Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings

Horne, Ryan R.; Ben‐Shlomo, Nir; Foggia, Megan J.; Ellerman, Morgan; Escudero, Caleb; Hua, Rong; Bennion, Douglas M; Guymon, C. Allan; Hansen, Marlan R.

doi:10.1016/j.actbio.2023.05.011

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…Overall, short-term durability of photografted zwitterionic hydrogels in vivo and significant reduction of fibrosis were demonstrated. Additionally, recently published results for similar systems show minimal scarring and inflammation, with no evidence of degradation or loss of function, up to one year in vivo …”

Section: Resultsmentioning

confidence: 99%

“…The samples were then prepared for capsule analysis, as described previously . Briefly, the samples were fixed overnight in 4% paraformaldehyde (Sigma-Aldrich) in PBS, processed through increased concentrations of sucrose in PBS, and then embedded vis Tissue-Tek OCT (Thermo Fisher Scientific) compound via flash liquid nitrogen freezing.…”

Section: Methodsmentioning

confidence: 99%

“…The samples were then prepared for capsule analysis, as described previously. 41 Briefly, the samples were fixed overnight in 4% paraformaldehyde (Sigma-Aldrich) in PBS, processed through increased concentrations of sucrose in PBS, and then embedded vis Tissue-Tek OCT (Thermo Fisher Scientific) compound via flash liquid nitrogen freezing. Sections were prepared on a LEICA CryoJane system at a thickness of 20 μm to preserve tissue architecture despite the difference in compressive modulus between biological dermis and PDMS.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, recently published results for similar systems show minimal scarring and inflammation, with no evidence of degradation or loss of function, up to one year in vivo. 41 3.2. Lubricity Following Implantation in Mice.…”

Section: Durability Of Thin Filmsmentioning

confidence: 99%

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Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants

Peel,

Bennion,

Horne

et al. 2024

ACS Appl. Bio Mater.

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The durability of photografted zwitterionic hydrogel coatings on cochlear implant biomaterials was examined to determine the viability of these antifouling surfaces during insertion and long-term implant usage. Tribometry was used to determine the effect of zwitterionic coatings on the lubricity of surfaces with varying hydration levels, applied normal force, and time frame. Additionally, flexural resistance was investigated using mandrel bending. Ex vivo durability was assessed by determining the coefficient of friction between tissues and treated surfaces. Furthermore, cochlear implantation force was measured using cadaveric human cochleae. Hydrated zwitterionic hydrogel coatings reduced frictional resistance approximately 20-fold compared to uncoated PDMS, which led to significantly lower mean force experienced by coated cochlear implants during insertion compared to uncoated systems. Under flexural force, zwitterionic films resisted failure for up to 60 min of desiccation. The large increase in lubricity was maintained for 20 h under continual force while hydrated. For loosely cross-linked systems, films remained stable and lubricious even after rehydration following complete drying. All coatings remained hydrated and functional under frictional force for at least 30 min in ambient conditions allowing drying, with lower cross-link densities showing the greatest longevity. Moreover, photografted zwitterionic hydrogel samples showed no evidence of degradation and nearly identical lubricity before and after implantation. This work demonstrates that photografted zwitterionic hydrogel coatings are sufficiently durable to maintain viability before, during, and after implantation. Mechanical properties, including greatly increased lubricity, are preserved after complete drying and rehydration for various applied forces. Additionally, this significantly enhanced lubricity translates to significantly decreased force during insertion of implants which should result in less trauma and scarring.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Durability Of Thin Filmsmentioning

confidence: 99%

See 2 more Smart Citations

Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants

Peel,

Bennion,

Horne

et al. 2024

ACS Appl. Bio Mater.

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show abstract

“…Horne et al employed photopolymerization and photo-grafting cross-linking techniques, introducing carboxybetaine methacrylate (CBMA) into PDMS to create a durable polyCBMA (pCBMA) film. 161 This film demonstrates robust anti-fouling properties when implanted in vivo . Prior research indicates that, compared to other zwitterions, CBMA typically exhibits superior anti-fouling, hydration, and mechanical performance.…”

Section: Application Of Biomaterials In the Treatment Of Snhlmentioning

confidence: 97%