Reducing Visceral-Motion-Related Artifacts on the Liver with Dual-Energy CT: A Comparison of Four Different CT Scanner Techniques

Grosu, Sergio; Vijittrakarnrung, Korawan; Wang, Zhen J.; Obmann, Markus M; Sun, Yuxin; Sugi, Mark; Yeh, Benjamin M.

doi:10.3390/diagnostics12092155

Cited by 2 publications

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References 28 publications

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“…The use of DECT techniques has very recently attracted interest in different clinical applications, including diagnostics; for example using DECT for the improved detection of portal vein thrombosis via virtual monoenergetic reconstructions [ 19 ], for reducing visceral-motion-related artifacts on the liver by comparing different CT scanner techniques [ 20 ], or also using DECT of the heart to the study of coronary artery disease [ 21 ].…”

Section: Background and Related Workmentioning

confidence: 99%

DECT-CLUST: Dual-Energy CT Image Clustering and Application to Head and Neck Squamous Cell Carcinoma Segmentation

et al. 2022

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Dual-energy computed tomography (DECT) is an advanced CT computed tomography scanning technique enabling material characterization not possible with conventional CT scans. It allows the reconstruction of energy decay curves at each 3D image voxel, representing varied image attenuation at different effective scanning energy levels. In this paper, we develop novel unsupervised learning techniques based on mixture models and functional data analysis models to the clustering of DECT images. We design functional mixture models that integrate spatial image context in mixture weights, with mixture component densities being constructed upon the DECT energy decay curves as functional observations. We develop dedicated expectation–maximization algorithms for the maximum likelihood estimation of the model parameters. To our knowledge, this is the first article to develop statistical functional data analysis and model-based clustering techniques to take advantage of the full spectral information provided by DECT. We evaluate the application of DECT to head and neck squamous cell carcinoma. Current image-based evaluation of these tumors in clinical practice is largely qualitative, based on a visual assessment of tumor anatomic extent and basic one- or two-dimensional tumor size measurements. We evaluate our methods on 91 head and neck cancer DECT scans and compare our unsupervised clustering results to tumor contours traced manually by radiologists, as well as to several baseline algorithms. Given the inter-rater variability even among experts at delineating head and neck tumors, and given the potential importance of tissue reactions surrounding the tumor itself, our proposed methodology has the potential to add value in downstream machine learning applications for clinical outcome prediction based on DECT data in head and neck cancer.

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Section: Background and Related Workmentioning

confidence: 99%