Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial

Vano, Michele; Derchi, Giacomo; Barone, Antonio; Pinna, Roberto; Usai, P; Covani, Ugo

doi:10.1007/s00784-017-2113-3

Cited by 92 publications

(90 citation statements)

References 41 publications

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“…Hydroxyapatite nanoparticles have been incorporated in different commercial oral care products [4,18,19] and according to the manufacturer, the maximum incorporation of this 15.5% HAP-NP aqueous suspension oral care ingredient in a toothpaste is 20% and in a mouthwash is 10%. Considering this, it was decided to test a final concentration of 20% dilution of the HAP-NP aqueous suspension, which corresponds to 3.1% HAP-NP.…”

Section: Discussionmentioning

confidence: 99%

“…Hydroxyapatite nanoparticles (HAP-NP) are very similar to natural hydroxyapatite in terms of size and crystal structure, which contributes to their use in oral care treatments [2]. In recent years, HAP-NP have been incorporated in oral care products such as toothpastes and mouthwashes with the aim of treating dental sensitivity by occluding the dentinal tubules that are opened to the dentin surface and connected to the pulp; or with the purpose of promoting enamel remineralisation by replacing calcium and phosphate ions to areas from which minerals have dissolved, restoring its integrity and gloss [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation

et al. 2018

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Hydroxyapatite nanoparticles (HAP-NP) are incorporated in oral care products such as toothpastes and mouthwashes to treat dental sensitivity or to promote enamel remineralisation. Despite the good performance of HAP-NP in this application, it is important to ensure its safety for consumers. For that reason, the Scientific Committee on Consumer Safety (SCCS) evaluated the safety of HAP-NP as an oral care ingredient, but the issued opinion was not completely conclusive and the SCCS recommended that additional tests should be performed. Here, we used a commercially available human gingival epithelium (HGE) as a non-animal alternative and MTT cell viability, LDH activity, and IL-1alpha production were evaluated after 3.1% HAP-NP treatment for 10 min, 1 h, and 3 h. Moreover, the absorption of HAP-NP in the gingival tissue was assessed by transmission electron microscopy (TEM) analysis. Finally, the dissolution behaviour of HAP-NP in simulated gastric fluid was also investigated. No deleterious effect was observed for HGE tissues incubated with HAP-NP for all time-points and parameters evaluated. Moreover, a complete dissolution of 3.1% HAP-NP in simulated gastric fluid was observed after 7.5 min at 37 °C. In conclusion, our results evidence the safety of HAP-NP for oral care products with the use of an in vitro replacement alternative for human gingival epithelium and a simulated gastric fluid assay.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation

et al. 2018

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“…[18][19][20][21][22] Oral care formulations based on particulate HAP have been shown to be efficient in addressing a number of clinical indications such as prophylaxis against caries 23,24 and protection from dentin hypersensitivity by the occlusion of open dentin tubuli. [25][26][27][28] Additional effects are, for example, the improvement of periodontal health, 29 the formation of a protective layer on enamel, 30,31 biofilm management 16,32 and tooth whitening. 33 The necessary condition for HAP particles to take effect is that they come into contact with the tooth surface.…”

Section: Introductionmentioning

confidence: 99%

Quantitative affinity parameters of synthetic hydroxyapatite and enamel surfaces in vitro

Fabritius-Vilpoux

Enax

Herbig

et al. 2019

Bioinspired, Biomimetic and Nanobiomaterials

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Particulate synthetic hydroxyapatite (HAP) is rapidly gaining importance as a biomimetic agent in oral care products. The prerequisite for an adequate effect of the treatment is an efficient attachment of the HAP particles to the tooth substance. However, quantitative data about the interaction and affinity parameters involved are scarce. The authors used an in vitro approach with standardized bovine tooth enamel surfaces and aqueous dispersions of chemically pure synthetic HAP particles as a model system. Structural characterization of the HAP powder using high-resolution scanning electron microscopy (SEM) shows that the particles are micrometer-sized stable clusters of crystallites that closely resemble the structure of natural enamel. Using SEM image analysis, the authors investigated the influence of HAP particle concentration and particle size on the efficiency of attachment to bovine tooth enamel based on pure mineral-mineral interaction. The results show that both play an important role and can be tailored for optimizing the efficiency of corresponding oral care formulations. The results also reveal the presence of structures resembling mineral bridges at the interfaces between HAP particles and enamel that provide indications for possible interaction mechanisms. Notation A r aspect ratio d max crystallite length d min crystallite width N particles number of particles 141 Cite this article

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“…The above mentioned effectiveness of nHAp in the management of DH is further supported by numerous clinical studies [26,[48][49][50]. Browning and his team investigated the effect nHAp paste on bleaching-related tooth sensitivity [48].…”

Section: Nano Hydroxyapatites Crystalsmentioning

confidence: 97%

The Effectiveness of Nanomaterials in the Management of Dentine Hypersensitivity-A Review

2018

JCRC

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Dentin hypersensitivity [DH] associated with short sharp pain is a public health concern with a dire consequence to good oral health hygiene. Although different materials and desensitizing toothpastes have flooded the market with claim to provide relief for DH patients by occluding patent dentinal tubules, their occluding abilities have been limited. As such, a new strategy it’s required to effectively manage DH. The use of nanomaterial for dentinal tubules occlusion is predicted to revolutionize the treatment of DH. This article aimed to review the effectiveness of nanomaterials in the management of DH.

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Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial

Abstract: The application of nano-hydroxyapatite in gel toothpaste fluoride free is an effective desensitizing agent providing relief from symptoms after 2 and 4 weeks.

Cited by 92 publications

References 41 publications

Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation

Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation

Quantitative affinity parameters of synthetic hydroxyapatite and enamel surfaces in vitro

The Effectiveness of Nanomaterials in the Management of Dentine Hypersensitivity-A Review

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