Reduction and functionalization of graphene oxide with L-cysteine: Synthesis, characterization and biocompatibility

Abdelhalim, Abdelsattar O.E.; Sharoyko, Vladimir V.; Meshcheriakov, Anatolii A.; Martynova, Sofia D.; Ageev, Sergei V.; Iurev, Gleb O.; Mulla, Hadeer Al; Petrov, Andrey V.; Solovtsova, Irina L.; Vasina, Lubov V.; Murin, I. V.; Semenov, Konstantin N.

doi:10.1016/j.nano.2020.102284

Cited by 32 publications

(29 citation statements)

References 63 publications

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“…In the spectrum of the modified PPO/GO (0.7%) membrane, characteristic peaks of GO are not observed: the wide peak around 3440 cm −1 related to the -OH stretching of the carboxylic group, the peak at 1718 cm −1 attributed to the C=O stretching of the carboxylic groups, the peak at 1630 cm −1 corresponded to the C=C stretch of the aromatic domain of graphene, etc. [48,49]. These bands may be invisible due to the low GO content in the membrane matrix and indicate weak interactions between the polymer and the particles of the modifier.…”

Section: The Study Of the Dense Membranesmentioning

confidence: 99%

Novel Mixed Matrix Membranes Based on Polyphenylene Oxide Modified with Graphene Oxide for Enhanced Pervaporation Dehydration of Ethylene Glycol

et al. 2022

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Ethylene glycol (EG) is widely used in various economic and industrial fields. The demand for its efficient separation and recovery from water is constantly growing. To improve the pervaporation characteristics of a poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) membrane in dehydration of ethylene glycol, the modification with graphene oxide (GO) nanoparticles was used. The effects of the introduction of various GO quantities into the PPO matrix on the structure and physicochemical properties were studied by Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies, scanning electron (SEM) and atomic force (AFM) microscopies, thermogravimetric analysis (TGA), swelling experiments, and contact angle measurements. Two types of membranes based on PPO and PPO/GO composite were developed: dense membranes and supported membranes on a fluoroplast substrate (MFFC). Transport properties of the developed membranes were evaluated in the pervaporation dehydration of EG in a wide concentration range (10–90 wt.% and 10–30 wt.% water for the dense and supported membranes, respectively). The supported PPO/GO(0.7%)/MFFC membrane demonstrated the best transport properties in pervaporation dehydration of EG (10–30 wt.% water) at 22 °C: permeation flux ca. 15 times higher compared to dense PPO membrane—180–230 g/(m2·h)), 99.8–99.6 wt.% water in the permeate. The membrane is suitable for the promising industrial application.

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Section: The Study Of the Dense Membranesmentioning

confidence: 99%

Novel Mixed Matrix Membranes Based on Polyphenylene Oxide Modified with Graphene Oxide for Enhanced Pervaporation Dehydration of Ethylene Glycol

et al. 2022

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“…The main PC parameters measured in the reviewed articles were thickness, lateral size, zeta potential, and hydrodynamic diameter. However, although not so commonly, other parameters such as surface area [ 54 , 55 , 56 ], chemical composition [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ], impurity concentration [ 56 , 57 , 63 , 64 , 67 , 68 ], aggregation/agglomeration [ 54 , 60 , 63 , 64 , 69 , 70 ], morphology and/or surface characteristics [ 55 , 57 , 71 , 72 ], thermal stability [ 67 ], elasticity [ 56 ], precipitation in suspension [ 65 ], number of layers [ 54 , 57 , 60 , 61 , 63 , 64 , 71 , 73 , 74 , 75 , 76 , 77 ] hydrophobicity [ …”

