The concept of prospective 3D affine motion correction was generalized, based on the Bloch equations, for signal excitation and sampling using arbitrary MR sequences. The technique was implemented on a clinical MRI scanner for Cartesian, radial, and spiral imaging sequences, as well as for 2D spatially selective RF excitation pulses. A patient-specific motion model steered by real-time navigators was employed to account for the additional degrees of freedom provided by the affine motion model. Different navigator concepts (multiple spatial and temporal navigators, quadratic navigators and other motion sensors) were investigated, with the aim of improving the correlation between navigator information and the motion model. Many MR imaging (MRI) and spectroscopy (MRS) applications suffer from motion artifacts caused by, e.g., respiratory and cardiac motion. Currently employed real-time gating techniques, such as EKG triggering and navigatorbased respiratory gating (1), reduce motion artifacts considerably but result in a strong increase in scan time. Hence, motion-correction techniques, which allow the acquisition of MR data in the presence of motion, are highly desirable. Slice-tracking approaches based on respiratory navigators have been shown to improve image quality in coronary MRA (2). However, due to the simplicity of the underlying 1D translatory motion model, only small gating windows (typically 5 mm) can be applied (3). Recently a patient-specific calibration approach was introduced for coronary MRA that allows the prediction of affine transformation parameters, including 3D translation, rotation, scale, and shear motion, from navigator measurements (4). In addition, a prospective correction of affine motion was proposed. However, the technical complexity of such an approach limited the implementation to prospective correction of 3D translation and 1D expansion for Cartesian imaging sequences. Furthermore, additional offline processing was required, which challenged the practical feasibility of the method in a clinical workflow.In the current work, prospective motion correction is discussed in the framework of the Bloch equations, which conceptually overcomes the restriction to Cartesian imaging sequences. Thus, the approach is generalized to signal excitation and sampling for arbitrary MRI sequences, such as multidimensional excitation pulses and non-Cartesian imaging sequences. Following the theoretical treatment, the technique is fully implemented on a clinical scanner in a sequence-independent manner, which enables the employment of a full 3D affine transformation for all available pulse and imaging sequences, including Cartesian, radial, and spiral scanning, as well as 2D excitation pulses. The results of phantom experiments are presented that prove the technical feasibility of the approach, whereas initial in vivo results demonstrate the potential for coronary MRA and abdominal imaging.
THEORYThe principles of affine motion correction may be derived directly from the Bloch equations. The Bloch equati...