Reducing Clostridium difficile Infection Among Hematology-Oncology Patients Using Ultraviolet Germicidal Irradiation for Terminal Room Disinfection

Pegues, David A.; Gilmar, Cheryl; Denno, Mary; Gaynes, Steven

doi:10.1093/ofid/ofv133.1265

Cited by 3 publications

(4 citation statements)

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“…Multiple clinical trials have assessed the efficacy of UV or hydrogen peroxide room decontamination units for reducing HAIs (Table 4). 56,[65][66][67][68][69][70][71][72][73][74] Several studies warrant detailed discussion, including the studies by Passaretti et al, 67 Pegues et al, 73 and Anderson et al 74 Passaretti et al performed a 30-month prospective cohort (before-after study) intervention using a hydrogen peroxide vapor device (Bioquell) on 6 high-risk units in a 994-bed tertiary care hospital. 67 Patients admitted to rooms decontaminated using HPV were 64% less likely to acquire any multidrug-resistant pathogen (IRR, 0.36; P < .001) and 80% less likely to acquire VRE (IRR, 0.20; P < .001).…”

Section: Clinical Trials Using Hpv Room Decontamination Devicesmentioning

confidence: 99%

“…Pegues et al performed a prospective cohort (before-after study) in 3 hematology-oncology units to assess the efficacy of a UV-C device (Optimum) to reduce C difficile infection. 73 Importantly, rooms were disinfected with bleach prior to use of the UV-C device. A significant association between UV-C use and a decline in C difficile infection incidence was noted on study units (IRR, 0.49; 95% confidence interval, 0.26-0.94; P = .03) but not on the nonstudy units (IRR, 0.63; 95% confidence interval, 0.38-1.06; P = .08).…”

Section: Clinical Trials Using Hpv Room Decontamination Devicesmentioning

confidence: 99%

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Effectiveness of ultraviolet devices and hydrogen peroxide systems for terminal room decontamination: Focus on clinical trials

Weber

Rutala

Anderson

et al. 2016

American Journal of Infection Control

159

148

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Over the last decade, substantial scientific evidence has accumulated that indicates contamination of environmental surfaces in hospital rooms plays an important role in the transmission of key health care-associated pathogens (eg, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, Clostridium difficile, Acinetobacter spp). For example, a patient admitted to a room previously occupied by a patient colonized or infected with one of these pathogens has a higher risk for acquiring one of these pathogens than a patient admitted to a room whose previous occupant was not colonized or infected. This risk is not surprising because multiple studies have demonstrated that surfaces in hospital rooms are poorly cleaned during terminal cleaning. To reduce surface contamination after terminal cleaning, no touch methods of room disinfection have been developed. This article will review the no touch methods, ultraviolet light devices, and hydrogen peroxide systems, with a focus on clinical trials which have used patient colonization or infection as an outcome. Multiple studies have demonstrated that ultraviolet light devices and hydrogen peroxide systems have been shown to inactivate microbes experimentally plated on carrier materials and placed in hospital rooms and to decontaminate surfaces in hospital rooms naturally contaminated with multidrug-resistant pathogens. A growing number of clinical studies have demonstrated that ultraviolet devices and hydrogen peroxide systems when used for terminal disinfection can reduce colonization or health care-associated infections in patients admitted to these hospital rooms.

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Section: Clinical Trials Using Hpv Room Decontamination Devicesmentioning

confidence: 99%

Section: Clinical Trials Using Hpv Room Decontamination Devicesmentioning

confidence: 99%

Effectiveness of ultraviolet devices and hydrogen peroxide systems for terminal room decontamination: Focus on clinical trials

