Reducing the Global Burden of Congenital Rubella Syndrome: Report of the World Health Organization Steering Committee on Research Related to Measles and Rubella Vaccines and Vaccination, June 2004

Abstract

Rubella and congenital rubella syndrome (CRS) continue to be important health problems in many countries. In June 2004, the World Health Organization Steering Committee on Research Related to Measles and Rubella Vaccines and Vaccination met to evaluate data from research and operational activities and to identify critical scientific issues and gaps in knowledge that need to be addressed to improve the global control of rubella and CRS. Information about surveillance for rubella, natural and vaccine-induced immunity to rubella, laboratory diagnosis, the molecular epidemiological profile of rubella virus, and mathematical modeling to assess the burden of CRS and the impact of rubella vaccination was reviewed. This report summarizes the presentations and recommendations for future research.

Soroprevalência da rubéola na população urbana e rural de Guaratinguetá

“…Até o final da década de 1980 era desconhecida a verdadeira magnitude da rubéola na maior parte dos países da América Latina, incluindo o Brasil. Nos últimos anos, estudos de soroprevalência vem sendo realizados em alguns grupos populacionais, cujos resultados vêm norteando a definição e a implementação de estratégias de vacinação 4,5,6,7,8 . …”

Quantitative and qualitative assay of rubella IgA antibody in breast milk

“…Since the introduction of vaccination programs, rubella and CRS have been dramatically reduced in developed countries [CDC, 2005]. However, the diseases are still endemic in developing countries [Best et al, 2005]. Rubella vaccination is strongly recommended by WHO for prevention of rubella as well as CRS.…”

Phylogenetic analysis of rubella viruses found in Morocco, Uganda, Cote d’Ivoire and South Africa from 2001 to 2007

“…Collection of genetic baseline data on RVs was identified by the 2004 WHO Steering Committee on Research Related to Measles and Rubella Vaccines and Vaccination as necessary to improve global control of rubella and CRS (Best et al, 2005). RV molecular epidemiologic data have contributed significantly to rubella control efforts (e.g., elimination of rubella from the United States) and also to the understanding of the worldwide genetic diversity of RVs (Best et al, 2005;Icenogle et al, 2006).…”