Section: Resultsmentioning

confidence: 99%

Genotoxicity of Graphene-Based Materials

et al. 2022

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Graphene-based materials (GBMs) are a broad family of novel carbon-based nanomaterials with many nanotechnology applications. The increasing market of GBMs raises concerns on their possible impact on human health. Here, we review the existing literature on the genotoxic potential of GBMs over the last ten years. A total of 50 articles including in vitro, in vivo, in silico, and human biomonitoring studies were selected. Graphene oxides were the most analyzed materials, followed by reduced graphene oxides. Most of the evaluations were performed in vitro using the comet assay (detecting DNA damage). The micronucleus assay (detecting chromosome damage) was the most used validated assay, whereas only two publications reported results on mammalian gene mutations. The same material was rarely assessed with more than one assay. Despite inhalation being the main exposure route in occupational settings, only one in vivo study used intratracheal instillation, and another one reported human biomonitoring data. Based on the studies, some GBMs have the potential to induce genetic damage, although the type of damage depends on the material. The broad variability of GBMs, cellular systems and methods used in the studies precludes the identification of physico-chemical properties that could drive the genotoxicity response to GBMs.

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“…This effect increased the penetration of the GO-DOX conjugate into the interstitial space of mouse liver carcinoma through damaged capillaries. Over past few years, a series of works was published at the Department of General and Bioorganic Chemistry (Pavlov University, St. Petersburg) which demonstrated an opportunity of reducing toxicity to acceptable level, due to functionalisation of the graphene carrier [52][53][54]. Moreover, the graphene-based nanomaterials (GBN) have been shown to have a number of advantages: stimulation of immune response, inhibition of tumour stem cells, regulation of angiogenesis and hypoxia [55].…”

Section: Current Experience With Graphene Carriersmentioning

confidence: 99%

“…2). Reduced GO (rGO) is a variant of GO in which most of the oxygen-containing functional groups are reduced by means of hydrazine hydrate or biomolecules [54,62].…”

Section: Current Experience With Graphene Carriersmentioning

confidence: 99%

Mutual influence of malignant cells and cellular microenvironment: prospects for manipulating tumour microenvironment with nanomaterials

Malkova¹,

Ageev²,

Abdelhalim³

et al. 2022

CTT

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Development and progression of neoplasia occurs in parallel with changes in the surrounding stroma. Cancer cells may functionally reshape their microenvironment by secreting various cytokines, chemokines and generation of acidic medium. These factors contribute to differentiation of immune cells into immunosuppressive phenotype, stimulate the synthesis of a number of amino acid metabolism enzymes, growth factors, adhesion molecules, which promote invasion, angiogenesis and metastasis, and also reduce efficiency of anticancer drugs and radiation therapy. To increase effectiveness of the chemotherapy, multitargeted carbon nanomaterials may be applied. In particular, nanomaterials based on modified graphene make it possible to create multicomponent therapeutic constructs, including macromolecules, polymers, and effector agents. Initial experiments with unmodified graphenes demonstrated their toxicity associated with their accumulation in parenchymal organs and initiation of inflammatory processes. In the past few years, a series of works has been published in which the possibility of reducing the toxicity of graphene oxide through functionalisation has been demonstrated. This review summarises the experimental data on the creation of covalent and non-covalent conjugates based on graphene oxide and demonstrates their in vitro efficacy on various tumour cell lines. Separately, there are few data on the effect of nanomaterials based on graphene oxide on the tumour microenvironment.

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Reduction and functionalization of graphene oxide with L-cysteine: Synthesis, characterization and biocompatibility

Cited by 32 publications

References 63 publications

Novel Mixed Matrix Membranes Based on Polyphenylene Oxide Modified with Graphene Oxide for Enhanced Pervaporation Dehydration of Ethylene Glycol

Novel Mixed Matrix Membranes Based on Polyphenylene Oxide Modified with Graphene Oxide for Enhanced Pervaporation Dehydration of Ethylene Glycol

Genotoxicity of Graphene-Based Materials

Mutual influence of malignant cells and cellular microenvironment: prospects for manipulating tumour microenvironment with nanomaterials

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