Weber

Rutala

Anderson

et al. 2016

American Journal of Infection Control

159

148

View full text Add to dashboard Cite

show abstract

“…Several studies warrant detailed discussion, including the studies by Passaretti et al [53], by Pegues et al [47], and by Anderson et al [46]. Passaretti et al [53] performed a 30-month prospective cohort (before-after study that was strengthened by the use of concurrent controls) intervention using a HPV device on six high-risk units in a 994-bed Pegues et al [47] performed a prospective cohort (before-after study) in three haematology-oncology units to assess the efficacy of a UV-C device to reduce C. difficile infections (CDIs). Importantly, rooms were disinfected with bleach prior to use of the device.…”

Section: Clinical Trials Using 'No Touch' Room Decontamination Methodsmentioning

confidence: 99%

‘No touch’ technologies for environmental decontamination: focus on ultraviolet devices and hydrogen peroxide systems

Weber

Kanamori

Rutala

2016

Current Opinion in Infectious Diseases

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Many studies have demonstrated that terminal cleaning and disinfection with germicides is often inadequate and leaves environmental surfaces contaminated with important nosocomial pathogens. 'No touch' methods of room decontamination (i.e., UV devices and hydrogen peroxide systems) have been demonstrated to reduce key nosocomial pathogens on inoculated test surfaces and on environmental surfaces in actual patient rooms. Further UV devices and hydrogen peroxide systems have been demonstrated to reduce HAI. A validated 'no touch' device or system should be used for terminal room disinfection following discharge of patients on contact precautions. The use of a 'self-disinfecting' surface to reduce HAI has not been convincingly demonstrated.

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“…Moreover, they reduce microbial contamination substantially [69•, 70•] and they have been used to control outbreaks in healthcare facilities [69•]. Studies to date have demonstrated that hydrogen peroxide vapor significantly decreased acquisition of any multidrug-resistant organism [74•], that UV-C use was associated with a significantly decreased incidence of C. difficile infections [75], and that terminal room decontamination enhanced with both bleach and UV-C light significantly decreased the risk of acquiring a target organism (i.e., MRSA, VRE, or C. difficile multidrug-resistant Acinetobacter) [45]. However, these technologies are expensive and they increase the time needed for terminal room disinfection.…”

Section: Technology Use In Infection Prevention and Controlmentioning

confidence: 99%

Role of Human Factors Engineering in Infection Prevention: Gaps and Opportunities

Pennathur

Herwaldt

2017

Curr Treat Options Infect Dis

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Opinion statementHuman factors engineering (HFE), with its focus on studying how humans interact with systems, including their physical and organizational environment, the tools and technologies they use, and the tasks they perform, provides principles, tools, and techniques for systematically identifying important factors, for analyzing and evaluating how these factors interact to increase or decrease the risk of Healthcare-associated infections (HAI), and for identifying and implementing effective preventive measures. We reviewed the literature on HFE and infection prevention and control and identified major themes to document how researchers and infection prevention staff have used HFE methods to prevent HAIs and to identify gaps in our knowledge about the role of HFE in HAI prevention and control. Our literature review found that most studies in the healthcare domain explicitly applying (HFE) principles and methods addressed patient safety issues not infection prevention and control issues. In addition, most investigators who applied human factors principles and methods to infection prevention issues assessed only one human factors element such as training, technology evaluations, or physical environment design. The most significant gap pertains to the limited use and application of formal HFE tools and methods. Every infection prevention study need not assess all components in a system, but investigators must assess the interaction of critical system components if they want to address latent and deep-rooted human factors problems.

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Reducing Clostridium difficile Infection Among Hematology-Oncology Patients Using Ultraviolet Germicidal Irradiation for Terminal Room Disinfection

Cited by 3 publications

References 0 publications

Effectiveness of ultraviolet devices and hydrogen peroxide systems for terminal room decontamination: Focus on clinical trials

Effectiveness of ultraviolet devices and hydrogen peroxide systems for terminal room decontamination: Focus on clinical trials

‘No touch’ technologies for environmental decontamination: focus on ultraviolet devices and hydrogen peroxide systems

Role of Human Factors Engineering in Infection Prevention: Gaps and Opportunities

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