol and cell nucleus, and significantly improved antitumor activity, compared to traditional reduction-insensitive counterparts. Critical Issues: Although reductionsensitive micelles and polymersomes have accomplished rapid intracellular drug release and enhanced in vitro antitumor effect, their fate inside the cells including the mechanism, site, and rate of reduction reaction remains unclear. Moreover, the systemic fate and performance of reduction-sensitive polymeric drug formulations have to be investigated. Future Directions: Biophysical studies should be carried out to gain insight into the degradation and drug release behaviors of reduction-responsive nanocarriers inside the tumor cells. Furthermore, novel ligand-decorated reduction-sensitive nanoparticulate drug formulations should be designed and explored for targeted cancer therapy in vivo. Antioxid. Redox Signal. 21, 755-767.

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Reduction- and thermo-sensitive star polypeptide micelles and hydrogels for on-demand drug delivery

Abstract: Dual stimuli-sensitive star polypeptide was for the first time synthesized and self-assembled into reduction- and thermo-sensitive micelles and hydrogels, demonstrating tunable size, mechanical and triggered drug-release properties useful for on-demand drug delivery.

Cited by 78 publications

References 38 publications

Thermoresponsive and Mechanical Properties of Poly(l-proline) Gels

Thermoresponsive and Mechanical Properties of Poly(l-proline) Gels

Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures

Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release

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