Reducing ion diffusion at atmospheric pressure through intermingled positive and negative ions

Ewing, Robert G.; Hart, Garret L.; Nims, Megan K.; Murphy, Shannon; Johnson, Samantha I.; Chun, Jaehun; Denis, Elizabeth

doi:10.1016/j.ijms.2023.117115

Cited by 1 publication

(1 citation statement)

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“…At high ion concentrations that lead to space-charge induced electric fields approaching or exceeding the electrode-prescribed electric field (an ion concentration of 10 7 cm −1 is equivalent to an electric field change of 18 V cm −1 cm −1 ), space charge ceases to be a minor perturbation to ion trajectories but becomes their primary driver. Avenues for improvement (e.g., Ewing et al, 2023) will constitute a future study.…”

Section: Eisele Type Inletmentioning

confidence: 99%

Multiphysical description of atmospheric pressure interface chemical ionisation in MION2 and Eisele type inlets

Finkenzeller,

Mikkilä,

Righi

et al. 2024

Preprint

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Abstract. Chemical ionisation inlets are fundamental instrument components in chemical ionisation mass spectrometry (CIMS). However, the sample gas and reagent ion trajectories are often understood only in a general and qualitative manner. Here we evaluate two atmospheric pressure chemical ionisation inlets (MION2 and Eisele type inlet) with computational fluid dynamics 3D physico-chemical models regarding the reagent ion and sample gas trajectories and estimate their efficiencies of reagent ion production, reagent ion delivery from the ion source volume into the ion–molecule mixing region, and the interaction between reagent ions and target molecules. The models are validated by laboratory measurements and quantitatively reproduce observed sensitivities to tuning parameters, including ion currents and changes in mass spectra. The study elucidates how the different transport and chemical reactions proceed within the studied inlets, that space charge can already be relevant at ion concentrations of as low as 107 cm−3, and compares the two investigated inlet models. The models provide insights into how to operate the inlets and will help in the development of future inlets that further enhance the capability of CIMS.

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Section: Eisele Type Inletmentioning

confidence: 99%