Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis

Parker, Patrick D.; Hou, Xintong; Dong, Vy M.

doi:10.1021/jacs.1c00750

Cited by 38 publications

(12 citation statements)

References 318 publications

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“…Bahan perisa baik dari reduksi dan oksidasi perlu dipastikan kehalalannya lebih lanjut disebabkan bahan penyusunnya dapat berasal dari hewani. Bahan perisa dari hidrogenasi serupa dengan reaksi reduksi dengan penambahan katalis (Parker et al 2021). Katalis sebagai bahan penolong perlu dipastikan bukan berasal dari hewani.…”

Section: Proses Produksi Bahan Perisa Kritis Halalunclassified

Profil Bahan Perisa Kritis Halal dalam Peraturan BPOM No. 13/2020

2022

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Flavors play a role as a determinant of the acceptability of food product. Halal certificate is a required document in Indonesia. Halal material requirements refer to SK11/Dir/LPPOM MUI/VI/20. This study aimed to obtain a profile of halal critical flavoring materials in BPOM regulation no. 13/2020 based on the document requirements for halal materials in LPPOM's SK11 and propose for non-critical halal flavoring materials. Materials used in this study were data-from BPOM regulation no. 13/2020, halal material requirements SK11/Dir/LPPOM MUI/VI/20 and other literatures associated with material production process information. The research method includes data collection based on CAS numbering, determination of BPOM flavoring materials outside the list of non-critical halal materials, determination of the production process for flavoring material, mapping of halal critical flavoring materials. The results showed that 53.82% (1381/2566) of the flavoring materials in BPOM regulations were halal critical materials. Based on identification results there were 26 types of production processes that have different halal critical sources that affect the required halal supporting documents. 65.38% (17/26) of critical halal sources came from raw materials, 30.77% (8/26) critical halal sources came from raw materials and manufacturing processes. The criticality of halal flavoring materials depends on the source of the raw material and the production process. Flavors obtained from the chemical synthesis process (414/1381) can be proposed as non-critical halal flavorings.

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Section: Proses Produksi Bahan Perisa Kritis Halalunclassified

Profil Bahan Perisa Kritis Halal dalam Peraturan BPOM No. 13/2020

2022

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“…Keeping all these in perspective, arene hydrogenation can be a direct and facile approach for synthesizing aliphatic germanes directly from the aromatic germanes that can link the chemical space between 2D aromatic rings with the 3D aliphatic saturated rings. − However, a major barrier to achieve this goal is the tolerance of sensitive functional groups, which are directly connected to the aromatic rings including the germane group itself. For example, organogermane can be unstable in the presence of electrophiles as well as nucleophiles .…”

Section: Introductionmentioning

confidence: 99%

cis-Selective Hydrogenation of Aryl Germanes: A Direct Approach to Access Saturated Carbo- and Heterocyclic Germanes

et al. 2023

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A catalytic approach of synthesizing the cis-selective saturated carbo-and heterocyclic germanium compounds (3D framework) is reported via the hydrogenation of readily accessible aromatic germanes (2D framework). Among the numerous catalysts tested, Nishimura's catalyst (Rh 2 O 3 /PtO 2 •H 2 O) exhibited the best hydrogenation reactivity with an isolated yield of up to 96%. A broad range of substrates including the synthesis of unprecedented saturated heterocyclic germanes was explored. This selective hydrogenation strategy could tolerate several functional groups such as −CF 3 , −OR, −F, −Bpin, and −SiR 3 groups. The synthesized products demonstrated the applications in coupling reactions including the newly developed strategy of aza-Giese-type addition reaction (C−N bond formation) from the saturated cyclic germane product. These versatile motifs can have a substantial value in organic synthesis and medicinal chemistry as they show orthogonal reactivity in coupling reactions while competing with other coupling partners such as boranes or silanes, acquiring a three-dimensional structure with high stability and robustness.

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“…Hydrogenation of organic compounds plays an important role in modern organic synthesis because it can serve as a powerful tool for the degradation of biomass, and the synthesis of medicines and fine chemicals. [1][2][3][4][5][6][7][8][9][10] Traditionally, hydrogen gas is used as a hydrogenation reagent in this kind of reaction. 11,12 However, the potential danger of hydrogen gas at highpressure would bring considerable trouble to practices in organic synthesis.…”

Section: Introductionmentioning

confidence: 99%