This paper presents the establishment of a relationship between coil spring fatigue life and automotive vertical vibration using neural network. During an automotive suspension design process, the suspension components are designed with the consideration of structure strength and fatigue life as well as the effects toward automotive ride. Hence, it is important to have a functional mathematical model to predict the fatigue life and automotive life simultaneously. To build the mathematical model, a multibody kinematic quarter model of suspension system was constructed to simulate force and acceleration time histories from the suspension system and the sprung mass of the vehicle model. The force time histories were used to predict the fatigue life of the coil spring while the acceleration time histories were converted into ISO vertical vibration index. A neural network model was created and used to fit the spring fatigue life and vehicle vertical vibration into a mathematical function. The neural network with 1 hidden layer and 2 neurons has shown a good fitting of the data with coefficient of determination as high as 0.88, 0.98, 0.96 for training, validation and testing, respectively. This constructed neural network serves to predict the vehicle vertical vibration using the spring fatigue life and suspension natural frequencies as input, and hence reduce the automotive suspension design process.