Reducing the Number of Subunits in the CAMKIIα Holoenzyme Alters Catalytic Domain Pairing, Diffusion Time, and T286 Autophosphorylation

Abstract

Calcium/calmodulin dependent protein kinase II (CaMKII) is a family of multifunctional Ser/Thr kinases that play a key role in calcium signaling in many cell types, including neurons, where it performs both structural and signaling roles in learning and memory. CaMKII exists as a dodecameric holoenzyme.